在今日，使用牙科植體來取代缺失的牙齒已變成一種常見的治療選擇。植體成功的關鍵在於其表面與周遭的齒槽骨能建立起骨整合。植體表面的設計、化學組成及型態會影響骨整合的程度。許多文獻指出噴砂加酸蝕處理(SLA)的表面有高骨頭與植體接觸的比例及高移除扭力值，可增進骨整合的能力。鍶(Sr)有抑制骨吸收及促進骨形成的能力，對於骨再生的應用是有助益的。鈦金屬經微弧氧化處理（MAO）具有極佳的生物相容性。故本實驗將觀察，在兔子脛骨植入以微弧氧化處理披覆鍶（MAO-Sr）之植體其骨整合情形並與噴砂加酸蝕處理(SLA)表面作比較。
將9隻紐西蘭兔的脛骨上植入不同表面處理之植體，分別是：微弧氧化處理（MAO）、微弧氧化處理披覆鍶（MAOSr）及噴砂加酸蝕處理(SLA)植體。植入後二星期，我們將先犧牲三隻兔子並利用逆轉錄聚合酶鏈式反應來觀察骨生成及骨吸收相關基因的表現量。植入後四星期，我們將犧牲其他兔子並切下脛骨製作切片來觀察植體與骨頭接觸情形，部份脛骨則進行功能性扭力測試。
在功能性扭力測試上三種表面處理之間並無顯著的差異性。然而在植體與骨頭接觸比例(BIC)方面，微弧氧化處理披覆鍶（MAOSr）的微植體有最好的結果。此外由逆轉錄聚合酶鏈式反應結果顯示經由MAOSr處理的微植體能提高骨生成相關基因的表現並同時抑制蝕骨相關基因的表現。
一言以蔽之，MAOSr的植體表面能促進骨生成並且抑制骨吸收。此外，相較於SLA及MAO的表面處理，MAOSr的表面處理對於鈦金屬微植體初期的骨整合反應是更有助益的。

Today, the use of dental implants has become a common treatment procedure in the replacement of missing teeth. The key of the success of dental implant is the establishment of osseointegration between implant surface and surrounding alveolar bone. The design, chemical composition and topography of the implant surface can influence the extent of osseointegration. Many literatures show that SLA(Sandblasted, Large grit, Acid-etched) surface improved osseointegration with a high percentage of bone-implant contact and high removal torque values. Strontium (Sr), which has the ability to inhibit bone resorption and stimulate bone formation, is beneficial for biological application for bone regeneration. The micro-arc oxidation (MAO) treatment of titanium (Ti) have a beneficial effect on the biocompatibility of the Ti implant. We aim to evaluate the response of implants with strontium coating by micro-arc oxidation (MAO-Sr) and compare the result of SLA surface in tibia of rabbits.
To prepare the animal study, 9 New Zealand white rabbits will be used. Three implants will be inserted into the each tibia of rabbits: MAO, MAOSr and SLA surface. At 2 weeks after implant insertion, 3 rabbits will be sacrificed. The tissue around implant will be removed for real-time polymerase chain reaction (RT-PCR). At 4 weeks after implant insertion, 6 rabbits will be sacrificed. The tibia will be removed for histomorphmetric analysis and removal torque assay. A bone-to-implant contact (BIC), functionally remove torque test and genes related to bone formation and resorption will be examined.
There was no significant differences in the removal torque values between SLA, MAO and MAOSr microimplants. However, the MAOSr microimplants had statistically significant higher bone-to-implant contact (BIC) than the SLA and MAO microimplants. There was no significant differences between the SLA and the MAO group. In RT-PCR analysis, increasing mRNA expression of osteogenesis-related genes (BSP, OCN, CD44 and CD73) was noted in the MAOSr group. In addition, down-regulating mRNA expression of the osteoclastogenesis-related genes (RANKL and RANK) and up-regulating the OPG expression was also noted in the MAOSr group.
The results indicate that the local delivery of strontium from the MAOSr surfaces can not only promote osteogenesis but also inhibit osteoclastogenesis by up-regulating the osteogenesis-related genes and down-regulating the osteoclastogenesis-related genes. The MAOSr surface can promote early osseointegration of the titanium microimplants comparing to the SLA and MAO surface.

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