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研究生: 謝鈞霖
Hsieh, Chun-Lin
論文名稱: 局部共線性引導的直系同源基因預測器
Local Synteny-Guided Orthology Predictor
指導教授: 吳謂勝
Wu, Wei-Sheng
學位類別: 碩士
Master
系所名稱: 電機資訊學院 - 電機工程學系
Department of Electrical Engineering
論文出版年: 2024
畢業學年度: 112
語文別: 中文
論文頁數: 63
中文關鍵詞: 直系同源基因局部共線性
外文關鍵詞: Ortholog, Local Synteny Analysis
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  • 摘要 II 誌謝 VIII 目錄 IX 表目錄 XII 圖目錄 XIV 第一章 研究背景與動機 1 1.1 同源基因介紹 1 1.1.1 尋找直系同源基因的重要性 2 1.1.2 尋找直系同源基因的困難 3 1.2 尋找直系同源基因方式 3 1.2.1 BLAST 3 1.2.2 OrthoFinder 6 1.3 GrosOMA 8 1.4 研究動機 9 1.5 研究目的 10 第二章 資料蒐集與處理 11 2.1 資料蒐集 11 2.2 基因體註解檔案( genomic.gff ) 12 2.2.1 基因表格(Gene table) 14 2.2.2 蛋白質序列檔(protein.faa)與RNA序列檔(rna.fna) 15 2.3 程式流程 16 2.4 資料處理 17 2.4.1 基因選擇Isoform代表 17 2.4.2 選擇Ortholog Candidate 19 2.4.3 Local Synteny資料處理 27 第三章 網站功能介紹 30 3.1 輸入頁面 30 3.2 結果頁面 32 3.3 搜尋Ortholog candidate 33 3.4 Local Synteny Analysis 34 3.5 案例分析 35 3.5.1 多個物種的Ortholog cascade 35 3.5.2 利用Local Synteny判斷Ortholog candidates 38 3.5.3 與OrthoFinder比較 42 第四章 結論與未來展望 44 4.1 結論 44 4.2 未來展望 44 參考文獻 45

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