近年來，由於人類的壽命的延長，以及慢性病病患的逐漸增加，對於老人照顧及慢性病病患的健康檢測愈加受到重視，因此，利用簡易且快速的方式檢測病患的健康狀況是目前的發展趨勢。電化學阻抗頻譜分析法 (Electrical Impedance Spectroscopy, EIS)是目前常見的一種電化學檢測方式，本論文所提出應用於電化學阻抗頻譜量測系統的弦波峰值除法晶片，利用峰值偵測器、減法器並結合除法器，形成一可求得待測阻抗和已知阻抗上電壓資訊比值之晶片，強化前一版本 [9] 須分別量測兩次電壓資訊，再手動求出比值之缺點，此外，也修正系統因為受到零點 (zero)影響，使高頻雜訊嚴重汙染訊號，造成訊號信噪比(signal-to-noise ratio)不佳的問題。
本晶片使用台灣積體電路公司(TSMC) 0.35 µm 2P4M 3.3 V 混合訊號製程，以40 S/B封裝，尺寸為1.70×1.43 mm2，輸入訊號頻率範圍為10 Hz到10 kHz，輸入訊號振幅範圍為0.1 V到1 V，總功耗約為3.172 mW。

In recent years, home care of the elderly and the people who suffering from chronic diseases has drawn more and more attention. Therefore, using an easy and quick method to examine the patient’s health status at home becomes a trend nowadays. Electrochemical Impedance Spectroscopy (EIS) is a common electrochemical detection method, but traditional EIS instruments are large and expensive. Our research group has developed a small EIS measurement system. However, the previous version [9] could only measure the voltage information of sample under test (SUT) and reference module separately, and then manually calculate the voltage ratio between them. The proposed chip, which can be applied to EIS measurement systems, includes peak detectors, subtractors, and a divider. This chip is capable of obtaining the voltage ratio of reference module to SUT. In addition, the high-frequency noise due to an inherent zero in the EIS measurement system also causes a serious problem. Thus, this work also adds a pole to the system to compensate the impact of the zero and to increase the signal-to-noise ratio (SNR) of the system.
This chip was fabricated by using Taiwan Semiconductor Manufacturing Company (TSMC) 0.35μm 2P4M 3.3V mixed-signal polycide process. The die area of this chip is 1.70 x 1.43 mm2. The input frequency range of this chip is from 10 Hz to 50 kHz. The input amplitude range is from 0.1 V to 1 V. Total power consumption is 3.172 mW.

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