癲癇是一種最常見的神經系統失調疾病之一，全球約有0.6-0.8%的人患有癲癇，其中三分之二的病人可以由藥物治療來有效的控制癲癇，而剩餘的8-10%的病人可以利用手術治療，其中25%的癲癇患者不能經由任何方式成功治療。癲癇是由大腦的不正常放電所引起，因此在臨床評估、癲癇發作偵測、及治療癲癇上，腦電圖已是極為重要的工具。因此，進行癲癇腦部刺激是近年被提出的創新與有效的替代方案。目前有兩間公司NeuroPace的RNS與Medtronic的the Intercept™ Epilepsy Control System是以侵入式系統對腦部做深顱電刺激，並且完成美國FDA臨床實驗。
本篇論文中，我們以本研究團隊自行開發出的一套無線可攜式即時癲癇偵測與抑制系統，對老鼠進行長期電刺激抑制癲癇，在過程中，我們針對給予電刺激抑制的老鼠，以及單純植入電極不給電刺激的老鼠，紀錄與分析其生物阻抗及體重的變化，並配合組織切片圖，進行深顱電刺激對大腦影響之評估。研究結果發現，給予電刺激會對大腦組織阻抗產生變化，細胞密度增加，細胞電阻也會受到電刺激影響而有起伏。對老鼠本身日常生理生活並無影響。阻抗改變不影響電刺激抑制效果。

Epilepsy is one of the most common neurological disorders with a prevalence of 0.6–0.8% of the world’s population. Two-thirds of the patients achieve sufficient seizure control from anticonvulsive medication, and another 8–10% could benefit from respective surgery. For the remaining 25% of patients, no sufficient treatment is currently available. Epilepsy is caused by abnormal discharges in the brain, thus electroencephalogram (EEG) has been an especially valuable clinical tool for the evaluation, seizure detection, and treatment of epilepsy. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. At present, two invasive epilepsy control system developed by NeuroPace called RNS and Medtronic called the Intercept™ Epilepsy Control System had been completed U.S. FDA clinical trials.
In this study, we designed and operated a wireless and portable seizure control/monitor system with an a-month-long experiment to examine and clarify the effect of brain tissue with electrode implantation and electrical stimulation. The experiment was divided into control group and experiment group. We carefully measured impedance of the brain tissue and weight which above two groups during the whole experiment. To evaluate the effect of brain tissue with deep brain stimulation, impedance spectra and histological slice were used in this study. The results showed that, electrical stimulation changes structure of brain tissue, including impedance and neuroglial cell volume increased, it also influenced cell resistance. There is no affect to physiological of daily life. There was no correlation between impedance changes and efficiency of seizure suppression.

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