四氧化三鐵(Fe3O4)磁性奈米粒子因其具有獨特的特性，如超順磁性與生物相容性，在生物醫學領域具有廣闊的應用前景。癌症已蟬聯國人十大死因之首26年了，因此許多生醫上面的研究多著重於開發新技術應用於癌症的治療。
在高頻交流磁場下，氧化鐵磁性奈米粒子因磁滯損耗所產生熱能可以用於臨床上對於腫瘤組織的高溫熱療法。一般溫度高於42℃即可殺死癌細胞。此種熱治療的表現與效率與癌細胞的種類以及氧化鐵磁性奈米粒子的大小、粒徑分佈、表面官能基有關。本研究利用化學共沈澱法與水熱合成法成功的製備四氧化三鐵磁性奈米粒子，粒徑大約20-30nm左右。且利用葡萄糖酸內酯(D-(+)-gluconic acid δ-lactone)表面修飾為親水性，比起傳統的化學共沈澱法所製備之四氧化三鐵在相同的磁場下可以提供更多的熱能，實驗結果顯示自製的磁性流體在濃度5.6 mg Fe3O4/0.2ml DI-Water，15分鐘內可以提昇溫度到70℃以上，具有良好的升溫能力。
此外研究也利用本實驗室開發中的噴霧流化床法製備肌紅蛋白分子模版，肌紅蛋白主要分佈於心肌與骨骼中，負責儲存氧分子與運送氧分子至肌肉組織。當心肌受損時，肌紅蛋白會迅速釋放至血液中，可以作為心肌梗塞早期的標幟物，當胸痛發生後3-6小時後，可以藉由檢測肌紅蛋白於人體的濃度是否超過正常值來判斷心肌梗塞發生的可能性。先前的研究已證實TEGDMA和MMA對於肌紅蛋白的辨識能力極高，為以後發展奈米人工抗體之可能，本研究利用噴霧流化床法來製備肌紅蛋白分子模版，目前顆粒大小大約500-1500 nm左右，經由酵素連結免疫吸附分析法(ELISA)測得模版上的冷光值為6.828 a.u.證實確實噴霧聚合過程對於肌紅蛋白傷害力小。並且計算模版的效能模印係數(α)達5.62。
本研究不但成功製備出高升溫能力之四氧化三鐵核心，並且結合噴霧流體化床法製備對於肌紅蛋白具親和力之磁性奈米核殼顆粒分子模版。

In several years, the cancer is the top ten of cause of death. Many studies in the biotechnology were focused on the development of the new technique to cure the cancers. In our laboratory, we integrate magnetic nanoparticles, molecular template and spray-fluidized bed technology to create a new chemical engineering technique and hope that we can work through it.
Magnetic particles have generated a lot of interests in the biomedical applications, like MRI contrast enhancement, magnetic separation, drug delivery, and hyperthermia. One of the prospective applications of magnetic nanoparticles is hyperthermia treatment of cancer. By the action of AC magnetic field, the magnetic particles generate heat through hysteresis losses. In clinical hyperthermia, efforts are made to optimize the thermal homogeneity at 42-46℃ in the tumor tissue by advanced therapy and thermometry. In this study, we successfully obtain magnetite with high heating effect through hydrothermal method. In 15 minutes, our product can get 70℃ which is much higher than the commercial product Resovist (Model Resovist, Schering AG, Germany) in the same concentration. Resovist is the contrast and is the only one product that can be injected into the human body.
Molecular imprinting is one of the promising techniques for giving a predetermined molecular recognition property onto synthetic materials such as polymers. For our laboratory, previous studies show that Methyl methacrylate (MMA) and Tetraethylene glycol methacrylate (TEGDMA) have high affinity. In this study, we use this formula combined the spray-fluidized bed successfully to prepare myoglobin molecularly imprinted polymer. The imprinting factor(α) is 5.68 which shows that the spherical particle MIP has affinity towards myoglobin.

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