所謂奈米磁粒熱療，乃是利用直徑10~50 nm的氧化鐵(Fe3O4)顆粒，於外加交變磁場下將奈米磁粒加溫至42℃以上，以達到殺死癌細胞的目的。這種磁流體熱治療法(MFH, magnetic fluid hyperthermia)在生醫領域中扮演著“醫生的手”角色，正是目前醫界與工程研究單位努力研究的重點。在電路設計上，本研究改良了全/半橋DC-AC轉換電路，利用Is Spice4.0進行模擬並與實際測量的比對電路結果。我們也創新的自製差動型八字對輻射加溫線圈組，利用阻抗分析儀量測組抗特性建立不同元件的模型，並利用Ansoft Designer進行電路模型模擬與量測比對結果。在電路穩定的技術上，我們加入許多電磁干擾(EMI)防護技術，利用頻譜分析儀量測雜訊分量並適時的在系統內加入許多濾波電路與結構。在效率分析上，我們也分別針對系統、輻射線圈等做效率量測與探討，並找出加溫系統的最佳效率值，基於理論定性的探討出最佳加溫頻率。我們設計適當的磁流加溫輻射系統進行加溫試驗，將實驗數據加以定量分析，以新的觀點探討實驗效率。針對不同實驗樣本的熱吸收能力（SAR, specific absorption rate)與電源輸出功率做比對，找出系統針對不同樣本時的最佳加溫效率的操作點。基於系統的設計觀點，只要針對生物所能適用的不同實驗樣本與濃度，找到最佳的加溫效率點，我們就有信心在未來進行多項性的生物熱治療實驗。

Hyperthermia with magnetic fluid will act as “Doctor's Hand” in biomedical science. Medical Science and Engineering has been made efforts on this issue which can raise the temperatures over 42oC by synthetic iron oxides (Fe3O4). On the know-how of magnetic fluid heating system design, we have improved pseudo full bridge DC/AC converter. Besides, the simulation tool, “Is spiceTM “, is used for verifying our circuits. We have made a new radiation coil and built several models of the circuit by impedance analyzer. In addition, we used “Ansoft designer v.1.1” to verify the models. What make the system stable is that we used some of EMI (Electromagnetic Interference) proof techniques to reduce the noise and measure the noise weight by using spectrum analyzer. Consequently, we can stabilize our system. Refer to the estimations of the system efficiency, we can quantize and analysis the efficiency of circuit and radiation coil. Regarding the heating frequency optimization for 10 nm synthetic iron oxides, the magnetic fluid heating system (240 kHz) was designed by limited physics theories. According to experiment results, we got a new prospect for experiment efficiency. Compare Specific absorption rate (SAR) with the power source, we can find out where the optimum operation point is referring to system performance. As long we can find the optimum operation point with different samples, we are confident to make variety of hyperthermia experiments on biomedical field.

[1] A. Ito , K. Tanaka, “Complete Regression of Mouse Mammary Carcinoma with
a Size Greater than 15 mm by Frequent Repeated” , Journal of Bioscience
and Bioengineering, Vol. 96, No. 4 pp.364-369, 2003.
[2] W. Pinson, M. Sandler, “Newly Indentified Protein Linked To Cancer Cell
Survival” ,ScienceDaily Magazine ,Vanderbilt University Medical Center ,
Posted: March 18, 2002.
[3] G. Blander, N. Zalle, Y. Daniely, “DNA Damage-induced Translocation of
the Werner Helicase Is Regulated by Acetylation” ,Biological Chemistry,
Vol. 277, No. 52, pp.50934–50940, 2002.
[4] Halliday, Resnick, walker, “Fundamentals of Physics 6th”, Wiley 2001.
[5] 吳石順,“高科技之材料檢測” ,全華圖書,民國81年5月。
[6] D. L. Holligan, G.. T. Gillies and Dailey, “Magnetic guidance of
ferrofluidic nanoparticles in an in vitro model of intraocular retinal
repair” ,Nanotechnology 14 pp.661–666, 2003.
[7] S. Reddy, L. R. Moore, L. Sun, M. Zborowski and Chalmers, “Determination
of the magnetic susceptibility of labeled particles by video
imaging” ,Chemical Engineering Science, Vol. 51, Num 6, pp. 947-956(10),
Mar 1996.
[8] M. Zborowski , C. B. Fuh, R. Green , L. Sun and J. J. Chalmers,
“Analytical Magnetapheresis of Ferritin-Labeled Lymphocytes” , Analytical
Chemistry, Vol. 67, No. 20, pp.3702, Oct 15, 1995.
[9] V. S. Kalambur, B. S. Han, B. E. Hammer, “In vitro characterization of
movement heating and visualization of magnetic nanoparticles for
biomedical applications” ,Appl Phys Nanotechnology 16, pp.1221-1233, 2005.
[10] W. F. Brown, “Thermal Fluctuations of a Single-Domain Particle” ,
Physical Review ,Appl phys 34, Vol. 130, Num 5, pp.1319, Jun 1963.
[11] D. Weller and A. Moser, “Thermal Effect Limits in Ultrahigh Density
Magnetic Recording” ,IEEE Trans on Magn, Vol.35, No.6, pp.4423–4439,
Nov 1999.
[12] P. C. Fannin, S. W. Charles, C. M. Oireachtaigh, S. Odenbach,
“Investigation of possible hysteresis effects arising from frequency and
field dependent complex susceptibility measurements of magnetic fluids” ,
Journal of Magnetism and Magnetic Materials, Vol. 302, Issue 1, pp.1-6,
Dec 5 2003.
