磁性材料應用於生物組織之熱療已有數十年之研究，其中奈米磁粒電磁熱療的原理主要是使用直徑10到100 奈米之磁粒子 (如四氧化三鐵，Fe3O4) 將其放置於交變磁場下加熱至42 ℃以上，藉此達到殺死癌細胞，治療癌症的目的。奈米磁粒加熱系統研究有兩個主要方向：一是感應加熱系統的開發; 另一是感應線圈之磁場聚焦效果研究。本論文之目的為設計不同具體形狀之二維、三維感應線圈且藉由有限元素分析法 (FEM) 軟體模擬其磁場聚焦效果；最後並實際繞製線圈在半橋串聯諧振電路上作加熱實驗，比較量測數值與感應線圈模擬數值之磁場聚焦能力，結果顯示三角形和橢圓形線圈有更強的聚焦效果。因此線圈設計之結果在此被驗證是可行的。研究結果可做為未來奈米磁粒加熱系統設計之參考。

The application of magnetic materials for hyperthermia of biological tissue has been studied for decades. The underlying notion of magnetic nanoparticle (MNP) thermotherapy is to utilize 10- to 100-nm diameter of nanoparticles (eg. ferric oxide, Fe3O4) which are heated up to 42 ℃ under AC magnetic field for cancer therapy applications. The research of MNP heating system has two major concerns: one is the development of induction heating system; the other is the design of applicator coil to focus the magnetic field. The goal of this thesis is to design applicator coils that with various specific shapes and to simulate the coils by finite element method (FEM) software in two-dimensional (2-D) and three-dimensional (3-D) models. The comparison of the magnetic field focusing capability between simulated coils and real coils are verified from the experimental results by using a half-bridge series resonant circuit. The experimental results indicate that triangular and elliptical coils focus stronger magnetic fields. The results herein are demonstrated to be useful in the design of coils for MNP heating system application.

[1] M. D. Hurwitz, I. D. Kaplan, G. K. Svensson, M. S. Hansen, and K. Hynynen, "Feasibility and patient tolerance of a novel transrectal ultrasound hyperthermia system for treatment of prostate cancer," International Journal of Hyperthermia, vol. 17, pp. 31-37, 2001.
[2] V. Nagesh, C. I. Tsien, T. L. Chenevert, B. D. Ross, and H. S. Lawrence, "Radiation-Induced Changes In Normal-Appearing White Matter In Patients With Cerebral Tumors: A Diffusion Tensor Imaging Study," Int. J. Radiation Oncology,Biol.,Phys., vol. 70, pp. 1002-1010, 2008.
[3] F. Spreafico, L. Gandola, A. Marchiano, F. Simonetti, and G. Poggi, "Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors," Int. J. Radiation Oncology,Biol., Phys., vol. 70, pp. 1011-1019, 2008.
[4] I. Tannock, The basic science of oncology: McGraw-Hill Professional, 2005.
[5] P. Moroz, S. K. Jones, and B. N. Gray, "Magnetically mediated hyperthermia: current status and future directions," International Journal of Hyperthermia, vol. 18, pp. 267-284, 2002.
[6] 杜春艷, 劉繼光, 唐勁天, "加溫治療腫瘤的溫度與機體免疫關系," 中國微創外科雜志, vol. Vol.7 No.11, pp. P.1051-1053, 2007.
[7] P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, and P. M. Schlag, "Hyperthermia in combined treatment of cancer," Lancet Oncol, vol. 3, pp. 487-497, 2002.
[8] 郭中華, 唐露新, 唐勁天, 謝斌, 鄧曉慧, "交變磁場加熱治療腫瘤測控技術的研究進展," 中國醫療器械雜志, vol. Vol.30 No.1 2006.
[9] 陳俊成, "應用於奈米磁粒之半橋串聯諧振式雙頻耦合熱療加熱系統," 台南市: 國立成功大學電機研究所, 2008.
[10] "基隆市衛生局"， http://chmuseum.klchb.gov.tw/health_care_liver_23.aspx.
[11] E. J. Dede, J. Jordan, V. Esteve, J. M. Espi, and S. Casans, "Behaviour of series and parallel resonant inverters for inductionheating in short-circuit conditions," 2000, pp. 645-649 vol.2.
[12] L. R. Egan, E. P. Furlani, E. K. Co, and N. Y. Rochester, "A computer simulation of an induction heating system," IEEE Transactions on Magnetics, vol. 27, pp. 4343-4354, 1991.
[13] J. Davies and P. Simpson, Induction heating handbook: McGraw-Hill Companies, 1979.
[14] R. K. Gilchhist, W. D. Shorey, R. C. Hanselman, J. C. Pahbott, and C. B. Taylor, "Selective inductive heating of lymph nodes," Annals of Surgical Oncology, vol. 146, pp. 596-606, 1957.
[15] A. Jordan, R. Scholz, P. Wust, H. Fahling, J. Krause, W. Wlodarczyk, B. Sander, T. Vogl, and R. Felix, "Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo," International Journal of Hyperthermia, vol. 13, pp. 587-605, 1997.
[16] A. Jordan, P. Wust, R. Scholz, B. Tesche, H. Fahling, T. Mitrovics, T. Vogl, J. Cervos-Navarro, and R. Felix, "Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fields in vitro," International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, vol. 12, p. 705, 1996.
