本研究以碳酸二甲酯(Dimethyl Carbonate，DMC)和脂環族雙醇1,4-二甲醇環己烷(1,4-Cyclohexanedimethanol，1,4-CHDM)直接合成脂肪族聚碳酸酯。在DMC/1,4-CHDM=1.8、3、5、10比例下，分別得到不同分子量的聚碳酸酯。其中，當DMC/1,4-CHDM=1.8~5時，隨著DMC過量比的提高，對於分子量的提升有明顯的幫助；當DMC/1,4-CHDM=5時，可以得到最高之分子量約為28000 Da；再進一步將過量比由5倍提升至10倍時，分子量並未見任何提升。顯見DMC之過量雖然對於反應性有幫助，但是當過量比大於5倍以後，其影響變小。經由水解試驗證實，聚碳酸酯基團的導入聚草酸酯時，對於聚草酸酯耐水解能力及材料安定性有著非常明顯的改善。當聚碳酸酯添入比例為50%時，其分子量衰減一半的時間由純草酸的10天提升至2個月。同時，由細胞實驗的觀察，也發現PCOX系列高分子擁有非常好的生物相容性，對於作為生物性材料有著極大的潛力。

In our study, we synthesized aliphatic polycarbonate directly from dimethyl carbonate (DMC) and 1,4-Cyclohexanedimethanol (1,4-CHDM). We’ve tried and found that when the ratio of DMC and 1,4-CHDM was different, the molecular weight of that batch changed. When DMC/1,4-CHDM is from 1.8 to 5, we found that the molecular weight improved as the ratio increased. Right as the ratio is 5, we got the highest molecular weight we’ve got (28000 Da). However, as we further increased the ratio to 10, the molecular weight we got was still 28000 Da without any progress. Finally we concluded that excess of DMC do help improve the reactivity of our system, but only when it’s not higher than 5.
Besides, in order to improve the stability and anti-hydrolysis ability of poly(oxalate)s, we synthesized a series of (Poly(carbonate-co-oxalate)s, PCOX). And the hydrolysis test showed that polycarbonate helps a lot.
Compared with polyoxalate, the 50% Mw loss time of Poly(carbonate50%-co-oxalate50%) was 2 months, and the 50% Mw loss time of polyoxalate was less than 10 days. At the same time, Poly(carbonate-co-oxalate)s showed its good biocompatibility in the cytoxiticity test, which indicated the great potential of being Biomaterials.

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