人類疾病的研究，動物模型提供了不可缺的模擬臨床情景作探討。有效的動物模型是研究發展的基石，亦是探索重要現象的寶貴工具。而動物模型的經濟成本更與研究專案的經營息息相關。缺血性中風動物模型繁多，不單止缺血性中風疾病對社會耗費不輩，更因為它有相對高的盛行率。故缺血性中風在工業國家是一重要疾病亦是研究的重點所在。所以發展一經濟有效的缺血性中風動物模型是非常重要的。自製尼龍繩梗塞中腦動脈誘導缺血性中風是其中常用的缺血性中風動物模型。基於豐富的側枝循環，中風誘導結果並不穏定且需要相對增加樣本數以克服更大的變異差距。改善方式可以尼龍繩外包裹矽層以穏定誘發中風效果，且為商業販售。我們推論此改善誘發中風效能歸因於尼龍繩外矽層有效堵塞側枝循環。而假設此效能可以更經濟，簡單的自製尼龍繩包嵌於塑膠管中達到。我們以體感覺誘發電位，近紅外光光譜儀，測試不同的尼龍繩誘發缺血性中風模式以關連其誘發中風泛圍，以驗證自製尼龍繩-管組能以更經濟，有效誘發中風的假說.

To study the interaction of disease in human being, animal models are commonly used to mimic the essential clinical situation. A valid animal model is a fundamental element to develop an extensive research and to explore meaningful phenomenon. The cost effectiveness of the model may also be the factor for the development of a good research work. There are lots of animal models mimicking ischemic stroke conditions because it is not only costly but also has relatively high incidence in industrialized country. Homemade blunt tip nylon filament occlude the middle cerebral artery induce infarction is one of the common used ischemic stroke animal models. However, due to rich collateral blood supple nearby, the infarction induced is not consistent and requires relatively large sample size to overcome the great variation. Improvement has been made to have a silicon coating on the commercially available nylon filament. We reason that the effectiveness of the infarction size induced by commercial filament by means of reduction of leakage during occlusion. This effectiveness may reproduce easily and less costly in homemade nylon filament embedded in a plastic tube. We verified this hypothesis by comparing the measurements of near infrared spectroscopy and somatosensory evoked potentials to correlate the infarction size in different filament-induced ischemia methods. Our current result of infarction induced by filament-tube complex gave a promising result. In conclusion, we had developed an economic and effective apparatus for inducing ischemic stroke in rat model.

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