近年來，水環境易於受到藻華發生時大量藍綠菌所產生的代謝物汙染。藍綠菌產 生的代謝物可能會經由人們飲用或水上娛樂對人體健康產生危害，其中微囊藻毒 (Microcystin)為最著名的藍綠菌毒素之一。然而，從研究報告中得知，與藍綠菌 相關的毒素不僅是微囊藻毒，並建議納入其他生物性之代謝物，尤其對於藍綠菌胜 肽的研究也需要多加關注。藍綠菌除了產生微囊藻毒之外，也能產生 anabaenopeptins 和 microginins 此兩類代謝物，研究結果顯示 anabaenopeptin-B(AP- B)比起微囊藻毒對於水蚤有更強的毒性，而 microginins 會對人類細胞造成遺傳性 毒害，顯示對於藍綠菌胜肽需要有進一步的研究。
本研究首先針對台灣不同水庫及淨水廠中六種藍綠菌胜肽分布進行調查研究， 其中蚌蛤毒素及兩種藍綠菌胜肽 AP-B 和 Microginin 527(MG572)在六座水庫的原水 中出現頻度為 100%，並且在每座水庫中均可同時檢驗出四種以上的藍綠菌胜肽。除 此之外，在傳統淨水程序中的沉澱和過濾單元並無法有效的將藍綠菌胜肽完全去除， 而生物處理單元或逆滲透處理程序可以提升藍綠菌生態去除效率。
本研究亦對此兩種高機率出現的藍綠菌胜肽 (AP-B 和 MG527)進一步研究，以瞭 解兩種 cyanopeptides 對於高錳酸鹽和氯的氧化反應速率。實驗結果顯示，AP-B 與高 錳酸鉀作用，反應速率常數為 31.08–97.5 M-1s-1，MG527 的反應速率常數則為 167.59–284.93 M-1s-1。以氯氧化時，AP-B 的反應速率常數為 76.42 – 276.05 M-1s-1， MG527 則為 182.79 – 370.43 M-1s-1。 與 AP-B 環狀肽結構相比，MG527 的線性結構可能為反應速率常數較大的原因。 而高錳酸鉀在天然水系統中鐵離子所產生的催化 效應，可能導致比在去離子水中的反應速率更快。

Our water system is prone to the harm of the metabolites produced by the cyanobacteria. These metabolites can be consumed by humans through drinking water or be exposed through recreational water uses in areas where cyanobacterial blooms occur. One of the most well-known cyanotoxin that receives most of the attention is microcystin. However, studies have shown the observed toxic effects associated with cyanobacteria cannot be simply attributed to microcystins, suggesting that other bioactive metabolites should also be considered. Thus, occurrence of cyanopeptides other than microcystins around the world should have been studied more. Other metabolites that are frequently appear aside from microcystins are anabaenopeptins and microginins. Studies showed that the toxic effects on the behavior of Daphnia magna with anabaenopeptin-B (AP-B) and microginin genotoxicity towards human cell line is present, which indicates further attention toward this cyanopeptides is important.
In this study, water samples from different reservoirs in Taiwan were investigated for its cyanopeptides contents. Aside from that, further examination for two kinds of cyanopeptides (Anabaenopeptin-B and Microginin 527) were also investigated for understanding their reaction rates with permanganate and chlorine.
The experimental results show that in those water samples, the cyanopeptides occurrence is apparent. Dominating species is microcystin, however the occurrence frequency of both Anabaenopeptin-B and Microginin 527 are visible in all of the water samples. Aside from that, it was also found that sedimentation and filtration processes are not effective enough in terms of removing cyanotoxins in the clear water while biological treatment or reverse osmosis membrane were able to effective remove most of the studied cyanoptoxins.
From the oxidation experiments conducted, the results for rate constants of oxidation by permanganate for AP-B ranged from 31.08 to 97.5 M-1s-1 and for MG527 ranged from 167.59 to 284.93 M-1s-1. The rate constants of oxidation by chlorine for AP-B were 76.42 – 276.05 M-1s-1 and for Microginin 527 were 182.79 – 370.43 M-1s-1. Greater rate constant of Microginin 527 was possibly caused by the linear structure compared to Anabaenopeptin-B cyclic peptide structure. Faster reaction rate phenomenon in the raw water system compared to the DI water was possibly due to the catalysis process by iron ion in the natural water system, which may enhanced the reaction. More studies are suggested to be conducted for better understanding the occurrence and treatment of cyanopeptides.

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