[13] M. Ma, “Size dependence of specific power absorption of Fe3O4
particles in AC magnetic field” ,Journal of Magnetism and Magnetic
Materials, Vol. 268, Num 1, pp.33–39, Jan 2004.
[14] D. H. Kim, “Temperature change of various ferrite particles with
alternating magnetic field for hyperthermic application” ,Elsevier
Journal of Magnetism and Magnetic Materials, Vol. 293 , pp.320–327, 2005.
[15] R.Kotiz, P. C. Fannia, J. Trahms, “Time domain study of Brownian and
N6el relaxation in ferrofluids” ,Magn. Mater, Vol.149, pp.42-46, 1995.
[16] Rudolf Hergt, “ Physical Limits of Hyperthermia Using Magnetite Fine
Particles” ,IEEE Transations on Magnetics, Vol. 34, No. 5, pp.3745-3754,
SEP 1998.
[17] M. G. Borage, “A Passive Auxiliary Circuit Achieves ZVS in Full-Bridge
Converter Over Entire Conversion Range” ,IEEE Power Electronics leter,
Vol. 3 No. 4, DEC 2005.
[18] C. S. Wang, J. P. Xu, Qun Zhang, “A Novel Zero-Current Technique for
High Power Full Bridge DC-DC Converter” , lEEE Transactions on Power
Electronics, Vol. 6, No. 3, pp.408-418, JUL 1991.
[19] M. K. Kazimierczuk, “Class D voltage switching MOSFET power
amplifier” ,IEE Electric Power Applications, Vol.138, No. 6, pp.285-296,
Nov 1991.
[20] S. Hamada, “Analysis and Design of a Saturable Reactor Assisted
Soft-S witching Full-Bridge dc-dc Converter” ,IEEE Transaction on Power
Electronics, Vol. 9, No. 3, pp.309-317, May 1994.
[21] 陳弼先,“無線透膚電能傳輸系統之研究” ,國立成功大學電機工程學系碩士
論文，民國八十七年。
[22] D. K. Cheng, ”Field and Wave Electromagnetics2/e” ,ISBN 957-98991-0-X.
[23] 謝沐田, ”高低頻變壓器設計” ,全華, pp.42-46、pp99-100, 84年7月。
[24] TI, “Current Doubler Rectifier Offers Ripple Current
Cancellation” ,Application Note SLUA323-SEP 2004.
[25] X. B. Ruan, J. G. Wang, “Calculation of Resonant Capacitor of the
Improved Current-Doubler-Rectifier ZVS PWM Full-Bridge Converter” ,IEEE
Trans on Indus elect, Vol. 51, NO. 2, pp.518-520, Apr 2004.
[26] F. Y. Shih, D. Y. Chen, Y. P. Wu, and Y. T. Chen, “A Procedure for
Designing EMI Filter for AC Line Applications” ,IEEE Trans. Power
Electronics, Vol. 11, No. 1, pp.170-181, Jan 1996.
[27] 陳明坤， ”磁性奈米粒子熱治療系統” ，95年國科會提案計畫報告。
[28] G.S. Smith, “Radiation Efficiency of Electrically Small Multiturn Loop
Antennas” ,IEEE Transactions on Antennas and Propagation, Vol. 20, No.
5, pp.656-657, SEP 1972.
[29] S. S. Hamada, “Analysis and Design of a Saturable Reactor Assisted
Soft-S witching Full-Bridge dc-dc Converter” ,IEEE Transactions on Power
Electronics, Vol. 9, No. 3, pp.309-317, MAY 1994.
[30] M. Xu, Y. C. Ren, J. G. Zhou, and F. C. Lee, Fellow, “1-MHz Self-Driven
ZVS Full-Bridge Converter for 48-V Power Pod and DC/DC Brick” ,IEEE
Transactions on Power Electronics, Vol. 20, No. 5, pp.997-1006, SEP 2005.
[31] G. B. Joung, “An Energy Transmission System for an Artificial Heart
Using Leakage Inductance Compensation of Transcutaneous Transformer” ,
Power Electronics, IEEE Transactions on, Vol. 13, No. 6, pp.1013-1022,
NOV 1998.
[32] B. R. Lin, K. Huang and D. Wang, “Analysis and implementation of full-
bridge converter with current doubler rectifier” , IEE Proc. Electr.
Power Appl., Vol. 152, No. 5, SEP 2005.
[33] Tim Willams, “EMC for Product Designers 3rd” ,ISBN 957-21-4900-8.
[34] L. Neel, “ Thermoremanent Magnetization of Fine Powders” ,Phys. Rev,
Vol. 25, No.1, pp.293-295, JAN 1953.
[35] L. Neel, “Some New Results on Antiferromagnetism and Ferromagnetism” ,
Phys. Rev, Vol. 25, No. 1, pp.58-63, JAN 1953.
[37]林慶仁, 宋自恒, “傳導性 EMI量測系統的架構及原理”, 新電子科技雜誌第186期,
2001年9月.
[38]宋自恒, 林慶仁, ”切換式電源供應器的EMI濾波器設計方法” , 新電子科技雜誌第
187期, 2001年10月。
[39]S. D. Sarma, “Spintronics”, American Scientist, Vol 89, pp.516-523, Nov
2001.
[40]王子瑜, 曹恒光, “布朗運動、朗之萬方程式、與布朗動力學”, 物理雙月刊, 二十
七卷三期, 2005年6月。