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研究生： 侯尚佑
Hou, Shang-You
論文名稱： 脊髓損傷大白鼠之復健程度評估系統之研製
The Assessment System on Rehabilitation Degree for Spinal Cord Injured Rats
指導教授： 楊明興
Young, Ming-Shing
學位類別： 碩士
Master
系所名稱： 電機資訊學院 - 電機工程學系
Department of Electrical Engineering
論文出版年： 2009
畢業學年度： 97
語文別： 中文
論文頁數： 72
中文關鍵詞： 脊髓損傷 、BBB 計分方式 、動物實驗 、荷重量測系統
外文關鍵詞： spinal cord injury, BBB Score, force sensor measurement system, animal test
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    • 動物實驗在神經醫學、病理生理學及藥物治療研究上扮演一個很重要的地位。而在大白鼠的脊髓損傷模型中，所引起的後肢癱瘓、肌肉無力等現象在臨床醫學上和脊髓損傷病人是十分相似的。所以在這方面的醫學研究都是以大白鼠的脊髓損傷模型為主。過去數十年來，已發展出許多方法以評估脊髓損傷之大白鼠在藥物治療或復健治療後復原的程度。
    本論文主要是針對大白鼠運動功能回復程度研發出一套荷重量測系統，本量測系統以微控制器為核心配合自行設計的踏板機構以量測老鼠四肢及臀腹部的重量，將所量測到的資料傳送至PC顯示及儲存，再計算臀腹部佔全身重量的百分比以評估復原的程度。本系統經過多隻大白鼠實驗，其結果與人工觀察的BBB計分方式是一致的。

    The animal test plays an important role in Neurology, Pathophysiology study and development of drug therapies. In animal model of spinal cord injury, the feature is hindlimbs paralysis, muscle weakness, the behavioral responses in animal model should be relevant to the clinical signs of spinal cord injury in human patients. There were many various methods had been developed to examine the motor function and behavioral recovery after drug therapies or rehabilitation following the spinal cord injury of rats.
    In this study, we develop a force sensor measurement system for evaluate the motor function of rat after spinal cord injury . The system is built around a microcontroller and use the strain gauge as the force sensor to measure the limbs weight and hindquarter weight. The system has a RS232 port allows connection to a PC, so data can be sent directly to hard disk for storage and analysis. After calculating the weight percentage of hindlimbs and hindquarter, it is easy to distinguish the degree of motor function recovery. The results of the force sensor measurement system compare with the results of BBB score is same.

    中文摘要....................................................Ⅰ 英文摘要....................................................Ⅱ 謝誌........................................................Ⅳ 目錄........................................................Ⅴ表目錄......................................................Ⅷ圖目錄......................................................Ⅸ 第一章 緒論...............................................1 1-1前言...............................................1 1-2相關研究回顧.......................................3 1-3研究動機與目的.......................................7 1-4論文架構.............................................9 第二章 系統架構與設計......................................10 2-1系統架構概觀........................................10 2-2踏板機構與形變計(strain gage)的量測原理.............13 2-2-1荷重系統量測原理...............................13 2-2-2 應變規原理及介紹..............................14 2-2-3 以應變規進行應變量測..........................17 2-2-4避免導線電阻產生錯誤-使用三線式應變規..........19 2-3電源穩壓電路........................................21 2-4類比訊號前置放大濾波電路............................22 2-4-1儀表放大器....................................22 　 2-4-2二階主動低動濾波器及正相放大器................23 2-5微控制器系統控制電路................................25 2-5-1 微控制器、類比開關及ADC電路.................. 26 2-5-2 RS232C 串列傳輸介面.......................... 29 2-6軟體設計............................................31 2-6-1微控制器韌體程式設計..........................31 2-6-2 Labview 人機界面程式..........................33 第三章 系統驗証與問題討論...................................35 3-1 系統驗証...........................................35 3-2 問題討論...........................................40 第四章 實驗流程與數據統計分析............................45 4-1 實驗方法與流程.....................................47 4-2 實驗數據與結果.....................................52 第五章 結論與未來展望......................................56 5-1 結論...............................................56 5-2 未來展望...........................................57 參考文獻....................................................58 附錄A AD620上視圖及內部功能方塊圖...........................62 附錄B TL074運算放大器之頂視圖及內部功能方塊圖...............63 附錄C類比開關4067...........................................64 附錄D ADS8325上視圖及內部功能方塊圖.........................65 附錄E 附錄E ATMEGA8535...................................... 66 附錄F TLV1117上視圖及內部功能方塊圖.........................68 附錄G BBB Score..............................................69

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