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研究生: 詹博凱
Chan, Po-Kai
論文名稱: 藉可調陷波響應之整合型微波平面共振腔量測脈搏傳輸時間以實現無壓脈帶血壓估測
Cuffless Blood Pressure Estimation from Pulse Transit Time Using Tunable Notch Response Integrated Microwave Planar Resonators
指導教授: 楊慶隆
Yang, Chin-Lung
學位類別: 碩士
Master
系所名稱: 電機資訊學院 - 電機工程學系
Department of Electrical Engineering
論文出版年: 2019
畢業學年度: 107
語文別: 中文
論文頁數: 65
中文關鍵詞: 振幅解調無壓脈帶血壓微波平面共振腔脈搏傳輸時間可調響應
外文關鍵詞: Amplitude demodulation, cuffless blood pressure, microwave planar resonator, pulse transit time, tunable response
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  • 本論文提出一全新之微波平面共振腔結構,供無壓脈帶血壓估測使用。其不僅延續振幅解調量測法之優勢,再藉由整合開口環形與互補式開口環形兩共振腔之感測區,使基於振幅法的感測表現進一步被提升,而可調陷波響應的應用,則使此表現被再次優化。雖本論文所提出之全新結構看似相當複雜,但已證明感測器之兩共振腔可獨立進行設計與分析。且基於模擬驗證之結果,本論文所提出之結構相較於典型的共振腔,品質因數將有157%以上的增加。而由穩定振動訊號的實際量測中,感測器之靈敏度的提升趨勢可被描述,而實際之提升效果,則可從振動幅度僅±3.5 µm的極微弱訊號量測結果中,訊雜比的9.34 dB提升得到證實。而血壓之估測部分,則是利用將本論文所提出之靈敏感測器,放置於頸動脈與橈動脈,量測脈搏傳輸時間的方式進行。此外本研究提出一套嚴謹之時間校正程序,使系統與電路產生之額外時間延遲低於0.1 ms。相關式之訓練結果,脈搏傳輸時間與血壓呈現高度負相關性,其相關係數至少優於−0.72。而基於此相關式之血壓估測結果也相當準確,其均方根誤差、平均絕對值偏差和平均誤差皆分別小於5.80、5.16和0.84 mmHg。此結果及意味著,微波感測技術於此全新生醫領域運用的成功,與被製程血壓監控之穿戴式裝置的潛力。

    This thesis proposes a novel microwave planar resonator as a sensor for cuffless blood pressure (BP) measurement, which applies an amplitude-modulated sensing technology for sensitively detecting BP. In this study, by integrating the sensitivity areas of both the split-ring resonator and complementary split-ring resonator, the performance of amplitude-based measurement can be improved and further enhanced by including a tunable notch design. Although the proposed sensor structure is complicated, the two resonators can be analyzed and well-designed individually. Based on the simulation, a quality factor enhancement of over 157% was observed compared with typical structures. Based on a test experiment of ultra-tiny vibration, sensitivity improvements were depicted. The signal-to-noise ratio was improved by 9.34 dB under ±3.5-µm perturbation detection. For BP measurement, the proposed sensitive sensors were used to detect the pulse transit time (PTT) between two channels corresponding to sensors upon carotid and radial arteries in a noncontact approach. The time difference error between the recorded channels was calibrated. The PTT and BP showed significantly negative correlation, and the correlation coefficient was better than −0.72. Based on the log-based relationship between PTT and BP, the BP was estimated accurately. The root mean square error, mean absolute difference, and mean error of the BP prediction were less than 5.80, 5.16, and 0.84 mmHg, respectively. The results expend a new biomedical application of microwave sensors and the potential of the proposed method in ubiquitous BP measurement.

    摘要 I Extended Abstract II 致謝 VIII 目錄 IX 圖目錄 XII 表目錄 XV 縮寫總表 XVI 第一章 緒論 1 1.1 研究動機與方向 1 1.2 背景與文獻回顧 3 1.2.1 連續血壓估測的發展 3 1.2.2 波速估測血壓之關係式 4 1.2.3 PTT與PAT的量測技術 7 1.3 論文架構 11 1.4 研究貢獻 13 第二章 微波平面共振腔感測器 14 2.1 微波平面共振腔之優勢 14 2.2 開口環形與互補式開口環形共振腔 14 2.3 等效電路模型與分析 16 2.4 共振腔之量測原理 20 2.4.1 典型(頻率偏移)量測法 20 2.4.2 振幅解調量測法 22 第三章 感測器與系統之設計分析 24 3.1 微波平面共振腔之優化探討 24 3.1.1 靈敏度提升驗證與陷波濾波器使用 24 3.1.2 固定式陷波之缺陷與改善方向 27 3.2 可調響應之整合型微波平面共振腔設計 28 3.2.1 SI-SRR之原型 30 3.2.2 SI-CSRR之原型 33 3.2.3 操作與共振頻率選擇 36 3.2.4 感測器之整合與實作 37 3.3 可調響應之整合型感測器靈敏度分析 40 3.3.1 動脈跳動模型設置 40 3.3.2 共振腔感測表現比較 41 3.4 量測系統設計 42 3.4.1 總系統簡介 42 3.4.2 子電路設計 43 第四章 實測驗證與血壓估測 45 4.1 實測穩定振動訊號之驗證 45 4.1.1 可調響應與靈敏度之關係 46 4.1.2 操作頻帶提升驗證 48 4.1.3 極微弱振動訊號量測 48 4.2 PTT實驗設置與流程 50 4.2.1 取樣時間差探討 52 4.2.2 實驗流程 52 4.2.3 訊號處理流程 53 4.3 血壓估測結果 56 4.3.1 PTT與血壓之相關性 56 4.3.2 血壓估測驗證 58 4.3.3 估測結果比較 59 第五章 結論與未來展望 61 5.1 結論 61 5.2 未來展望 62 參考文獻 63

