表面增強拉曼散射（SERS）技術具有高靈敏度、良好選擇性和不需要複雜的樣品前處理，被廣泛應用於食品安全、化學傳感器、生物藥物分析和催化過程等領域。將半導體材料與金屬結合可進一步提升SERS基板性能並降低成本。半導體與金屬的混合能有效促進電子轉換，使SERS基板具有高靈敏性和多重檢測功能。半導體材料還具有自潔清洗功能，使SERS基板表面保持乾淨，減少干擾，提高準確性和靈敏度，同時提高基板的可重現性。大量生產中，利用更便宜的材料並實現大面積製造可以降低成本。本研究開發在大面積(直徑70mm)濾紙基板上吸附二氧化錫半導體奈米顆粒(L-SnO2-Au)，利用紫外照射讓電子電洞對複合使奈米金顆粒被還原並沉積，大基板能夠進行裁切變成小基板(直徑6mm)達到大量生產的目的。利用SEM、TEM、XRD和 EDS驗證二氧化錫上能夠成長出金奈米顆粒(50 nm-100 nm)，並且利用EDS Mapping可以看到奈米顆粒是均勻沉積於纖維素上。藉由裁切機器的基板能夠在紅光波段到近紅光外光的波長下拉曼(633 nm、671 nm、785 nm 和 1064 nm)檢測孔雀石綠、羅丹明 6G與4-硝基苯硫酚。在785nm拉曼下、本基板對於孔雀石綠檢測達到10-10並計算AEF達5.9x 108。不需要修飾就能夠選擇性捕獲揮發性(VOCs)如甲苯、苯甲醛、4-NTP、4-ATP與2-ATP，進而實現即時的SERS檢測。對於4-NTP氣體分子達到ppb的等級。此外，該基板藉由紫外光照射能夠重複性使用。基板具有高靈敏度、快速檢測和可重複使用的優點能夠廣泛的被應用。

Surface-enhanced Raman scattering (SERS) technology offers high sensitivity, excellent selectivity, and eliminates the need for complex sample preparation. It finds wide applications in areas such as food safety, chemical sensors, biomedical drug analysis, and catalytic processes. The combination of semiconductors and metals promotes electron transfer, enhancing sensitivity and enabling multiple detections, while the self-cleaning functionality of semiconductor materials maintains a clean surface, reducing interference and improving accuracy, sensitivity, and reproducibility of SERS substrates. In large-scale production, the use of cheaper materials and achieving large-area manufacturing can reduce costs. In this study, we developed a large-area (70 mm) paper-based substrate adsorbed with tin dioxide semiconductor nanoparticles (L-SnO2-Au) and utilized ultraviolet irradiation to induce electron-hole pair formation, reducing and depositing the nano-gold particles. The large substrate could be cut into smaller substrates (6 mm) for mass production purposes. The growth of gold nanoparticles on tin dioxide was confirmed using SEM, TEM, XRD, and EDS, while EDS mapping demonstrated the uniform deposition of nanoparticles on cellulose fibers.By using a cutting machine, the substrates were able to detect malachite green, Rhodamine 6G, and 4-nitrophenol in the red and near-infrared spectral range of Raman (633 nm, 671 nm, 785 nm, and 1064 nm). Under 785nm Raman excitation, the detection of malachite green reached 10-10, with a calculated enhancement factor (AEF) of 5.9x 108. Selective capture of volatile organic compounds (VOCs) such as toluene, benzaldehyde, 4-NTP, 4-ATP, and 2-ATP was achieved without the need for modification, enabling real-time SERS detection. The detection limit for 4-NTP gas molecules reached the ppb level. Additionally, the substrate could be reused through UV light irradiation. With high sensitivity, rapid detection, and reusability, the substrate can be widely applied.

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