現代人的疲勞程度是目前受到大家極為關注的議題，而針對長時間的慣性動作(如辦公室久坐、電腦文明病)所引發的疲勞仍不容易監測。
一般量測的末梢血流變化、血乳酸等均屬於全身指標，反映的是機體的整體代謝情況，而本論文中所量測的肌氧含量則可以反映局部肌肉的氧平衡情況與疲勞變化，且由相關性探討也可看出肌氧含量是一個可用來反應人體代謝以及局部代謝的指標。

目前對肌肉疲勞的研究仍大多為肌電圖量測，而將肌肉中血氧含量用於肌肉疲勞的研究至今仍不多見，本論文設計反射式血氧飽和度量測系統希望能較為直觀的反應疲勞前後的差異，探討其可行性及臨床應用價值。系統採用等吸收點（isosbestic point , 波長805nm）附近的紅光（波長660nm）及紅外光（波長940nm）測定血氧的方式來取得局部疲勞所產生的肌氧變化，先確定其相關性進而研究較長時間引發的微量疲勞肌氧變化結果。

The tiredness degree is a modern topic which everybody paid much attention to. However, the fatigue of human’s inertia movement for a long time is still not easy to monitor. The study of blood oxygen saturation examined can reflect oxygen relative to oxygen balance of some muscle, and tiredness change, and the relations explains that it is a useful indicator for muscular fatigue and metabolism. Till now, most studies on muscular fatigue are still based on EMG, and the related researches by using blood oxygen saturation are still few. In this thesis, we designed a blood oxygen saturation system (oximeter) to compare the variation of the blood oxygen saturation before and after being tired.

The system adopts red light (wavelength 660nm) and infrared light (wavelength 940nm) neighboring the isosbestic point to measure blood oxygen saturation changes and confirm their correlation, then study the long-term variation of oxygen in a tired muscle.

