近年來，紙基微流體裝置(µPAD)得到相當多關注，因為其簡單、可攜帶以及可拋棄的特性，可用於低成本的化學、生物及環境檢測。再者，因為樣本與試劑不須使用機械或電子設備，單純以毛細現象即可進行輸送，降低了許多設備成本，而使其更容易作為檢測的裝置。目前已有各種不同製作紙基微流體裝置的方法問世，例如噴墨印刷法(ink jet printing)、紙張切割法(craft cutting)，以及光微影法(photolithography)等。本研究將呈現如何以一步驟熱微壓印製備紙基微流體裝置，探討溫度、壓力及壓印時間等變數對於研究有何影響，並且將此微流體裝置用於重金屬離子之檢測。使用本研究方法將可在10秒以內完成紙基微流體裝置之製作。

In recent years, microfluidic paper-based analytical device (µPAD) has been receiving attention because it is simple, inexpensive and power-free for low-cost chemical, biological and environmental detection. Moreover, paper is lightweight, easy to stack, store and transport, biodegradable, biocompatible, good for colorimetric tests, flammable for easy disposal of used paper-based diagnostic devices by incineration, and can be chemically modified.
Different methods have been demonstrated to fabricate µPADs such as solid wax printing, craft cutting, photolithography, etc. In this study, we proposed and demonstrated one-step hot microembossing to fabricate µPADs. The processing parameters like temperature, embossing pressure and embossing time were systematically studied. The results showed that the temperature and embossing time played important roles in fabrication of µPADs. Heavy metal detection was conducted to verify the performance of µPADs as fabricated. Fabrication of µPADs can be completed within 10 seconds.

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