    [1] W. B. Kannel, "Blood pressure as a cardiovascular risk factor: Prevention and treatment," Jama, vol. 275, no. 20, pp. 1571-1576, 1996.
    [2] 衛生福利部國民健康署 (2018). 三高防治專區-高血壓 [online]. Available: https://www.hpa.gov.tw/Pages/List.aspx?nodeid=1463
    [3] A. Frattola, G. Parati, C. Cuspidi, F. Albini, and G. Mancia, "Prognostic value of 24-hour blood pressure variability," Journal of hypertension, vol. 11, no. 10, pp. 1133-1137, 1993.
    [4] Keysight Technologies, "Basics of measuring the dielectric properties of materials," Published in USA, May 16, 2014.
    [5] D. Andreuccetti, R. Fossi, and C. Petrucci. (1997). An internet resource for the calculation of the dielectric properties of body tissues in the frequency range 10 Hz-100 GHz. [online]. Available: http://niremf.ifac.cnr.it/tissprop/
    [6] T.-C. Chang, C.-M. Hsu, K.-W. Chen, and C.-L. Yang, "Wearable sensors based on a high sensitive complementary split-ring resonator for accurate cardiorespiratory sign measurements," in 2017 IEEE MTT-S International Microwave Symposium (IMS), 2017, pp. 208-210.
    [7] C.-S. Lee, C.-Y. Wu, and Y.-L. Kuo, "Wearable bracelet belt resonators for noncontact wrist location and pulse detection," IEEE Transactions on Microwave Theory and Techniques, vol. 65, no. 11, pp. 4475-4482, 2017.
    [8] X. Ding et al., "Continuous blood pressure measurement from invasive to unobtrusive: Celebration of 200th birth anniversary of Carl Ludwig," IEEE Journal of Biomedical and Health Informatics, vol. 20, no. 6, pp. 1455-1465, 2016.
    [9] L. Peterson, R. Dripps, and G. Risman, "A method for recording the arterial pressure pulse and blood pressure in man," American heart journal, vol. 37, no. 5, pp. 771-782, 1949.
    [10] T. Sato, M. Nishinaga, A. Kawamoto, T. Ozawa, and H. Takatsuji, "Accuracy of a continuous blood pressure monitor based on arterial tonometry," Hypertension, vol. 21, no. 6_pt_1, pp. 866-874, 1993.
    [11] G. Molhoek et al., "Evaluation of the Penaz servo-plethysmo-manometer for the continuous, non-invasive measurement of finger blood pressure," Basic research in cardiology, vol. 79, no. 5, pp. 598-609, 1984.
    [12] R. Mukkamala et al., "Toward ubiquitous blood pressure monitoring via pulse transit time: Theory and practice," IEEE Transactions on Biomedical Engineering, vol. 62, no. 8, pp. 1879-1901, 2015.

