| 研究生: |
馬國豪 Ma, Guo-Hao |
|---|---|
| 論文名稱: |
烏藥根部之成分研究 Studies on the root constituents of Lindera aggregata |
| 指導教授: |
吳天賞
Wu, Tian-Shung |
| 學位類別: |
碩士 Master |
| 系所名稱: |
理學院 - 化學系 Department of Chemistry |
| 論文出版年: | 2012 |
| 畢業學年度: | 100 |
| 語文別: | 中文 |
| 論文頁數: | 173 |
| 中文關鍵詞: | 烏藥 |
| 外文關鍵詞: | Lindera aggregata |
| 相關次數: | 點閱:122 下載:0 |
| 分享至: |
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自烏藥(Lindera aggregata)根部共分離出41個化合物,其中39個化合物經光譜分析及文獻比對後確認出其結構,分別為(+)-boldine (1)、(+)-norboldine (2)、(+)-N-methyllaurotetanine (3)、(+)-isoboldine (4)、(-)-pallidine (5)、northalifoline (6)、
N-trans-feruloyltyramine (7)、N-cis-feruloyltyramine (8)、hydroxylindestrenolide (9)、methylparaben (10)、p-hydroxybenzoic acid (11)、vanillic acid (12)、2,6-dimethoxy-p-quinone (13)、N-trans-feruloylmethoxytyramine (14)、thalifoline (15)、yuzirine (16)、linderaggrine-A (17)、linderaggredin-A (18)、linderaggredin-B (19)、linderaggredin-C (20)、linderaggredin-D (21)、linderaggredin-E (22)、rel-(2α,3β)- 7-O-methylcedrusin (23)、(-)-lyoniresinol (24)、4-hydroxy-3-methoxy acetophenone (25)、tyrosol (26)、2-(4-hydroxy-3-methoxyphenyl)ethanol (27)、
2-(4-hydroxy-3,5-dimethoxyphenyl)ethanol (28)、
3-hydroxy-1-(4-hydroxyphenyl)propan-1-one (29)、methyl 4-hydroxy-3,5-dimethoxybenzoate (30)、evofolin-B (31)、(-)-boscialin (32)、methyl dihydrophaseate (33)、6’-O-vanilloyltachioside (34)、linderaggredin-F (35)、linderaggredin-G (36)、linderagatin-A (37)、linderagatin-B (38)及2,7-dihydroxy-3,6-dimethoxyphenanthrene (39)。其中linderaggrine-A (17)、linderaggredin-A (18)、linderaggredin-B (19)、linderaggredin-C (20)、linderaggredin-D (21)、linderaggredin-E (22)為首次發現之新化合物,而linderaggredin-F (35)、linderaggredin-G (36)、linderagatin-A (37)、linderagatin-B (38)則為天然界首次分離得到新骨架之新化合物。該等化合物之生物活性正進行中。
Forty-one compounds were isolated from the roots of Lindera aggregata. Among them, thirty-nine compounds have been identified by spectral analysis methods, including (+)-boldine (1) , (+)-norboldine (2) , (+)-N-methyllaurotetanine (3) , (+)-isoboldine (4), (-)-pallidine (5) , northalifoline (6) , N-trans-feruloyltyramine (7) , N-cis-feruloyltyramine (8) , hydroxylindestrenolide (9) , methylparaben (10) , p-hydroxybenzoic acid (11) , vanillic acid (12) , 2,6-dimethoxy-p-quinone (13) , N-trans-feruloylmethoxytyramine (14) , thalifoline (15) , yuzirine (16) , linderaggrine-A (17) , linderaggredin-A (18) , linderaggredin-B (19) , linderaggredin-C (20) , linderaggredin-D (21) , linderaggredin-E (22) , rel-(2α,3β)-7-O-methylcedrusin (23) , (-)-lyoniresinol (24) , 4-hydroxy-3-methoxy acetophenone (25) , tyrosol (26) , 2-(4-hydroxy-3-methoxyphenyl)ethanol (27) ,
2-(4-hydroxy-3,5-dimethoxyphenyl)ethanol (28) ,
3-hydroxy-1-(4-hydroxyphenyl)propan-1-one (29) , methyl 4-hydroxy-3,5-dimethoxybenzoate (30) , evofolin-B (31) , (-)-boscialin (32), methyl dihydrophaseate (33) , 6’-O-vanilloyltachioside (34) , linderaggredin-F (35) , linderaggredin-G (36), linderagatin-A (37), linderagatin-B (38) and 2,7-dihydroxy-3,6-dimethoxyphenanthrene (39). Among them , linderaggrine-A (17) , linderaggredin-A (18) , linderaggredin-B (19) , linderaggredin-C (20) , linderaggredin-D (21) and linderaggredin-E (22) are new compounds, and linderaggredin-F (35) , linderaggredin-G (36) , linderagatin-A (37) , linderagatin-B (38) are reported for the first time from the natural sources as novel skeleton. The bioactivity of these isolated compounds are under progress.
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