近年來輔酶CoQ10被應用在生化、醫藥、食品、化妝品領域中。當CoQ10被還原後形成Ubiquinol-10則容易被氧化，本研究主要針對Ubiquinol-10上的氫氧根官能基做衍生化反應得到CoQ10的衍生物，並測試CoQ10與其衍生物的活性比較。
以氫氧根官能基做酯化反應為主，合成出acetylated CoQ10(ACoQ10)、octanoylated CoQ10(OCoQ10)、succinylated CoQ10(SCoQ10)、semi- succinylated CoQ10(semi-SCoQ10)以及phosphate CoQ10(PCoQ10)，其中ACoQ10、OCoQ10酯化反應是在鹼性條件進行，Ubiquinol-10與具有醯氯官能基反應，在室溫下反應時間只需30分鐘，得到的衍生物產率達95%以上，顯示以此方式進行酯化反應速率快、產率高。另外將CoQ10改變官能基後，發現其中SCoQ10、semi-SCoQ10、PCoQ10可以溶在醇類溶劑中，顯示衍生化的結果成功的將脂溶性的CoQ10，轉變具有親水性的結構。
每個衍生物除了可以保存在室溫中，經細胞抗氧化活性測試發現，semi-SCoQ10與PCoQ10的生物抗氧化能力比CoQ10好。

Coenzyme Q10 has been widely used in biochemistry recent years, including pharmaceutical﹑food and cosmetic fields. Ubiquinol-10 is the reduced form of CoQ10 which is easily oxidizied to CoQ10. The main purpose of the research is to prepare the derivatives of Ubiquinol-10 and examine their anti-oxidation activities.
A series of esterification modification has been performed on Ubiquinol-10 including acetylated CoQ10 (ACoQ10)﹑octanoylated CoQ10 (OCoQ10)﹑succinylated CoQ10 (SCoQ10)﹑semi-succinylated CoQ10 (semi-SCoQ10) and phosphate CoQ10 (PCoQ10). Esterification reactions of acetylated CoQ10 and octanoylated CoQ10 can be achieved under alkali condition. A milder esterification condition has been developed on the ubiquinol-10 by acetyl chloride reagents, the reaction can be achieved within 30 minutes and above 95% yield. It's a feasible method to produce ester derivatives at high reaction rate and yield.
In terms of the solubility of ubiquinol-10 modified compounds, the SCoQ10﹑semi-SCoQ10 and PCoQ10 can be dissolved in alcohol solvents, it means the derivatization results changed the hydrophobic CoQ10 to become more hydrophilic property.
Every derivatives are stable at room temperature and can be stored easily. Among the derivatives, the anti-oxidation activity of semi-SCoQ10﹑PCoQ10 are better than the others.

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