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研究生： 陳建良
Chen, Chien-Liang
論文名稱： 變頻半橋感應式磁奈米粒熱療加熱系統
A Frequency-Conversion Half-Bridge Induction Type Heating System for Magnetic Nanoparticle Thermotherapy
指導教授： 戴政祺
Tai, Cheng-Chi
學位類別： 碩士
Master
系所名稱： 電機資訊學院 - 電機工程學系
Department of Electrical Engineering
論文出版年： 2007
畢業學年度： 95
語文別： 中文
論文頁數： 70
中文關鍵詞： 熱療 、磁奈米粒 、半橋諧振 、有限元素法
外文關鍵詞： Thermotherapy, Magnetic nanoparticle, Half-bridge resonance, Finite-Element Method
相關次數： 點閱：60  下載：2 
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    • 利用微小磁粒在交變磁場下做熱療，大約是在1950年後期才開始的醫學研究。近十幾年來因磁粒的製程進步到奈米化，因此現今相關的醫學研究是利用磁奈米粒到人身體內做所謂的腫瘤熱療。其主要理念是使用磁奈米粒做為載體，包覆脂質與藥物的磁奈米粒會對特定癌細胞產生依附作用，再以外加的電磁加熱系統輻射出交變磁場，使磁奈米粒吸收磁能後轉成功率熱損而提升溫度，該熱能將使附載在磁奈米粒上的藥物發揮其療效在癌細胞上，並且利用高溫來達到抑制癌細胞的成長。至目前為止的磁奈米粒熱療研究都使用單一或者少數頻率與磁場大小來進行實驗，而這些相關之研究並沒有一個明確的最佳加熱模式，而加熱效率問題對於磁奈米粒熱療實驗是十分重要的。本研究的重點在於磁奈米粒加熱系統的設計，並實際針對未包覆藥物的磁奈米粒做磁場加溫實驗。本研究完成一個可輸入操作頻率的電路，利用半橋諧振電路來產生交流電流，經由鐵心上的感應線圈形成一磁路，產生磁場來對磁奈米粒加熱，利用變頻電路改變半橋諧振電路的諧振頻率，探討磁奈米粒在不同的加熱磁場頻率下之加熱特性。最後再利用有限元素法和電路模擬軟體進行串聯諧振電路模擬並與量測結果做比對，並且探討相同直徑磁奈米粒在不同操作頻率下的加熱效率關係。

    The Bio-research with small particles in AC magnetic fields was started in the late 1950s. Since the process of magnetic particles has progressed to nanoscale in the last decade, the related researches are doing tumor thermotherapy in human body with magnetic nanoparticles. The main idea is to use the magnetic nanoparticles which are packaged with lipid and drug to attach to specific cancer cells. The temperature of magnetic particles is risen by absorbing magnetic energy from external AC magnetic fields. The heat can make the good curative effects to cancer cells from drugs-bearing magnetic particles. And the high temperature can inhibit the development of cancer cells. Up to present, the thermotherapy researches of magnetic particles almost experiment with single or few frequencies of magnetic filed. So the focus of our research is to design the heating system to heat the magnetic particles. We design a half-bridge resonance circuit which can be set with different operation frequencies to generate the AC magnetic filed. The heating system can also control the amplitude of the generated magnetic field. Finally, we use the Finite-Element Method and circuit simulation software to simulate the half-bridge resonance circuit and compare the results with the practical heating system. The heating efficiency of nanoparticle under different heating frequencies is also studied.

    摘要 ............................................i Abstract .......................................ii 誌謝 ..........................................iii 目錄 ...........................................iv 表目錄 ........................................vii 圖目錄 .......................................viii 第一章 緒論 .....................................1 1.1 研究背景與動機 ............................1 1.2 相關文獻回顧 ..............................3 1.3 研究貢獻與目的 ............................4 1.4 全文概述 ..................................5 第二章 磁奈米粒的物理特性........................6 2.1磁性來源 ...................................6 2.1.1磁矩的產生 .............................6 2.1.2磁滯曲線 ...............................7 2.2磁區與粒徑的關係 ...........................9 2.2.1單磁區下的情形 ........................10 2.2.2多磁區下的情形 ........................12 2.3磁粒子功率損耗 ............................14 2.3.1氧化鐵功率損耗與粒徑與頻率關係.........15 2.3.2磁粒子功率損耗與頻率的關係 ............16 2.3.3理論上計算10 nm氧化鐵的最佳加溫頻率 ...17 第三章 系統設計 ................................18 3.1 前言 .....................................18 3.2 系統方塊圖 ...............................19 3.3 半橋串聯諧振式電路架構原理 ...............20 3.3.1半橋串聯諧振式電路架構 ................20 3.3.2半橋串聯諧振式電路操作原理 ............21 3.3.3半橋串聯諧振式換流器之元件設計 ........23 3.4 線圈設計理念與實現 .......................26 3.4.1電磁線圈磁路設計和線圈繞製 ............26 3.4.2 電磁線圈模擬電路 .....................30 3.5變頻控制系統...............................32 3.5.1切換頻率控制電路 ......................32 3.5.2半橋串聯諧振式電路之切換模式 ..........33 3.5.3 諧振頻率變頻原理和設計 ...............37 第四章 結果與討論 ..............................39 4.1實際電路 ..................................39 4.2模擬設計結果 ..............................42 4.2.1串聯諧振模擬電路 ......................42 4.2.2 諧振電路模擬結果 .....................43 4.3波形圖 ....................................47 4.3.1 實際電路中，操作頻率fs輸出波形 .......47 4.3.2 實際電路的輸出波形 ...................48 4.3.3 三個不同電容的輸出統計表 .............53 4.4加熱實驗 ..................................56 4.4.1 實驗A: 諧振電容(Cs)=5.5 nF ...........56 4.4.2 實驗B: 諧振電容(Cs) =12 nF ...........57 4.4.3 實驗C: 諧振電容(Cs) =18 nF ...........57 4.4.4 不同頻率下實驗加熱比較結果 ...........58 4.5加熱系統模擬與實驗結果討論.................59 4.6加熱實驗部份結果討論.......................59 第五章 結論和未來展望...........................61 5.1 結論 .....................................61 5.2 未來展望 .................................62 參考文獻........................................64 自述 ...........................................70

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