所謂奈米磁粒子電磁熱療，乃是利用奈米級的氧化鐵顆粒做為載體，當其包覆脂質或藥物後，因為奈米磁粒本身的材料特性將會對特定癌細胞產生依附作用，再以外加的電磁加熱系統所輻射出的交變磁場，使奈米磁粒吸收磁能後轉成功率熱損而提升溫度，此高溫能抑制癌細胞的成長並且使附載在奈米磁粒上的藥物成功地發揮其療效，達到治療及殺死癌細胞的目的。由於任何濃度的奈米磁粒在固定的交變磁場作用下最後都將趨於熱飽和的狀態，即加熱溫度達某一溫度值之後就不易繼續升溫的特性，所以希望能藉由外加頻率擾動訊號的方式將熱飽和溫度向上提升。本研究設計了一套微處理機控制的可變頻率弦波擾動訊號產生系統，在系統的設計上運用了半橋串聯諧振式電路為主要之觀念構成系統主體，在已知功率損耗和頻率及磁場的關係下，整體實驗將架構在固定的交變磁場情況下進行，觀察奈米磁粒受到固定的交變磁場作用下分別載入不同的頻率擾動訊號時的升溫情形。實驗結果顯示當載入擾動訊號時奈米磁粒熱飽和溫度可以向上提升1.2~2.2 ℃。最後並探討不同濃度的奈米磁粒於不同操作頻率下的升溫效果。

The main idea of magnetic nanoparticles electromagnetic thermotherapy is to use ferric oxide nanoparticles as carriers, which are packaged with lipid or drug to attach to specific cancer cells. The temperature of magnetic particles is risen by absorbing magnetic energy from external AC magnetic fields. The heat can make the good curative effects to cancer cells from drugs-bearing magnetic particles. And the high temperature can inhibit the growing of cancer cells. In order to achieve the goal of killing cancer cells using the AC magnetic field, we designed a heating system to generate magnetic field. The heating system adopts the half-bridge series-resonant circuit as the core scheme of the heating system. Since any density of Fe3O4 will finally reach hot saturation condition in the fixed magnetic field, therefore affiliation is created to disturb the signal for temperature upward promotion. The adjustable frequency of the sine wave disturbance system is controlled via a microprocessor. Since the relation between power loss, frequency and magnetic field is known, all the experiments are carried out under fixed alternating magnetic field situation. Under fixed alternating magnetic field the effect of perturbation signal with different frequency on magnetic nanoparticles is observed. The experimental results show that the perturbation signal further promote the temperature of magnetic nanoparticles by 1.2 ~ 2.2 ℃. Finally, we will discuss the heating effect of different density magnetic nanoparticles under different operating frequency.

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