在全世界約五千萬個癲癇病人中，仍有近三分之一的病人，在服用兩種以上抗癲癇藥物的情況下，仍無法達到有效控制發作，屬於難治型癲癇病患。目前對於難治型癲癇的治療，醫生會採取切除部分腦組織的方式來控制病情，但此一方式將對病人腦部造成永久性的傷害。若病灶位於語言、運動等重要功能區域，便無法以切除手術治療該病患之癲癇症。由於腦部切除手術將對腦部造成不可回復之傷害，在不切除腦部組織前提之下，如何控制難治型癲癇成為近年來重要的研究課題，深顱電刺激術(deep brain stimulation，DBS)即是深具潛力的治療方式(如圖1.1所示)，並已被美國食品與藥品管理局(FDA)納入難治性癲癇的輔助治療手段。
近年來，許多團隊逐漸投入植入式電刺激器的開發，但將刺激電極植入正確腦區並確認電極運作正常，更是讓深顱電刺激發揮功能的重要關鍵。但對於開發電極手術植入所需的輔助系統，投入的研究相對稀少，即使有優良的顱內電刺激系統也未必能發揮正常功效。就我們過去長期的研究發現，對視丘下核(subthalamic nucleus, STN)下背側的zona incerta (ZI)區進行高頻率電刺激能有效中斷癲癇的發作[1]，並開發一套閉迴路電刺激器來有效控制癲癇的病情[2][3][4]。但若手術中電極不安置在正確位置，或手術後選擇的刺激電極異常，則無法發揮功能。因此我們將開發一套深顱電刺激器植入手術中電極埋置輔助系統用以確保將電極放置於ZI位置，以及一套手術復原後電刺激通道選擇系統，確保刺激電極正常運作，發揮癲癇抑制功效。預期本系統將來可為DBS的臨床應用與動物實驗，帶來更多的成效與助益，推進相關技術的開發。

Epilepsy is one of the most common neurological disorders and a considerable portion of drug resisted epileptic patients cannot be well treated by available therapies nowadays. Deep brain stimulation (DBS) has been investigated for the treatment of epilepsy. Recently, an increase for the development of seizures has been reported in different animal models but the consequences of delivering stimulation to chronic epileptic animals remain unaddressed extensively.
In this study, we have successfully integrated a DBS system including: surgery, electrode implantation, stimulation parameters, EEG monitoring system and a portable stimulation channel switch allowed to manually select each pair of channels to find the best stimulation channel pair for future use. It has several aspects of advantages, which improves flexibility, mobility and easy-to-use of users. In the future, our system can also be extended for a variety of biomedical surgeries or experiments about deep brain stimulation. Currently, we had implemented this system on experiments including deep brain electrode implant in Zona Incerta on Long-Evans Rats, finding of best stimulation channel pair to inhibit Epilepsy on Chronic Epileptic Rats.

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