1.Baker SJ,Tremper KK，Anesthesiology，86(1) ，1997
2.Belardinelli R,Barstow TJ,Porszasz J and Wasserman K， “Change in skeletal muscle oxygenation during incremental exercise measured with near infrared spectroscopy”．Eur J Appl Physiol，70：487—492，1995
3.Chance B,Nioka A,Kent T,McCully K,Fountain M,Greenfeld R and Holton G，“Time resolved spectroscopy of hemlglobin and myoglobin in resting and ischemic muscle [J].”，Anal biochem，174：698-707，1988
4.Tamaki T,Uchiyama S,Tamura T,et a1，“Changes in muscle oxygenation during weight-lifting exercise”，Eur J Appl Physiol，80：1345—50，l994
5.Miura H,Araki H,Matoba H,et a1，“Relationship Among Oxygenation, Myoelectric Activity, and Lactic Acid Accumulation in Vastus Lateralis Muscle During Exercise With Constant Work Rate”，Int J Sports Med，2000
6.Jobsis FF，“Non-invasive infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters”，Science，198：1264—1267，1977
7.Chance B,Dait MT,Zhang C,et a1，“Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers[J]”.Am.J.Physiol，262(cell Physiol.31)，C766-775，1992
8.Chance B, Cope M, Gratton E,et al，“Phase measurement of light absorption and scatter in human tissue[J]”，Review of scientificinstruments，69（10）：3457-3481，1998
9.http://www.medis-de.com/en/ppg.html
10.Webster JG, “Design of Pulse Oximeters”,IOP 1997
11.De Kock JP,Tarassenko L,Glynn CJ and Hill AR，“Reflectance pulse oximetry measurements from the retinal fundus”，IEEE Trans.Biomed.Eng. 40 817–23，1993
12.Mayle J，“Pulse Oximetry： Principles and Practice Series”，BMJ Publishing Group, London，1994
13.Nitzan M,Babchenko A,Khanokh B,Landau D，“The variability of the photoplethysmographic signal—a potential method for the evaluation of the autonomic nervous system”，Physiol. Meas.19，93–102. Printed in the UK，1998
14.Mendelson Y and Ochs BD，“Noninvasive Pulse Oximetry Utilizing Skin Reflectance Photoplethysmography”，IEEE Trans Biomed Eng. Oct;35(10):798-805.，1988
15.王強，王躍華“反射式紅外光譜組織血氧計感測器設計”，中國醫療器械雜誌, 1999
16.Nitzan M,Babchenko A,Shemesh D,Alberton D,“Influence
of thoracic sympathectomy on cardiac induced oscillations in tissue blood volume”，Medical & Biological Engineering & Computing，vol.39, 579-583，2001
17.徐國棟，李 南，駱清銘，葛新發，“肌氧含量的無損檢測及其與血乳酸濃度的關係”，武漢體育學院學報，Vo1.36，2002
18.鄧樹勛．運動生理學[M]，高等教育出版社，北京，1999
19.Askar T,Audia S,James J,Christophel T，“Redesign of a Pulse Oximeter”，April 13, 2004
20.Chance B,Mancini DM,Bolinger L,Li H,Kendrick K and Wilson JR，“Validation of near-infrared spectroscopy in humans”，J Appl Physiol 77: 2740-2747，1994
21.Chance B,Hamaoka TC,Albani C ,et a1，“A new method for the evaluation of muscle aerobic capacity in relation to physical activity measured by near infrared spectroscopy”，Intcrgration of Mcdical and Sports Science[J]， Med Sports Sci.，37：421—429，1992
22.Kyriacou PA，“Pulse oximetry in the oesophagus”，Physiol. Meas.27，R1–R35，2006
23.Lambert MA and Crinnion J，“The role of pulse oximetry in the accident and emergency department Arch. Emerg”，Med. 6 211–5，1989
24.Millasseau SC,Kelly RP,Ritter JM,Chowienczyk PJ，“ Determination of age-related increases in large artery stiffness by digital pulse contour analysis”，Clinical Science，2002
25.Romer LM,Haverkamp HC,Lovering AT,Pegelow DF, and Dempsey JA，“Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans”，Am J Physiol Regul Integr Comp Physiol 290: R365–R375，2006
26.Tremper K,Barker S，“Pulse Oximetry”，Anesthesiology, 70:98-108，1989
27.Tan X ,Chen Y,Deng Q，“Study on measuring method of pulse oxygen saturation in clinical monitor[J]，Chinese Journal of Medical Instrumentation，1999
28.Wendelken SM,McGrath SP,Akay M,Blike GT，“Using a forehead reflectance pulse oximeter to detect changes in sympathetic tone”，Engineering in Medicine and Biology Society，2004
29.Wukitsch MW, Petterson MT, Tobler DR, Pologe JA.，“ Pulse oximetry:analysis of theory, technology, and practice”，J Clin Monit，4:290-301，1988
30.Zhiqing Z，“Detection of optical sensors SpO2[J]”，Sensor World，5(2)：19—23(in Chinese) ，1999
31.丁海曙，王 峰，“紅外反射式組織含氧量無損檢測傳感技術研究[J]”，光電子•激光，(10)：123—126，1999
32.丁海曙，蘇暢，馮煒權，“人體運動氧代謝的即時無創測定[J]”，航太醫學與醫學工程，11(2)，1998
33.丁海曙，王榮輝，劉桂華，張一民，“不同強度運動肌氧含量變化特點”，北京體育大學學報第24卷第3期，2001
34.王士逢，“末梢血流與臉部肌電圖量測與焦慮狀態評估系統設計”，國立成功大學電機工程學系，2004
35.李秀榮，王景貴，張 立，“運動中肌肉氧含量下降與肌肉疲勞的關係”，武漢體育學院學報，VOl38 NO.2，Mar，2004
36.李秀榮，陸世添，“肌肉疲勞時肌氧與EMG參數的變化及其內在聯繫”，玉林師範學院學報(自然科學) Vo1.27，No3，2006
37.李景文，龍 村，張保洲，朗亞軍，黃 兵，“反射式血氧飽和度監測儀的設計與應用”，BME＆Clin Med，Vo1.7，No.1，2003
38.林育德，“心率、PPG和非侵入脈搏波信號之相關性研究”，逢甲大學自動控制工程學系碩士論文，2005
39.張志清，“光學傳感血氧飽和度的檢測[J]”，感測器世界，5(2)：19—23，1999
40.張海甯，李 岩，張翔，謝則平，瞿安連，“數位式無線肌血氧監測儀的研製”，生物醫學工程與臨床，第l0卷第2期，2006
41.曾小青，李旭光，熊政剛，李曉春，“一種具有高信噪比的脈搏波光電感測器的研製”，中國現代醫學雜誌， No.15，2003
42.馮奇，“基於MSP430超低功耗處理器的監護儀脈搏血氧模組”，电子科技大学，中國儀器儀表，第3期，2006
43.陳亞明，譚小丹，鄧清愷，“監護用脈搏式血氧飽和度測試方法的研究[J]”，中國醫療器件雜誌，33(3)：139—141，1999
44.陳敬修，“利用非侵入式Plethysmography信號評估手術病患舒張壓變化趨勢之研究”，中山大學機械與機電工程系碩士論文，2004
45.詹皓羽，“光體積變化描記圖之心血管功能診斷應用”，中原大學電機工程學系碩士論文，2004
46.Joseph J.Carr/江昭皚等譯著，“感測電路”，高立，1997
47.王唯工，“氣的樂章”，大塊文化，台北市，2002
48.李彥杰，葉郁欣，徐祥憲，黃克穠，任善隆，“AVR控制應用與實務”，高立，2006
49.http://www.medis-de.com/en/ppg.html
50.http://www.nellcor.com/
51.http://www.tbms.com.tw/chinese/material_a.asp