癌症治療一直是人類非常關注的議題，但許多治療方式都會帶來嚴重的後遺症，其中電磁熱治療是較無副作用的治療方法。將交流電通過線圈產生交變磁場，使具感磁性的金屬針具內部產生渦電流而加熱，藉此殺死腫瘤細胞。金屬針溫的加熱效果和磁場感應及插入角度有密切的關係，金屬針如未垂直線圈平面，會導致金屬針無法有效感應磁場產生焦耳熱，使金屬針升溫效果明顯下降。本論文使用田口法結合有限元素法模擬，決定高針溫響應線圈(High T Coil)參數，並藉由ANFIS數學模型搭配基因演算法找出入針角度變化下低溫差響應線圈參數(Low DeltaT Coil)。本論文提出一簡易且低成本的線圈優化設計方法，來提高金屬針溫度，並提出一線圈優化設計流程，在入針角度改變時，使金屬針溫度下降幅度較為緩和。本文並以有限元素法軟體進行電磁與熱傳導複合物理量模擬分析，並進行組織加熱實驗。最後，實驗測試高針溫響應線圈在不同深度1、3、5公分下之加熱結果，以及，入針角度變化下低溫差響應線圈在金屬針變化45度角時，金屬針溫度落差之加熱結果，並對結果分析與討論。

Electromagnetic thermotherapy is currently a cancer treatment with fewer side effects. By passing high-frequency currents through an induction coil to generate an alternating magnetic field, a magnetic metal needle is rapidly heated by the internal eddy currents to kill tumor cells. When the metal needle is perpendicular to the coil plane, the needle temperature is closely related to the magnetic field strength. Nevertheless, the metal needle not perpendicular to coil plane would not effectively induce the magnetic field to generate Joule heat that the metal needle temperature would obviously reduce. Taguchi Method is combined with FEM in this study to decide the high needle temperature response coil (High T Coil). ANFIS model is used with Genetic Algorithm to find out the low needle temperature variation coil (Low DeltaT Coil), under changing needle insertion angles, for the application to the electromagnetic thermotherapy system. An optimization design procedure is proposed in this study to enhance the metal needle temperature. Besides, a coil design process is proposed to release the decreasing metal needle temperature, under changing needle insertion angles. Finally, the coil is actual winded to test the metal needle heating effect under High T Coil at different coil depths of 1, 3, and 5 cm. Besides, the heating results of the metal temperature variation using Low DeltaT Coil at the 45 degree is analyzed and discussed.

[1] G. Ma, and G. Jiang, "Review of Tumor Hyperthermia Technique in Biomedical Engineering Frontier," 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI), IEEE, pp. 1357-1359, 2010.
[2] A. Jordan, P. Wust, H. Fahking, W. John, A. Hinz, and R. Felix, "Inductive Heating of Ferromagnetic Particles and Magnetic Fluids : Physical Evaluation of their Potential for Hyperthermia," Int. J. Hyperthermia, vol. 25, pp. 499-511, 2009.
[3] X. Z. Lin, R. Zuchini, H. W. Tsai, C. Y. Chen, C. H. Huang, S. C. Huang, et al., "Electromagnetic Thermotherapy Using Fine Needles for Hepatoma Treatment," Eur. J Surg. Oncology, vol. 37, pp. 604-610, 2011.
[4] I. Kimura and T. Katsuki, "VLF induction heating for clinical hyperthermia," IEEE transactions on magnetics, vol. 22, pp. 1897-1900, 1986.
[5] J. R. Oleson, "A review of magnetic induction methods for hyperthermia treatment of cancer," IEEE transactions on biomedical engineering, pp. 91-97, 1984.
[6] 楊易儒，「應用於磁場感應熱療的線圈系統設計」，大同大學電機工程學系碩士學位論文，2009。
[7] C. F. Huang, X. Z. Lin, and Y. R. Yang, "Application of magnetic circuit and multiple-coils array in induction heating for improving localized hyperthermia," in International Conference on Bioinformatics and Biomedicine, 2009.
[8] C. F. Huang, H. Y. Chao, H. H. Chang, and X. Z. Lin, "A magnetic induction heating system with multi-cascaded coils and adjustable magnetic circuit for hyperthermia," Electromagnetic biology and medicine, vol. 35, pp. 59-64, 2016.
[9] 洪家銘，「深度磁場感應加熱線圈」，國立成功大學電機工程學系碩士論文，2014。
[10] V. Sharma, A. Patel, A. Sharma, and K. Mittal, "Design and analysis of magnetic coil for relativistic magnetron," in Discharges and Electrical Insulation in Vacuum (ISDEIV), 2014 International Symposium on, 2014, pp. 181-183.
[11] C. C. Chen, C. C. Tai, S. J. Huang, Y. H. Chen, and C. H. Lin, "Thermotherapy induction heating apparatus with new magnetic-wrapped coil design," IEEE Transactions on Industrial Electronics, vol. 61, pp. 2592-2600, 2014.
[12] D. E. Bordelon, R. C. Goldstein, V. S Nemkov, A Kumar, J. K. Jackowski, T. L. DeWeese, and R. Inkov. "Modified Solenoid Coil That Efficiently Produces High Amplitude AC Magnetic Fields with Enhanced Uniformity for Biomedical Applications," IEEE Trans Magnetics, vol. 48, no. 1, 2012.
[13] S. C. Huang, J. W. Kang, H. W. Tsai, Y. S. Shan, X. Z. Lin, and G. B. Lee, "Electromagnetic Thermotherapy for Deep Organ Ablation by Using a Needle Array Under a Synchronized-Coil System," IEEE Transactions on Biomedical Engineering, vol. 61, pp. 2733-2739, 2014.