    [13] S. L.-O. Martin et al., "Weighing scale-based pulse transit time is a superior marker of blood pressure than conventional pulse arrival time," Scientific reports, vol. 6, p. 39273, 2016.
    [14] E. Kazanavicius, R. Gircys, A. Vrubliauskas, and S. Lugin, "Mathematical methods for determining the foot point of the arterial pulse wave and evaluation of proposed methods," Information Technology and control, vol. 34, no. 1, 2005.
    [15] R. Kelly, C. Hayward, A. Avolio, and M. O'rourke, "Noninvasive determination of age-related changes in the human arterial pulse," Circulation, vol. 80, no. 6, pp. 1652-1659, 1989.
    [16] P. M. N, S. Karthik, J. Joseph, and M. Sivaprakasam, "Arterial blood pressure estimation from local pulse wave velocity using dual-element photoplethysmograph probe," IEEE Transactions on Instrumentation and Measurement, vol. 67, no. 6, pp. 1399-1408, 2018.
    [17] D. Buxi, J. Redouté, and M. R. Yuce, "Blood pressure estimation using pulse transit time from bioimpedance and continuous wave radar," IEEE Transactions on Biomedical Engineering, vol. 64, no. 4, pp. 917-927, 2017.
    [18] Y. Yoon, J. H. Cho, and G. Yoon, "Non-constrained blood pressure monitoring using ECG and PPG for personal healthcare," Journal of medical systems, vol. 33, no. 4, pp. 261-266, 2009.
    [19] J. Solà et al., "Noninvasive and nonocclusive blood pressure estimation via a chest sensor," IEEE Transactions on Biomedical Engineering, vol. 60, no. 12, pp. 3505-3513, 2013.
    [20] A. Esmaili, M. Kachuee, and M. Shabany, "Nonlinear cuffless blood pressure estimation of healthy subjects using pulse transit time and arrival time," IEEE Transactions on Instrumentation and Measurement, vol. 66, no. 12, pp. 3299-3308, 2017.
    [21] C. Li, J. Cummings, J. Lam, E. Graves, and W. Wu, "Radar remote monitoring of vital signs," IEEE Microwave Magazine, vol. 10, no. 1, pp. 47-56, 2009.
    [22] M. S. Boybay and O. M. Ramahi, "Material characterization using complementary split-ring resonators," IEEE Transactions on Instrumentation and Measurement, vol. 61, no. 11, pp. 3039-3046, 2012.
    [23] C.-S. Lee and C.-L. Yang, "Single-compound complementary split-ring resonator for simultaneously measuring the permittivity and thickness of dual-layer dielectric materials," IEEE Transactions on Microwave Theory and Techniques, vol. 63, no. 6, pp. 2010-2023, 2015.
    [24] J. D. Baena et al., "Equivalent-circuit models for split-ring resonators and complementary split-ring resonators coupled to planar transmission lines," IEEE Transactions on Microwave Theory and Techniques, vol. 53, no. 4, pp. 1451-1461, 2005.
    [25] J.-S. Hong, Microstrip filters for RF/microwave applications, 2nd ed. John Wiley & Sons, 2011, p. 76.
    [26] K. B. S. Kiran, S. Brahma, S. K. Parida, and R. K. Behera, "Analysis of inductive resonant coupled WPT system using reflected load theory," in 2014 IEEE International Conference on Power Electronics, Drives and Energy Systems (PEDES), 2014, pp. 1-6.
    [27] C. Herrojo, J. Mata-Contreras, A. Núñez, F. Paredes, E. Ramon, and F. Martín, "Near-field chipless-RFID system with high data capacity for security and authentication applications," IEEE Transactions on Microwave Theory and Techniques, vol. 65, no. 12, pp. 5298-5308, 2017.
    [28] D. M. Pozar, Microwave Engineering, 4th ed. Wiley, 2011, p. 306.
    [29] C.-L. Yang, C.-S. Lee, K.-W. Chen, and K.-Z. Chen, "Noncontact measurement of complex permittivity and thickness by using planar resonators," IEEE Transactions on Microwave Theory and Techniques, vol. 64, no. 1, pp. 247-257, 2016.
    [30] P.-K. Chan, C.-C. Chen, and C.-L. Yang, "Systolic and diastolic blood pressure estimation from pulse transit time using dual split-ring resonators with notch structure " in 2019 IEEE MTT-S International Microwave Symposium (IMS), 2019.
    [31] J. S. Sun, N. Kaneda, Y. Baeyens, T. Itoh, and Y. Chen, "Multilayer planar tunable filter with very wide tuning bandwidth," IEEE Transactions on Microwave Theory and Techniques, vol. 59, no. 11, pp. 2864-2871, 2011.
    [32] A. Velez, J. Bonache, and F. Martin, "Varactor-loaded complementary split ring resonators (VLCSRR) and their application to tunable metamaterial transmission lines," IEEE Microwave and Wireless Components Letters, vol. 18, no. 1, pp. 28-30, 2008.
    [33] H. Alexander, Miller, and DL, "Determining skin thickness with pulsed ultra sound," Journal of Investigative Dermatology, vol. 72, no. 1, pp. 17-19, 1979.
    [34] S. Laurent et al., "Elastic modulus of the radial artery wall material is not increased in patients with essential hypertension," Arteriosclerosis and thrombosis: a journal of vascular biology, vol. 14, no. 7, pp. 1223-1231, 1994.
    [35] T. Karacolak, R. Cooper, E. S. Unlu, and E. Topsakal, "Dielectric properties of porcine skin tissue and in vivo testing of implantable antennas using pigs as model animals," IEEE Antennas and Wireless Propagation Letters, vol. 11, pp. 1686-1689, 2012.
    [36] Electronic or Automated Sphygmomanometers, ANSI/AAMI Standard SP10-192, ed. Arlington, VA, USA, 1993.

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