本研究旨在了解煉銅業作業勞工血液中PCDD/F/Co-PCBs濃度分布及其與健康指標之相關性，並配合作業環境空氣中的採樣結果計算操作勞工長期暴露在此作業環境下之健康風險。本研究選取兩家煉銅廠勞工，進行血液PCDD/F/Co-PCBs濃度量測及健康指標分析。並以問卷調查基本資料、飲食、時間活動模式等暴露影響因子。研究中亦同時進行兩廠作業環境中共4點的氣固相及粒徑分布之PCDD/Fs濃度分析。結果顯示，兩廠作業環境空氣之PCDD/Fs以A一廠直式澆鑄區為最高，而以B新廠為最低，4採樣點之濃度高於一般周界濃度範圍，且固相PCDD/Fs濃度遠高於氣相，毒性當量濃度貢獻主要來自PCDFs。46名勞工血液中PCDD/F/Co-PCBs之平均毒性當量濃度為28.6 pg WHO98-TEQDF/g lipid稍高於一般居民。若將本土勞工依血液中PCDD/F/Co-PCBs濃度之中位數（29.5 pg WHO98-TEQDF/g lipid）區分為高、低濃度及外籍勞工三族群，其血液中PCDD/F/Co-PCBs濃度分別為41.0、20.9及20.4 pg WHO98-TEQDF/g lipid，高濃度族群的濃度是顯著高於低濃度族群及外籍勞工（P<0.05）。在血液中PCDD/Fs的部份，三族群在10種PCDD/Fs同族物之分布相當一致。其中PCDFs的濃度以高濃度族群最高，PCDDs則相反，同源物分析顯示在三族群以2,3,4,7,8-PCDF、2,3,7,8-TCDD為主要毒性貢獻同源物；整體而言，煉銅業勞工血液中之PCDFs同源物分佈以1,2,3,4,6,7,8-HpCDF最高，2,3,4,7,8-PeCDF次之；而一般居民則以OCDF最高，且一般居民血液中PCDFs的所佔PCDD/Fs濃度比例（14.5％）遠低於煉銅廠勞工（22.5％），故可知一般居民血液中PCDD/Fs之分布確實與煉銅廠勞工不同，並且勞工血液及作業環境空氣中PCDD/Fs的分布十分相似，由此可推斷作業勞工血液中之PCDD/Fs主要來自作業環境。而在12種Co-PCBs中，三組皆以PCB118為最高，同時根據環保署的調查指出，煉銅作業環境空氣中Co-PCB的同源物分布是以PCB77、PCB169及PCB126為最高，顯示三組勞工血液中的Co-PCB應該是來自於飲食。在勞工健康檢測的部份，除血糖及GGT測值在高濃度族群是分別顯著高於低濃度族群及外籍勞工族群外（P<0.05），其餘健康指標於三族群無差異。迴歸分析顯示現職年資、勞工暴露指標與血液中PCDD/F/Co-PCBs濃度具相關性，因此煉銅廠資深勞工之PCDD/F/Co-PCBs暴露可能和作業環境有關。作業環境空氣中戴奧辛暴露劑量推估結果雖尚符合世界衛生組織建議之容忍值1-4 pg/kg/day，但與焚化爐附近一般民眾經由吸入暴露所得之劑量在0.01 pg WHO98-TEQDF /kg/day以下比較而言相當高，而空氣濃度對人體血液中濃度之貢獻在A一廠直式澆鑄區可高達85.3％，遠高於焚化爐附近一般民眾之1％以下。建議應加強煉銅過程逸散污染物之收集處理，強制配戴適當呼吸防護具，並定期進行勞工血中PCDD/F/Co-PCBs及健康檢查，以確保勞工之健康。

The objective of this study was to determine the concentrations of serum PCDD/F/Co-PCBs of operation workers, the concentrations of airbrone PCDD/Fs of working environment, and the relationship between serum PCDD/F/Co-PCBs levels and health index of workers in secondary copper smelting plant. The personal exposure data and time activity pattern were collected with questionnaires. And thirteen blood biochemistry examinations, immunological index and five hormones were examined. All the results were integrated to conduct the PCDD/F/Co-PCBs exposure assessment of workers. 46 blood samples and 4 air samples were collected and analyzed in this study. The highest TEQ levels of airborne PCDD/Fs was 34.8 pg WHO-TEQ/Nm3 sampled in the casting area at plant A, and lowest was in the casting area at plant B. The partitioning of gas/particle data showed the PCDD/Fs in particle phase was higher than gas phase. All workers were grouped to foreign and local workers, then local workers were grouped to high and low-level groups by the median of serum PCDD/Fs (29.5 pg WHO98-TEQDF/g lipid). The average serum PCDD/F/Co-PCBs levels in high, low-level and foreign groups were 41.0、20.9 and 20.4 pg-WHO-TEQ/g-lipid respectively. The TEQ levels of serum PCDD/F/Co-PCBs of all workers （28.6 pg WHO98-TEQDF/g lipid）was higher than that of general populations in Taiwan. Besides the abnormal rates of glucose in low-level group and GGT in foreign group were marginally significant lower than the high-level group, there were no significant differences of blood biochemistry, hormone, and immunological index among three groups. The dominating homologue of PCDD/Fs in blood and air samples are both PeCDFs and HxCDFs, it meant that the workers were potentially exposure to higher levels of PCDD/Fs emitted from secondary copper plant. The major congeners of Co-PCBs were PCB77, PCB169 and PCB126. The regression data showed serum PCDD/F/Co-PCBs were highly correlated with seniority and the exposure indices .The lifetime average daily does （LADD） of workers were met the range of WHO daily tolerance dose. The usage of personal protective measures was suggested to effectively reduce the exposure of PCDD/F/Co-PCBs.

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