根據統計，2006年台灣十大惡性腫瘤中，口腔癌排名第六，每年因口腔癌而死亡的人數高達上千人。生物電阻抗是一種電阻抗測量技術，極具臨床應用潛力。由於組織電特性會隨著頻率有所變化，不同頻率之電阻抗變化可以提供不同資訊，許多組織在正常和異常狀態時會顯示出不同的電特性，因此多頻率的生物電阻抗測量有其重要性。本研究主要是研發出一套具有多頻率生物電阻抗測量系統並且結合嵌入式系統平台應用在口腔組織阻抗的量測，其三個主要的部份，一為硬體設計，二為軟體設計，三則為支架輔具的設計。在硬體架構的設計包含二個部份，(1)嵌入式系統平台，與(2)量測模組。軟體功能上主要分為三個主要部份，(1)Board Support Package(BSP)的設定，(2)阻抗測量參數設定，與(3)數據擷取。本論文所研發系統的特性綜合如下，系統的總諧波失真(THD)約為0.3%。阻抗測量實驗結果，與Agilent 4263B 阻抗測量儀比較，在測量精密電阻方面，其最大差異誤差低於2%；在口腔組織量測，實驗結果也有很好的再現性。本系統在組織的多頻率測量上，比阻抗測量儀提供更多的頻率點的測量，並且與嵌入式系統平台作結合，可在WinCE 作業系統下執行之分析程序，採用觸控螢幕作為顯示及圖形操作的控制介面，可以降低操作的複雜度。

Oral cancer is the sixth causes of death in 2006 among the ten major malignancies in Taiwan. Every year it makes thousands people die. Bioimpedance technology is a kind of impedance measurement technology, and has great potential in clinical applications. Due to the property of tissues, the impedance may vary with the frequency of measuring signal. Many tissues show the different electrical properties between the normal and malignant states. Thus, the multi-frequency impedance measurement plays an important role in characterizing the electrical property of tissues. This study has developed a set of multi-frequency bio-impedance measuring system that provides oral tissue impedance measurement on an embedded system platform. Its three major parts combine: first, hardware design; second, software design; and third, assistive device design. Hardware design contains two parts which are: (1)Embedded System Platform, and (2)measurement module. Its software functions contain three major parts which are: (1)Board Support Package(BSP)configuration, and (2)measurement parameter settings, and (3)data acquisition. The performances for the developed system are summarized as follows. The total harmonic distortion(THD) is below 0.3%. The experimental results of bioimpedances are also compared with the Agilent 4263B LCR meter. For the standard resistor measurement, the maximal percentage difference between the proposed system and LCR meter is within 2%. For the oral tissue measurement, the experimental results of bioimpedances have also good reproducibility in impedance measurements. This developed system provides more frequent point measurement than LCR meter, and combined with embedded system platform, it can perform analysis program in WinCE operation system that require touch panel screen and GUI control panel to reduces its complexity to operate.

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