[14] 黃聖傑，「電磁熱療系統應用於腫瘤微創治療及臟器切除療程」，國立清華大學動力機械工程學系學位論文，2015。
[15] 武建安，吳祖河，王亨，李利亞，唐勁天，「基于有限元仿真的磁感應腫瘤治療設備線圈優化設計」，清華大學學報(自然科學版)，第56卷，頁406-410，2016年。
[16] 劉崇顯，「止血栓整合至電磁熱療系統於外科肝臟破裂治療手術之應用」，國立清華大學動力機械工程學系學位論文，2014。
[17] C. H. Liu, S. C. Huang, Y. J. Chao, X. Z. Lin, and G. B. Lee, "Hemostasis Plug for an Electromagnetic Thermotherapy and Its Application for Liver Laceration," Annals of biomedical engineering, vol. 44, pp. 1310-1320, 2016.
[18] C. C. Tai, C. C. Chen, C. C. Kuo, F. W. Lin, C. J. Chang, Y. H. Chen, et al., "Deep-magnetic-field generator using flexible laminated copper for thermotherapy applications," IEEE Transactions on Magnetics, vol. 50, pp. 1-4, 2014.
[19] 郭仲欽，「可繞式磁感應加熱線圈應用於金屬針加熱之溫度模擬與組織燒灼面積分析」，國立成功大學電機工程學系碩士論文，2014。
[20] V. Nemkov, R. Goldstein, R. Ruffini, J. Jackowski, T. DeWeese, and R. Ivkov, "Design study of induction coil for generating magnetic field for cancer hyperthermia research," in Proc. Int. Symp. on Heating by EM Sources, Padua, 2010.
[21] M. D. Nieskoski and B. S. Trembly, "Comparison of a single optimized coil and a helmholtz pair for magnetic nanoparticle hyperthermia," IEEE Transactions on Biomedical Engineering, vol. 61, pp. 1642-1650, 2014.
[22] 蕭正昌，「應用於腫瘤熱療之奈米磁粒加熱系統研製」，國立成功大學電機工程學系碩士論文，2006。
[23] 陳明坤、戴政祺，「半橋式串聯共振變流器於磁性奈米粒子熱療系統之應用」，生物醫學工程科技研討會暨國科會醫學工程學門成果發表會，2006。
[24] 陳建璋，「半橋串聯共振式磁奈米粒熱療加熱系統研製」，國立成功大學電機工程學系碩士論文，2007。
[25] 許元瑞，「結合類神經網路學習機制與溫度參考曲線模型之模糊溫度控制器於電磁熱療系統之應用」，國立成功大學電機工程學系碩士論文，2016。
[26] 傅超群，「電磁感應加熱變動性負載系統之模糊溫度控制器設計」，國立成功大學電機工程學系碩士論文，2017。
[27] 陳俊成，「應用於奈米磁粒之半橋串聯諧振式雙頻耦合熱療加熱系統」，國立成功大學電機工程學系碩士論文，2008。
[28] 陳仰豪，「多頻段感應加熱系統設計與大電流感測應用」，國立成功大學電機工程學系碩士論文，2012。
[29] 孔維彬，「以有限元素分析法作感應加熱線圈分析」，國立成功大學電機工程學系碩士論文，2008。
[30] 林子翔，「奈米粒熱療加熱系統之中低頻磁場聚焦探頭設計」，國立成功大學電機工程學系碩士論文，2009。
[31] 曾名弘，「奈米粒熱療加熱系統之模擬與探頭模型分析」，國立成功大學電機工程學系碩士論文，2011。
[32] 林方偉，「應用於電磁熱療之新型可撓式線圈設計」，國立成功大學電機工程學系碩士論文，2014。
[33] P. Urbanek, A. Skorek, and M. B. Zaremba, "Magnetic flux and temperature analysis in induction heated steel cylinder," IEEE transactions on magnetics, vol. 30, pp. 3328-3330, 1994.
[34] COMSOL MULTIPHYSICS, User’s Guide, Version 5.2 a.
[35] 李輝煌，「田口方法-品質設計原理與實務」，新北市：高立圖書有限公司，2013。
[36] 藍毓傑，「垂直式滾珠螺桿之螺帽分析與設計」，國立成功大學工程科學系碩士論文，2014。
[37] 鄭凱文，「應用類神經網路、田口方法、主成份分析法與順序偏好法於多重品質特性製程改善之研究」，國立成功大學工業與資訊管理學系碩士論文，2012。
[38] 張斐章、張麗秋，「類神經網路導論原理與應用」，滄海圖書，2015。
[39] 魏士翔，「ANFIS應用於混凝土抗壓強度預測模式」，國立高雄應用科技大學土木工程學系碩士論文，2009。
[40] 蘇人煇，「利用不同類神經網路預測輕質混凝土強度最佳化之研究」，私立逢甲大學土木工程學系碩士論文，2010。
[41] 周鵬程，「遺傳演算法原理與應用-活用Matlab」，全華科技圖書股份有限公司，2005。
[42] 張裕長，「應用類神經與遺傳演算法於雙螺絲骨釘中遲滯螺絲之多目標問題最佳化設計」，國立臺灣科技大學機械工程學系碩士論文，2009。
[43] 顏靜良，「結合類神經田口法與基因演算法為基礎於冷軋板形製程參數最佳化之設計」，國立成功大學工業設計學系碩士論文，2011。