| 研究生: |
王于彰 Wang, Yu-Zhang |
|---|---|
| 論文名稱: |
Smad4蛋白之表現與分子對接之研究 Expression of Smad4 protein and its molecular docking research |
| 指導教授: |
蕭世裕
Shaw, Shyh-Yu |
| 學位類別: |
碩士 Master |
| 系所名稱: |
理學院 - 化學系 Department of Chemistry |
| 論文出版年: | 2024 |
| 畢業學年度: | 112 |
| 語文別: | 中文 |
| 論文頁數: | 49 |
| 中文關鍵詞: | Smad4蛋白 、基質金屬蛋白酶 、Smad pathway 、轉化生長因子-β |
| 外文關鍵詞: | Matrix metalloproteinase-9, Smad pathway, Smad4, TGF-β |
| 相關次數: | 點閱:51 下載:0 |
| 分享至: |
| 查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
林志強, 四環黴素抑制口腔鱗狀癌細胞內基質金屬蛋白酶-9表現量之抑制機制的研究,碩士論文。國立成功大學生物科技研究所碩士班。2013。
陳宥維。Smad4 MH2蛋白質晶體結構解析度優化及與四環黴素類似物之分子對接研究,碩士論文。國立成功大學化學系碩士班。2023。
張文馨。基因重組人類Smad4蛋白之表現與功能分析,碩士論文。國立成功大學化學系碩士班。2015。
劉蒼維,et al. 骨形態發生蛋白信號通路在牙根發育中的作用. 華西口腔醫學雜誌, 2018,36(5);559-563.
Kohei Miyazono, transforming growth factor-b signaling in epithelial-mesenchymal transition and progression of cancer. Proceedings of the Japan Academy,Series B,2009.85
Bernhard Schmierer & Caroline S. Hill, TGFβ–SMAD signal transduction: molecular specificity and functional flexibility, Nature Reviews Molecular Cell Biology volume 8, pages970–982 (2007)
Jeff Yat-Fai Chung,et al, TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment, Int. J. Mol. Sci. 2021, 22(14), 7575;
Kalliopi Tzavlaki&Aristidis Moustakas, TGF-β Signaling, Biomolecules. 2020 Mar; 10(3): 487.
Niina Reunanen and VeliMatti Kähäri., Matrix Metalloproteinases in Cancer Cell Invasion, Landes Bioscience; 2000-2013.
Aki Hanyu,Yasuhiro Ishidou,et al, The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling, J Cell Biol (2001) 155 (6): 1017–1028.
Maria J. Macias,et al, Structural determinants of Smad function in TGF-β signaling,Trend in biochemical science, June 2015, Pages 296-308
Bin Qin,et al, Crystal structure of a transcriptionally active Smad4 fragment,Structure, January 1999, Pages 1493-1503
Ying Gu,et al, Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine,Journal of Microbiology, 4(1)
Trudy H. Grossman, Tetracycline Antibiotics and Resistance,Cold Spring Harbor Perspectives in Medicine, March 17, 2016
N.S. Ramamurthy,et al, The effect of alloxan diabetes on gingival collagen metabolism in rats, Archives of Oral Biology, November 1972, Pages 1551-1560
McPherson, A. & Gavira, J. A. (2014). Introduction to protein crystallization. Acta Cryst.F70,2-20
Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, Martinez-Avila N, Martinez-Fierro ML. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739.
Page-McCaw, A., Ewald, A. & Werb, Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8, 221–233 (2007).
Laronha H, Caldeira J. Structure and Function of Human Matrix Metalloproteinases. Cells. 2020 Apr 26;9(5):1076.
GROSS J, LAPIERE CM. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci U S A. 1962 Jun 15;48(6):1014-22.
Van Lint P, Libert C. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. . Biol.December 2007, 82 (6): 1375–81
T. Vartio, A. Vaheri. 1981. A gelatin-binding 70,000-dalton glycoprotein synthesized distinctly from fibronectin by normal and malignant adherent cells. J. Biol. Chem. 256: 13085–13090.
M.S. Hibbs, K.A. Hasty, J.M. Seyer, A.H. Kang, et al. 1985. Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase. J. Biol. Chem. 260: 2493–2500.
L.P. Kotra, L. Zhang, R. Fridman, R. Orlando, et al. 2002. Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9. Bioorg. Chem. 30: 356–370.
Robinson PN, Arteaga-Solis E, Baldock C, et al The molecular genetics of Marfan syndrome and related disorders Journal of Medical Genetics 2006;43:769-787.
Jennifer P. Habashi et al.Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome.Science312,117-121(2006).
Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N. Engl. J. Med. May 2000, 342 (18): 1350–8
Massague J. Receptors for the TGF-beta family. Cell. 1992 Jun 26;69(7):1067-70
Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y (March 2010). "Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells"
De Caestecker, Mark P. (2000). "The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain". The Journal of Biological Chemistry. 275 (3): 2115–2122.31.
Baburajendran, Nithya; Jauch, Ralf; Tan, Clara Yueh Zhen; Narasimhan, Kamesh; Kolatkar, Prasanna R. (2011). "Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers". Nucleic Acids Research. 39 (18): 8213–8222.
Kumar R, Kumar R, Tanwar P. Structural based screening of potential inhibitors of SMAD4: a step towards personalized medicine for gall bladder and other associated cancers. Mol Divers. 2021 Aug;25(3):1945-1961.
校內:2025-07-06公開