近年來，磁奈米粒腫瘤熱療在醫學上已成為很重要的技術，由於磁奈米粒在交變磁場的作用下，在腫瘤上會產生各種物理的加熱機制，藉此達到熱療效果。此外，磁奈米的顆粒大小、磁場大小與頻率都會影響磁奈米粒的加熱效果，目前研究上尚未有具體的最佳熱療機制。本研究採用半橋串聯諧振電路與可控制磁場頻率的設計為系統主體，利用半橋諧振電路在感應加熱的探頭上產生交變磁場，對磁奈米粒進行加熱實驗。實驗結果顯示，磁奈米可在室溫下最高升溫10.1℃。此外，在本研究也探討磁奈米在不同頻率與不同濃度下之加熱特性，這些結果可作為磁奈米粒腫瘤熱療臨床應用的參考。

The hyperthermia for tumor by magnetic nanoparticle (MNP) has been an essential medical treatment technique recently. MNP causes heat of physical mechanism on the tumor to make hyperthermia under alternative electromagnetic field. Both the size of nanoparticle and the strength and frequency of magnetic field have influence to the heating effect of MNP. However, there is no standard hyperthermia mechanism is proposed up to present. This study adopts the half-bridge series-resonant type circuit and controllable frequency as the core scheme of the heating system. The topology generates the alternative electromagnetic field on induction heating applicator and conducts the heating experiments. The experiment results show that the MNP produces thermal loss and its maximum temperature increases by 10.1℃ under room temperature. Furthermore, this study explores the heating characteristics of MNP with various frequencies and nanoparticle concentration. The results could be used as a basis for clinical application of the MNP hyperthermia cancer therapy.

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