| 研究生: |
張瑞斌 Chang, Ruey-Bin |
|---|---|
| 論文名稱: |
微電鍍技術及其在生物晶片之應用 Micro-electroplating Technologies and Their Applications on Bio Chips |
| 指導教授: |
李國賓
Lee, Gwo-Bin |
| 學位類別: |
碩士 Master |
| 系所名稱: |
工學院 - 工程科學系 Department of Engineering Science |
| 論文出版年: | 2002 |
| 畢業學年度: | 90 |
| 語文別: | 中文 |
| 論文頁數: | 97 |
| 中文關鍵詞: | 生醫晶片 、壓模 、射出 、微電鍍 、厚膜光阻 |
| 外文關鍵詞: | bio-chip, embossing, injection, electroplating, SU-8 |
| 相關次數: | 點閱:75 下載:6 |
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本研究建立微電鍍製程技術,並利用此技術設計及製作以玻璃與塑膠(PMMA)為基材的十字型電泳晶片及微流體計數器晶片。而且發展出種微流體元件,其製程如下所述:
(1)微熱壓成型塑膠晶片:
本研究利用微電鍍鎳的技術,在S50C鋼材上鍍出十字型電泳晶片的圖形,並利用微熱壓成型技術將電鍍的圖型轉移至PMMA材質上,製作高深寬比的微流體晶片。
(2)射出成形塑膠晶片:
本研究也是利用微電鍍鎳的技術,在射出模具上鍍出十字型晶片的圖案,利用射出成形機,進行PMMA的射出,將模具上的圖案轉移至射出的PMMA塑膠上。
(3)微流體計數晶片:
此晶片利用SU-8-50負光阻作微流體計數器的結構層,在玻璃晶片上電鍍銅電極當作流體計數器的偵測電極,用來偵測微粒子在流體中的流速及大小。
(4)無電極電鍍銅噴嘴:
本研究在改善傳統微噴霧器的噴嘴,利用無電鍍鍍的方式,在毛細管的表面鍍上一層導電的銅金層,用來做微噴灑的加電壓噴嘴。
本研究發展一簡易且可靠的微電鍍製程,可製作出各式微流體元件。元件中應用微電鎳技術熱壓及射出成形的塑膠微管道結構,及用來作微流體偵測的電極,微噴灑噴嘴的無電鍍銅等技術,可以應用於化學分析方面。
In this study, critical micro-electroplating techniques to manufacture micro-capillary electrophoresis (CE) chips and microfluidic devices on glass and polymethymethacrylate (PMMA) substrates have been demonstrated. Four microfluidic devices are developed and described as follows.
(1) CE chips using hot-embossing methods
Templates with inverse images of CE channels are fabricated using micro-electroplating techniques. The images of microstructures are then transferred from templates to plastic plates by using hot embossing methods Microfluidic chips with a high aspect ratio can be achieved.
(2) CE chips using injection molding methods
Micro injection molding methods are used to duplicate micro CE chips.
(3)Micro flow cytometer chips:
SU-8-50 negative photo resist is used as structures of the micro flow cytometer for cell counting and sorting. A pair of electroplated copper electrodes is used to detect signals caused by cells.
(4)Hollow spray nozzles
A silica-based capillary is coated with a layer of copper by using electroless plating methods. Then core material is etched to form a hollow metal nozzle for electrospray applications.
In summary, micro electroplating fabrication process is developed in this study for applications of microfluidics. Micro fluidic devices with a high aspect ratio can be duplicated using hot-embossing or injection molding methods. An innovative micro flow cytometer is demonstrated using SU-8 as microstructures and electroplated coppers as sensing electrodes.
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