在真核生物中，基因表現的轉錄調控通常是合作轉錄因子們進行合作調控來實現。因此，有一個能提供合作轉錄因子們和共同調控基因之間關係的資料庫將有助於生物學家研究基因表現的轉錄調控的分子機制。但目前並沒有這類的資料庫能觀察合作轉錄因子和基因之間的關係，因此，我們開發Yeast Combinatorial Regulation Database (YCRD)來提供合作轉錄因子對和調控目標基因的資料。在YCRD中我們收集了2,622個合作轉錄因子對(cooperative transcription factor pairs)和6,243個基因。這些2,622個合作轉錄因子對是從文獻中17個演算法整理出來的。我們把TF1和TF2共同目標基因定義為這些合作轉錄因子對的目標基因，而這些轉錄因子和目標基因調控關係資料是從YEASTRACT資料庫取得。在YCRD 使用者能(1)搜尋基因和哪些合作轉錄因子對有關，(2) 搜尋合作轉錄因子對調控哪些基因，(3)識別一群基因被哪些重要合作轉錄因子對調控。我們相信YCRD有利於研究酵母菌基因的組合調控。

In eukaryotes, the transcriptional regulation of gene expression is usually controlled by cooperative transcription factors. Therefore, we need a database that provides the relationships between cooperative transcription factors and target genes. Because there is no existing database providing the relationships between cooperative transcription factors and target genes, we developed Yeast Combinatorial Regulation Database (YCRD) in this study. In YCRD, we collected 2,622 cooperative transcription factor pairs and 6,243 genes’ information. The cooperative transcription factor pairs’ information was collected from 17 algorithms. We defined a cooperative transcription factor pair’s target genes as the common target genes of the two TFs of a cooperative transcription factor pair. In YCRD, (i) users can search the relationship between cooperative transcription factor pairs and target genes, and (ii) users can identify a set of genes which are regulated by important cooperative transcription factor pairs. Finally, we believe YCRD is useful for studying combinatorial regulation of yeast genes.

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