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研究生: 曾正龍
Tseng, Cheng-Lung
論文名稱: 基於最大似然偵測法之多模態心跳偵測與基準點提取
Multimodal Heartbeat Detection and Fiducial Point Extraction Based on Maximum Likelihood Estimation
指導教授: 卿文龍
Chin, Wen-Long
學位類別: 碩士
Master
系所名稱: 工學院 - 工程科學系
Department of Engineering Science
論文出版年: 2017
畢業學年度: 105
語文別: 中文
論文頁數: 74
中文關鍵詞: 多模態心跳偵測基準點提取心電圖動脈血壓最大似然偵測法QRS複合波MGH/MF資料庫
外文關鍵詞: multimodal heartbeat detection, fiducial point extraction, electrocardiogram, arterial blood pressure, ML estimation, QRS complex, MGH/MF database
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  • 本篇提出在多模態記錄帶下,利用最大似然偵測法(maximum likelihood estimation, ML estimation)實現心跳偵測的演算法。此演算法使用到心電圖訊號(electrocardiogram, ECG)以及動脈血壓訊號(arterial blood pressure, ABP)來做運算。首先,將兩個訊號同時使用最大似然偵測法找出心跳的位置,再將位置的資訊結合,藉此得到更精確的偵測結果,而在ECG訊號使用ML演算法的過程中,利用其運算出的參數可標記出QRS複合波之起始點與終點的位置,使醫療單位能做更進一步的診斷與分析。
    使用MGH/MF資料庫所提供的ECG與ABP訊號及參考標籤進行模擬及驗證,在單使用ECG訊號偵測下,偵測靈敏度(Sensitivity, Se)是98.94%,預測力(Positive predictivity, P+)是98.62%,而同時使用ECG訊號以及ABP訊號偵測後,偵測靈敏度提升為98.98%,預測力提升為98.71%。使用QT資料庫所提供的基準點(fiducial point)來驗證,QRS複合波起始點及終點的平均值皆在1個sample以內,而標準差大約為3個samples。

    We present a new algorithm for the heartbeat detection based on the maximum-likelihood (ML) estimation in multimodal records. The detector uses electrocardiogram (ECG) signals and arterial blood pressure (ABP) signals. In first step, heartbeats are detected separately in both of the ECG and ABP signals. Then, the detected heartbeat positions from ECG and ABP signals are combined into a stream of detected heartbeat positions. Meanwhile, fiducial points are extracted in the process of heartbeat detection only using ECG signal. The algorithm was evaluated on several database, such as MIT-BIH Arrhythmia, MGH/MF and QT database. For the MGH/MF database, the multimodal heartbeat detector obtained a sensitivity of =98.98% and a positive predictivity of = 98.71%. As for the fiducial points of the QRS waves, the mean and standard deviation of the differences between the automatic and manual annotations were assessed. The mean error did not exceed one sample, while the standard deviations were about three samples.

    中文摘要 i 英文摘要 ii 誌謝 viii 目錄 ix 表目錄 xii 圖目錄 xiv 符號說明 xvi 第一章 緒論 1 1.1 前言 1 1.2 研究動機與目的 2 1.3 文獻探討 3 1.3.1 心跳偵測 3 1.3.2 基準點提取 7 1.4 研究貢獻 9 1.5 論文架構 9 第二章 心電圖與MIT-BIH心電資料庫 10 2.1 心電圖介紹 10 2.1.1 心電圖原理 10 2.1.2 心電圖波形 13 2.1.3 心電圖的雜訊 16 2.2 動脈血壓訊號(Arterial Blood Pressure, ABP) 17 2.3 生理訊號資料庫 19 2.3.1 MIT-BIH心律不整資料庫(Arrhythmia Database) 22 2.3.2 QT資料庫 24 2.3.3 MGH/MF資料庫 25 第三章 QRS複合波偵測演算法 26 3.1演算法架構 26 3.2訊號模型 27 3.3訊號前處理(Signal Preprocessing) 31 3.4能量偵測器(Energy Detector, ED) 33 3.5自相關器(Autocorrelator) 34 3.6最大似然偵測法(Maximum Likelihood Estimation) 36 3.7偵測步驟流程 41 第四章 多模態心跳偵測演算法 42 4.1演算法架構 42 4.2訊號模型 43 4.3訊號前處理(Signal Preprocessing) 46 4.4能量偵測器(Energy Detector, ED) 47 4.5自相關器(Autocorrelator) 47 4.6最大似然偵測法(Maximum Likelihood Estimation) 47 4.7結合心跳位置資訊 49 4.7.1 ABP訊號穩定 50 第五章 軟體模擬與驗證 51 第六章 結論與未來展望 67 參考文獻 70

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