磁性材料應用於生物組織之熱療已有數十年之研究，其中磁奈米粒熱療加熱系統主要是利用直徑10到50奈米的氧化鐵（Fe3O4），將其放置於交變磁場下加熱至42 ℃以上，藉此達到殺死癌細胞，治療癌症的目的。磁奈米粒的加熱效果會受到顆粒大小、磁場大小與頻率的影響，在系統的設計上必須設計一套效率高、磁場輻射集中且可變頻的電磁加熱系統。本研究使用高速數位微控制器(TI TMS320F28235)做為數位控制系統的核心，以脈波寬度調變技術控制全橋串聯諧振電路，精確地控制交變磁場的輸出頻率與功率，並經由磁奈米加熱實驗，發現顆粒大小10 nm磁奈米粒對於295 kHz附近的感應頻率有較佳的升溫反應，升溫可達13 ℃。

The application of magnetic materials for hyperthermia of biological tissue has been studied for decades. The underlying notion of magnetic nanoparticle (MNP) thermotherapy is to utilize 10- to 50-nm diameter of ferric oxide (Fe3O4) which are heated up to 42 ℃ under AC magnetic field for cancer therapy applications. The size of nanoparticles and the strength and frequency of magnetic field all have influence to the heating efficiency of MNP. In order to achieve the goal of killing cancer cells using the AC magnetic field, we designed a digital controlled heating system to generate magnetic field that is frequency adjustable. The core of the system is based on a high speed microcontroller（TI TMS320F28235）and a full-bridge series resonant circuit for the high frequency induction heater. The heating results show that the system can produce fast and accurate outputs. The experiments show that the MNP produces thermal loss and has maximum temperature increase up to 13 ℃ under a AC magnetic field. Finally, we discuss the heating effect of different density of magnetic nanoparticles under different operating frequency.

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