截至2012年的統計資料，癌症已經連續三十年蟬聯國人十大死因的榜首。為了使醫生能盡早發現腫瘤細胞，給予病人適當的治療，具有標靶特性的正子電腦斷層掃描儀便扮演了極重要的角色。由於正子攝影使用的標靶物具有放射性，需要藉由前端偵測器的改進，達成使用較少劑量獲得影像解析度及精準度提升的目標，減輕病人的輻射負擔。偵測器使用的元件包含將伽馬射線轉換成可見光的閃爍晶體和光子感測器，本研究製作了一套光子量測系統，經過LED測式輸入與輸出訊號之關係，確認本系統具有極高線性度(R2=0.9962)，並於初期利用此系統探討明晶光電公司生產的LYSO閃爍晶體與Hamamatsu S8550崩潰光電二極體之間的光傳導介面特性，內容包含晶體本身的光學隔離、晶體矩陣組裝、晶體和光電二極體的黏接，還有其與二極體偵測器的對位方式。本實驗所使用的隔離測試條件包含鐵氟龍溶液及鋁金屬，並且評估是否利用PDMS進行晶體和二極體之黏接。經量測結果發現，最適合的組裝方式為利用鋁金屬進行隔離，結合PDMS做元件黏接，此外實驗亦開發相關模具協助矩陣組裝，以及晶體和二極體的對位。最後，透過醫用標靶物FDG的實際測試，亦擁有一定的線性度(R2=0.9743)，並且驗證此量測系統應用於正子電腦斷層掃描儀的可行性。因此，本研究提供正子電子斷層掃瞄之關鍵感測元件的製作與量測，可作為日後關鍵感測元件更新研究之用。

From the statistics in 2012, cancer has been ranked the first among the top ten leading causes of death for the consecutive thirty years. In order to facilitate doctors to diagnose cancer in early days and give suitable treatments for the patients, the positron emission tomography (PET) has played an important role. However, the tracer in PET has certain degree of radiation. The objective of the research is to develop a PET detector to enhance image resolution and accuracy, as well as reducing the dosage usage of tracer. The research has produced a photons measurement system, confirmed by LED signal output test that it has quite high linearity (R2=0.9962) with different input voltage, and the detector includes scintillators for energy transforming and a photosensor. By using the light transmission unit, which consists of Cystalux Inc. made LYSO scintillators and Hamamatsu S8550 avalanche photodiode (APD), it is verified that the best fabrication method compared in the experiments is coating aluminum layer, together with the injecting PDMS between LYSO and APD. In addition, a simple and easy method for LYSO block fabrication and sensor alignment has been designed. Moreover, after doing the experiment with medical use tracer fluorodeoxyglucose (FDG), it is also shown with high linearity (R2=0.9743), and confirmed the detector is suitable for PET scanner applications.

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