中風後的人群中約有33%的患者會患有失語症，導致語言能力的喪失。功能連接性（Functional Connectivity, FC）通過分析BOLD訊號的相關性來測量腦區之間的同步活動，對理解大腦網絡動態具有重要意義。本研究使用fMRI評估失語症患者在治療前、治療後和停止治個月後的功能連接性變化，並選取主要語言相關腦區進行分析，探討語言治療對腦功能連接性的影響及其持續性。受試者在為期3個月的訓練後，會發現腦部開始產生補償性重塑。在治療後命名能力增加，但停止治療後命名能力大幅度下降的患者中發現左側IFG與左側Thalamus、左側superior frontal gyrus (SFG)與左側supramarginal、左側middle temporal gyrus (MTG)與左側temporal pole superior temporal gyrus (STG)、左側insula與右側 lenticular nucleus以及右側inferior parietal gyrus (IPG)與右側orbital part of superior frontal gyrus (SFG)之間的連結，在治療後都會大幅上升，然而在停止之療後，這些代償的連結消失，導致患者無法持續地維持命名能力。另外也發現，在語言的恢復上，大腦會傾向right superior frontal gyrus與left inferior temporal gyrus之間的連結。命名能力較差的時候right superior frontal gyrus與left inferior temporal gyrus之間的連結都很高，但是命名能力變好的時候都會降低。透過了解患者的功能性代償作用，可以了解患者在語言能力恢復上的變化，以此調整治療方式，以達到更好的治療效果。

About 33% of people who have had a stroke will suffer from aphasia, resulting in the loss of language ability. Functional Connectivity (FC) measures synchronous activity between brain regions by analyzing the correlation of BOLD signals, which is crucial for understanding brain network dynamics. This study uses fMRI to evaluate the changes in functional connectivity of patients with aphasia before treatment, after treatment, and 3 months after treatment discontinued. We select the main language-related brain areas for analysis to explore the impact and persistence of language therapy on brain functional connectivity. After three months of training, patients' brains start to undergo compensatory remodeling. In patients whose naming ability increased after treatment but decreased significantly after treatment discontinued, it was found that the connections between the left IFG and the left thalamus, the left SFG and the left supramarginal gyrus, the left MTG and the left STG, the left insula and the right lenticular nucleus, and the right IPG and the right SFG all significantly improved after treatment. However, these compensatory connections disappeared after treatment discontinued, leading to a decline in naming ability. Additionally, language recovery tends to connect the right SFG and the left ITG. When naming ability is poor, the connection between the right SFG and the left ITG is very high, but when naming ability improves, the connection decreases. Understanding these functional compensations helps us adjust treatment methods for better results.

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