本研究利用微型化漫反射光譜系統，探討血液透析患者於治療過程中之動態光學訊號變化，並分析其與透析期間收縮壓波動之關聯。研究首先以仿人體組織假體驗證系統跨日穩定性，接著建立T1、T2與T3三時點臨床量測流程，並以嚴格品質控管篩選穩定之脈動光學訊號。臨床資料分析中，以收縮壓變異係數作為血壓波動指標，並建立由九項動態光學特徵組成之動態DRS分數。結果顯示，在通過嚴格品質控管之高品質資料中，動態DRS分數與收縮壓變異係數呈現顯著正相關，且此關聯於受測者層級抽樣分析中仍維持穩定。特徵精簡分析亦顯示，部分核心動態光學特徵仍保留與收縮壓波動相關之資訊。本研究結果顯示，微型化漫反射光譜系統具有作為血液透析期間局部組織光學變化與收縮壓波動輔助觀察工具之潛力。

This study used a miniaturized diffuse reflectance spectroscopy（DRS）system to investigate dynamic optical signal changes in hemodialysis patients during treatment and to analyze their association with intradialytic systolic blood pressure fluctuation. Tissue-mimicking phantoms were first used to verify the between-day stability of the system. A three-time-point clinical measurement protocol, including T1, T2, and T3, was then established, and strict quality control was applied to select stable pulsatile optical signals. In the clinical data analysis, the systolic blood pressure coefficient of variation（SBP_cv）was used as the blood pressure fluctuation index, and a dynamic DRS score composed of nine dynamic optical features was constructed. The results showed that, in high-quality data passing strict quality control, the dynamic DRS score was significantly positively correlated with SBP_cv, and this association remained stable in subject-level resampling analysis. Feature reduction analysis further showed that several core dynamic optical features still retained information related to systolic blood pressure fluctuation. These findings suggest that the miniaturized DRS system has potential as a noninvasive auxiliary tool for observing the association between local tissue optical changes and systolic blood pressure fluctuation during hemodialysis.

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