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研究生: 馬國豪
Ma, Guo-Hao
論文名稱: 烏藥根部之成分研究
Studies on the root constituents of Lindera aggregata
指導教授: 吳天賞
Wu, Tian-Shung
學位類別: 碩士
Master
系所名稱: 理學院 - 化學系
Department of Chemistry
論文出版年: 2012
畢業學年度: 100
語文別: 中文
論文頁數: 173
中文關鍵詞: 烏藥
外文關鍵詞: Lindera aggregata
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  • 自烏藥(Lindera aggregata)根部共分離出41個化合物,其中39個化合物經光譜分析及文獻比對後確認出其結構,分別為(+)-boldine (1)、(+)-norboldine (2)、(+)-N-methyllaurotetanine (3)、(+)-isoboldine (4)、(-)-pallidine (5)、northalifoline (6)、
    N-trans-feruloyltyramine (7)、N-cis-feruloyltyramine (8)、hydroxylindestrenolide (9)、methylparaben (10)、p-hydroxybenzoic acid (11)、vanillic acid (12)、2,6-dimethoxy-p-quinone (13)、N-trans-feruloylmethoxytyramine (14)、thalifoline (15)、yuzirine (16)、linderaggrine-A (17)、linderaggredin-A (18)、linderaggredin-B (19)、linderaggredin-C (20)、linderaggredin-D (21)、linderaggredin-E (22)、rel-(2α,3β)- 7-O-methylcedrusin (23)、(-)-lyoniresinol (24)、4-hydroxy-3-methoxy acetophenone (25)、tyrosol (26)、2-(4-hydroxy-3-methoxyphenyl)ethanol (27)、
    2-(4-hydroxy-3,5-dimethoxyphenyl)ethanol (28)、
    3-hydroxy-1-(4-hydroxyphenyl)propan-1-one (29)、methyl 4-hydroxy-3,5-dimethoxybenzoate (30)、evofolin-B (31)、(-)-boscialin (32)、methyl dihydrophaseate (33)、6’-O-vanilloyltachioside (34)、linderaggredin-F (35)、linderaggredin-G (36)、linderagatin-A (37)、linderagatin-B (38)及2,7-dihydroxy-3,6-dimethoxyphenanthrene (39)。其中linderaggrine-A (17)、linderaggredin-A (18)、linderaggredin-B (19)、linderaggredin-C (20)、linderaggredin-D (21)、linderaggredin-E (22)為首次發現之新化合物,而linderaggredin-F (35)、linderaggredin-G (36)、linderagatin-A (37)、linderagatin-B (38)則為天然界首次分離得到新骨架之新化合物。該等化合物之生物活性正進行中。

    Forty-one compounds were isolated from the roots of Lindera aggregata. Among them, thirty-nine compounds have been identified by spectral analysis methods, including (+)-boldine (1) , (+)-norboldine (2) , (+)-N-methyllaurotetanine (3) , (+)-isoboldine (4), (-)-pallidine (5) , northalifoline (6) , N-trans-feruloyltyramine (7) , N-cis-feruloyltyramine (8) , hydroxylindestrenolide (9) , methylparaben (10) , p-hydroxybenzoic acid (11) , vanillic acid (12) , 2,6-dimethoxy-p-quinone (13) , N-trans-feruloylmethoxytyramine (14) , thalifoline (15) , yuzirine (16) , linderaggrine-A (17) , linderaggredin-A (18) , linderaggredin-B (19) , linderaggredin-C (20) , linderaggredin-D (21) , linderaggredin-E (22) , rel-(2α,3β)-7-O-methylcedrusin (23) , (-)-lyoniresinol (24) , 4-hydroxy-3-methoxy acetophenone (25) , tyrosol (26) , 2-(4-hydroxy-3-methoxyphenyl)ethanol (27) ,
    2-(4-hydroxy-3,5-dimethoxyphenyl)ethanol (28) ,
    3-hydroxy-1-(4-hydroxyphenyl)propan-1-one (29) , methyl 4-hydroxy-3,5-dimethoxybenzoate (30) , evofolin-B (31) , (-)-boscialin (32), methyl dihydrophaseate (33) , 6’-O-vanilloyltachioside (34) , linderaggredin-F (35) , linderaggredin-G (36), linderagatin-A (37), linderagatin-B (38) and 2,7-dihydroxy-3,6-dimethoxyphenanthrene (39). Among them , linderaggrine-A (17) , linderaggredin-A (18) , linderaggredin-B (19) , linderaggredin-C (20) , linderaggredin-D (21) and linderaggredin-E (22) are new compounds, and linderaggredin-F (35) , linderaggredin-G (36) , linderagatin-A (37) , linderagatin-B (38) are reported for the first time from the natural sources as novel skeleton. The bioactivity of these isolated compounds are under progress.

    Abstract...Ι 中文摘要...II 誌謝...III 第一章 緒論...1 第一節 前言...1 第二節 植物型態...1 第二章 山胡椒屬植物之藥理活性研究回顧...2 第三章 山胡椒屬植物之成分研究回顧...11 第四章 烏藥成分之萃取與分離...62 第五章 化學構造之研究...70 第一節 (+)-boldine (1)之構造解析...70 第二節 hydroxylindestrenolide (9)之構造解析...74 第三節 linderaggrine-A (17)之構造解析...79 第四節 linderaggredin-A (18)之構造解析...84 第五節 linderaggredin-B (19)之構造解析...90 第六節 linderaggredin-C (20)之構造解析...96 第七節 linderaggredin-D (21)之構造解析...101 第八節 linderaggredin-E (22)之構造解析...106 第九節 linderaggredin-F (35)之構造解析...111 第十節 linderaggredin-G (36)之構造解析...116 第十一節 linderagatin-A (37)之構造解析...121 第十二節 linderagatin-B (38)之構造解析...126 第十三節 其他化合物之構造研究...131 第六章 結論...132 第七章 實驗部份...136 第一節 實驗所使用之儀器與藥品...136 第二節 植物的萃取與分離...138 第三節 光譜數據...141 參考文獻...160

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