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研究生: 陳仰豪
Chen, Yang-Han
論文名稱: 多頻段感應加熱系統設計與大電流感測應用
Design of Multi-Frequency Induction Heating Machine and the Application of High-Current Transducer for Long-Term Operation
指導教授: 戴政祺
Tai, Cheng-Chi
學位類別: 碩士
Master
系所名稱: 電機資訊學院 - 電機工程學系
Department of Electrical Engineering
論文出版年: 2013
畢業學年度: 101
語文別: 中文
論文頁數: 69
中文關鍵詞: 電磁熱療高週波電流感測器
外文關鍵詞: Electromagnetic hyperthermia, Induction heating system, Current sensor
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  • 奈米磁粒電磁熱療是先將具有磁性的奈米粒子注射進入人體腫瘤細胞附近,使腫瘤細胞吸收這些奈米粒子,接著在體外產生一個交變磁場,對體內的奈米磁粒加熱到達45℃達到殺死腫瘤細胞的目的。奈米磁粒的加熱效果會受到顆粒大小、磁場大小與頻率的影響。由於硬體的結構限制了磁場增加的能力,因此為了能增加溫度上升的效率,本研究利用不同的電容與電感搭配設計一台可變換頻段的感應加熱器。經過實驗證明,當頻率越高奈米磁粒的溫升效果就越好。另外本次也將研究如何長時間感測大電流,進而達到長時間機台的監測,使機台可以更加被使用者所掌握,並且達到醫療儀器所要求的安全性。

    In the operation of tumor hyperthermia, magnetic nanoparticles (MNP) are injected into the tumor cells. After that the induction heating system generates the alternating magnetic field to heat these MNP up to 45°C to destroy the tumor cells. The size of MNP and the strength and frequency of magnetic field all have influence on the heating efficiency. It was found that the strength changeability of the magnetic field was limited by the existed hardware configuration. This thesis utilized the combination structure of capacitance and inductance to modify the induction heating device with variable frequency to improve the efficiency of the temperature rise. Experiments showed that the higher the frequency is, the better the temperature rise effects result in. In addition, this study also developed high current sensing method to detect the several hundred-Ampere currents in the coils for the feedback control to have the medical instrument last longer and to enhance the security in operation.

    目錄 摘 要 I Abstract II 誌謝 III 目錄 IV 圖目錄 VI 表目錄 IX 第一章 緒論 1 1-1 研究背景 1 1-2 國內外文獻回顧 2 1-3 研究動機與目的 4 1-4 論文架構 4 第二章 基礎理論介紹 6 2-1 簡介 6 2-2 奈米磁粒特性 6 2-3 LCR諧振電路 8 2-3-1 LCR並聯諧振電路 8 2-3-2 LCR串聯諧振電路 11 2-4 電流感測器 13 第三章 多頻段感應加熱機設計 15 3-1 簡介 15 3-2 機台設計 16 3-2-1 變壓器 17 3-2-2 手動可調電容箱 18 3-3 改裝後問題 20 3-4 機台模擬 22 第四章 大電流感測 26 4-1 簡介 26 4-2 感應線圈與負載電阻 26 4-3 後端訊號處理 28 第五章 模擬測試結果與討論 35 5-1 奈米磁熱療系統模擬與實測 36 5-2 電流感測器測試 46 5-1-1不同頻率同電流測試 47 5-1-2 長時間電流感測測試 52 5-3 實驗結果討論 56 第六章 小鋼珠及奈米磁粒加熱實驗 57 6-1 小鋼珠加熱實驗 57 6-2 奈米磁粒加熱實驗 58 6-2-1同電流、線圈不同頻率加熱實驗 60 6-2-2同電流、頻段不同線圈加熱實驗 60 6-2-3同頻段、線圈不同電流加熱實驗 61 6-3 實驗結果討論 62 第七章 結論與未來展望 63 7-1 結論 63 7-2 未來展望 64 參考文獻 66 自述 69