[17] A. Jordan, R. Scholz, P. Wust, H. FaKhling, and R. Felix, "Magnetic# uid hyperthermia (MFH): Cancer treatment with AC magnetic" eld induced excitation of biocompatible superparamagnetic nanoparticles," Journal of Magnetism and Magnetic Materials, vol. 201, pp. 413-419, 1999.
[18] A. Jordan, R. Scholz, P. Wust, H. Schirra, T. Schiestel, H. Schmidt, and R. Felix, "Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro," Journal of Magnetism and Magnetic Materials, vol. 194, pp. 185-196, 1999.
[19] A. Jordan, R. Scholz, K. M. Hauff, M. Johannsen, P. Wust, and J. Nadobny , "Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia," Journal of Magnetism and Magnetic Materials, vol. 225, pp. 118-126, 2001.
[20] D. K. Cheng, "Fundamentals of Engineering Electromagnetics," Wesley, 1993.
[21] S. Wada, L. Yue, K. Tazawa, I. Furuta, H. Nagae, S. Takemori, and T. Minamimura, "New local hyperthermia using dextran magnetite complex (DM) for oral cavity: experimental study in normal hamster tongue," Oral diseases, vol. 7, p. 192, 2001.
[22] R. E. Rosensweig, "Heating magnetic fluid with alternating magnetic field," Journal of Magnetism and Magnetic Materials, vol. 252, pp. 370-374, 2002.
[23] M. Yanase, M. Shinkai, H. Honda, T. Wakabayashi, J. Yoshida, and T. Kobayashi, "Intracellular hyperthermia for cancer using magnetite cationic liposomes: an in vivo study," Cancer Science, vol. 89, pp. 463-470, 1998.
[24] A. Ito, M. Shinkai, H. Honda, and T. Kobayashi, "Medical application of functionalized magnetic nanoparticles," Journal of bioscience and bioengineering, vol. 100, pp. 1-11, 2005.
[25] M. Suzuki, M. Shinkai, H. Honda, and T. Kobayashi, "Anticancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes," Melanoma Research, vol. 13, p. 129, 2003.
[26] 耿躍春, 王想想, "鐵磁熱籽導加熱治療肝癌的實驗研究," 中華理療雜誌, vol. 20, pp. 204-206, 1997.
[27] 陳建民, 熊國欣, "溫敏磁性材料居里點效應治療腫瘤的研究," 中國醫學物理學雜誌, vol. 17, pp. 101-102, 2000.
[28] 郭全忠, 吳亞, 孫劍飛, 顧寧, "磁流體熱療設備的三維電磁場模擬," 東南大學學報:自然科學版, vol. 34, pp. 336-339, 2004.
[29] 吳亞, 孫劍飛, 郭全忠, 顧寧, "腫瘤熱療用交變磁場發生器的研製," 東南大學學報:自然科學版, vol. 34, pp. 794-796, 2004.
[30] 何金滿, 莊富全, "具柔性切換高頻感應加熱器之實體製作," 中原學報 (自然科學及工程系列), vol. 27, pp. 83-87, 1999.
[31] 何金滿, 許國展, "應用於感應加熱的負載串聯共振電壓型反流器設計與研製," 中原學報 (自然科學及工程系列), vol. 31, pp. 263-270, 2003.
[32] 王榮爵, 張宏榮, "全橋式零電壓切換技術之感應加熱器," 華岡工程學報, pp. 145-154, 2007.
[33] 蘇信華, "磁奈米粒熱療感應加熱系統之研製," 台南市: 國立成功大學電機研究所, 2008.
[34] 王思婷, "具核殼結構的磁性微脂粒之熱效應研究," 台南市: 國立成功大學化學工程研究所, 2007.
[35] 蔡煥修, "磁性流體製程與性質之基礎研究," 台南市: 國立成功大學礦治及材料科學研究所, 1992.
[36] R. F. Soohoo, Theory and applications of ferrites: Prentice-Hall, Englewood Cliffs, NJ, 1960.
[37] 黃忠良, "磁性流體理論應用," 復漢出版社印行, 1989.
[38] B. D. Cullity and C. D. Graham, Introduction to magnetic materials: IEEE, 2008.
[39] 莊萬發, 超微粒子理論應用: 復漢出版社, 1995.
[40] J. Lee, T. Isobe, and M. Senna, "Preparation of ultrafine Fe3O4 particles by precipitation in the presence of PVA at high pH," JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 177, pp. 490–494, 1996.
[41] R. E. Rosensweig, "Ferrohydrodynamics Cambridge University Press," Cambridge, England, 1985.
[42] S. Chikazumi, S. Taketomi, M. Ukita, M. Mizukami, H. Miyajima, M. Setogawa, and Y. Kurihara, "Physics of magnetic fluids," Journal of Magnetism and Magnetic Materials, vol. 65, 1987.
[43] L. J. Segerlind, Applied finite element analysis: Wiley New York, 1976.
[44] 王新榮, 陳時錦, 劉亞忠, 有限元素法及其應用: 中央圖書出版社, 1997.
[45] "COMSOL Multiphysics 3.2 Electromagnetics Module User's Guide," 2005.
[46] 吳清水, 曾振東, 應用電磁學. 台北市: 全華科技圖書股份有限公司, 1997.
[47] D. K. Cheng, Field and wave electromagnetics: Addison-Wesley Reading, Mass, 1989.