奈米磁粒加熱系統主要是利用奈米級尺寸的氧化鐵(Fe3O4)顆粒，施加一中低頻交變磁場，使奈米磁粒產熱昇溫至42°C以上，將奈米磁粒引入腫瘤部位進行加熱，達到迫使腫瘤細胞衰亡的目的。本研究所採用的電路系統主要依據本實驗室設計的半橋加熱系統與市面上高週波加熱器，對加熱探頭部位進行改良，設計出具有較佳磁場聚焦效果的線圈銅管模型，藉以提高奈米磁粒加熱效率，並針對該模型使用有限積分法套裝軟體進行數值分析模擬。為了驗證設計的探頭在實作上是否與模擬的數值吻合，使用電磁感應法量測探頭幅射出的磁場，以此法所量測出來的數值與模擬數值相互驗證。依模擬結論提出兩種不同型態的加熱探頭新架構，未來將應用於奈米磁粒加熱系統上。

The notion of magnetic nanoparticle heating system is to inject nano-sized ferric oxide (Fe3O4) particles into the tumor, the particles are then heated up to 42°C and above, using a medium- and low-frequency alternating magnetic field, aiming to destroy the tumor cells. The major task of this study is to improve the efficiency of magnetic nanoparticle heating system via reform of the applicator. The half-bridge heating system developed in our laboratory is used in combination with high-frequency heating apparatus, which is available in the market, to propose models consist of brass tubes and coils to bring better magnetic focusing performance. These models are numerical analyzed and simulated with finite integration theory software. The electromagnetic induction method was applied to measure the magnetic field which the applicator radiates. This is to authenticate the simulated data obtained from numerical analysis software. Two different models were designed according to the conclusions from the simulations, and will be applied in magnetic nanoparticle heating system in the future.

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