    參考文獻
    [1] G. J. Gordon, Bioinformatics in cancer and cancer therapy, Totowa, NJ: Humana, 2009.
    [2] M. Schwab, Encyclopedia of cancer, New York: Springer, 2009.
    [3] 張梅蘭,物理因子治療學 冷、熱光、水療及機械性治療,合記出版社,民國九十一年。
    [4] B. Ribba, B. You, M. Tod, P. Girard, B. Tranchand, V. Trillet-Lenoir, and G. Freyer, "Chemotherapy may be delivered based on an integrated view of tumour dynamics," IET, vol. 3, pp. 180-190, 2009.
    [5] C. A. Sawyer, A. H. Habib, K. Miller, K. N. Collier, C. L. Ondeck, and M. E. McHenry, "Modeling of temperature profile during magnetic thermotherapy for cancer treatment," Journal of Applied Physics, vol. 105, pp. 07B320-07B320-3, 2009.
    [6] L. Yong, K. S. Leung, and T. S. K. Mok, "A novel evolutionary drug scheduling model in cancer chemotherapy," IEEE Transactions on Information Technology in Biomedicine, vol. 10, pp. 237-245, 2006.
    [7] X. Wang, J. Tang, and L. Shi, "Induction Heating of Magnetic Fluids for Hyperthermia Treatment," IEEE Transactions on Magnetics, vol. 46, pp. 1043-1051, 2010.
    [8] F. Wu, W. Chen, J. Bai, J. Zou, Z. Wang, H. Zhu, and Z. Wang, "Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies," Ultrasound in medicine & biology, vol. 28, pp. 535-542, 2002.
    [9] R. Gilchrist, R. Medal, W. Shorey, R. Hanselman, J. Parrott, and C. Taylor, "Selective inductive heating of lymph nodes," Annals of Surgery, vol. 146, pp. 596-606, 1957
    [10] P. Moroz, S. K. Jones, B. N. Gray, “Magnetically mediated hyperthermia: current status and future directions,” INT. J. Hyperthermia, vol. 18, no. 4, pp. 267-284, 2002
    [11] A. Jordan, R. Scholz, P. Wust, H. Fähling, and F. Roland, "Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles," Journal of Magnetism and Magnetic Materials, vol. 201, pp. 413-419, 1999.
    [12] A. Jordan, R. Scholz, K. Maier-Hauff, M. Johannsen, P. Wust, J. Nadobny, H. Schirra, H. Schmidt, S. Deger, S. Loening, W. Lanksch, and R. Felix, "Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia," Journal of Magnetism and Magnetic Materials, vol. 225, pp. 118-126, 2001.
    [13] 陳建璋,「半橋串聯共振式磁奈米粒熱療加熱系統研製」,國立成功大學電機工程學系碩士論文,2007。
    [14] 孔維彬,「以有限元素分析法作感應加熱線圈分析」,國立成功大學電機工程學系碩士論文,2008。
    [15] 林子翔,「奈米粒熱療加熱系統之中低頻磁場聚焦探頭設計」,國立成功大學電機工程學系碩士論文, 2009。
    [16] 蘇信華,「奈米磁粒熱療感應加熱系統之研製」,國立成功大學電機工程學系碩士論文,2008。
    [17] 徐彬翔,「高頻感應加熱器之DSP數位控制設計」,國立成功大學電機工程學系碩士論文,2011。
    [18] 陳勁克,「以DSP建構數位監控系統於腫瘤電磁熱療系統」,國立成功大學電機工程學系碩士論文, 2011。
    [19] 曾名弘,「奈米粒熱療加熱系統之模擬與探頭模型分析」,國立成功大學電機工程學系碩士論文, 2011。
    [20] 吳明璋,「大功率電磁熱療系統之數位回授溫度控制」,國立成功大學電機工程學系碩士論文,2012。
    [21] 游本傳,「15-kW數位控制式高週波加熱系統之自動頻率追蹤」,國立成功大學電機工程學系碩士論文,2012。
    [22] 曾子庭,「電磁熱療系統之即時數位電流回授控制」,國立成功大學電機工程學系碩士論文,2012。
    [23] 莊萬發,“超微粒子理論影用”,復漢出版社,民國八十四年。
    [24] 陳俊成,“應用於奈米磁粒之半橋串聯諧振式雙頻耦合熱療加熱系統”,國立成功大學電機工程系碩士論文,民國九十七年。
    [25] R. Hergt, W. Andra, C. d'Ambly, I. Hilger, W. Kaiser, U. Richter, and H. Schmidt, "Physical limits of hyperthermia using magnetite fine particles," IEEE Transactions on Magnetics, vol. 34, pp. 3745-3754, 1998.
    [26] K. W. E. Cheng, W. S. Lee, C. Y. Tang, and L. C. Chan, "Dynamic modelling of magnetic materials for high frequency applications," Journal of Materials Processing Technology, vol. 139, 2003.
    [27] R. Rosensweig, "Heating magnetic fluid with alternating magnetic field," Journal of Magnetism and Magnetic Materials, vol. 252, pp. 370-374, 2002.
    [28] P. Fannin and S. Charles, "The study of a ferrofluid exhibiting both Brownian and Neel relaxation," Journal of Physics D: Applied Physics, vol. 22, pp. 187-191, 1989.
    [29] I. Hilger, R. Hergt, and W. Kaiser, "Use of magnetic nanoparticle heating in the treatment of breast cancer," IEE Proc-Nanobiotechnol, vol. 152,pp. 33-39, 2005.
    [30] K. I. Hwu and Y. T. Yau, "Improvement of one-comparator counter-based PFM control for DC-DC converter," IEEE International Symposium on Industrial Electronics, pp. 1604-1607, 2009.
    [31] Y. S. Shin, Chang-Seop Kim, and Sang-Kyoo Han, "A pulse frequency modulated full bridge DC/DC converter with series boost capacitor," IEEE Transactions on Industrial Electronics, vol. 58, pp. 5154-5162, 2011.
    [32] 梁適安,「交換式電源供給器之理論與實務設計」,全華出版社,2008。
    [33] 張天錫,「電力電子學」,東華書局,2010。
    [34] 張英彬、科聖浩,「電子安定器之實作技術」,新文京開發出版股份有限公司,2006。
    [35] 李海發、王岩、陳盟仁,「電機機械」,全華出版社,1995。
    [36] Dino Zorbas、傅維譚、蔡仁鋼,「電機機械」,儒林出版,1993。
    [37] D. A. Douglass, "Current transformer accuracy with astmmetric and high frequency fault currents," IEEE Transactions on Power Apparatus and Systems, vol. PAS-100, pp. 1006-1020, 1981.

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