在現代社會，國人患有慢性病比例越來越高，簡易且定時的檢體檢測需求量大增。生物晶片的發展是希望將化學分析的儀器微小化並整合在晶片上，進而帶來低成本、可攜性高、即時化等好處。使用電化學量測中常見的電化學阻抗頻譜分析法 (Electrochemical Impedance Spectroscopy ,EIS) 時需要兩組相同振幅及相位的弦波訊號。在本論文中將介紹一個具寬廣可調頻率範圍的弦波合成器。此弦波合成器具有寬廣且線性調整的頻率範圍且在訊號品質及電路面積皆優於一般市售弦波產生器。
此晶片使用使用台灣積體電路公司 (TSMC) 0.35 μm 2P4M 3.3 V混合訊號製程，以24 S/B封裝，尺寸為1.2×1.2 mm2。此弦波產生器可輸出頻率範圍為10 Hz到10 kHz，訊號品質可達到總諧波失真 (THD) 小於 -67 dB。

Nowadays, there is increasing proportion of people having chronic diseases. A method, which can be easily and frequently used to monitor chronic diseases, is needed. Therefore, biochips have drawn more and more attentions, because it can reduce the size of the electrochemical analyzing instrumentation and integrate the whole instrumentation into a chip. Electrochemical Impedance Spectroscopy (EIS) is one of the most popular electrochemistry detection methods, and this method needs to inject two identical sine waves. In this work, a wide-range programmable-frequency sinusoidal frequency synthesizer for EIS measurement system is proposed.
This chip was fabricated by using Taiwan Semiconductor Manufacturing Company (TSMC) 0.35μm 2P4M 3.3 V mixed-signal polycide process. The total size of this chip is 1.2×1.2 mm2. This sine wave synthesizer can produce a wide frequency range of sine waves ranging from 10 Hz to 10 kHz, and the total harmonic distortion is less than -67 dB.

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