COVID-19 的全球大流行暴露了現有市售口罩在抗菌和抗病毒性能上的局限性。這些口罩主要依靠物理過濾微生物氣膠，缺乏主動滅活病原體的能力。此外，其過濾效率高度依賴靜電荷的作用，而靜電荷隨時間消散，導致防護效果顯著下降。因此，需開發具有主動消毒能力的創新口罩，以應對疫情和其他公共衛生挑戰。
氧化鋅是一種常見的抗菌材料，具備優異的光催化性能。然而，其單一成分在應用中的抗菌效力和穩定性有限。本研究針對此問題，將氧化鋅與奈米金結合，製備出具有高效抗菌性能的複合材料，並將其應用於醫療口罩表面。我們首先改良了氧化鋅與奈米金的比例，進行材料合成與特性分析，並測試了該複合材料的抗菌活性和穩定性。實驗採用SARS-CoV-2 病毒替代品噬菌體 MS2 進行測試，評估其病毒滅活效果。
研究結果顯示，經改良的氧化鋅複合奈米金材料在光催化條件下可生成活性氧物質（ROS），有效滅活附著在口罩表面的病毒。將該材料應用於口罩後，顯著提升了該口罩的病毒過濾效率。這一創新設計為提高口罩的抗菌性能提供了一種可行的解決方案，可實現更高效的個人防護，滿足在疫情和其他公共衛生危機中的需求。

The global pandemic of COVID-19 has exposed the limitations of commercially available masks in terms of antibacterial and antiviral performance. These masks primarily rely on physical filtration of microbial aerosols and lack active pathogen-inactivation capabilities. Additionally, their filtration efficiency heavily depends on electrostatic charges, which dissipate over time, leading to a significant reduction in protective efficacy. Consequently, there is an urgent need to develop innovative masks with active disinfection capabilities to address pandemics and other public health challenges.
Zinc oxide (ZnO) is a common antibacterial material with excellent photocatalytic properties. However, its single-component structure has limited antimicrobial efficacy and stability in practical applications. To address this issue, this study combined ZnO with gold nanoparticles (AuNPs) to create a composite material with enhanced antimicrobial properties, which was applied to the surface of medical masks. We first optimized the ratio of ZnO to AuNPs, synthesized the composite material, analyzed its characteristics, and tested its antimicrobial activity and stability. Experiments utilized the MS2 bacteriophage, a surrogate for SARS-CoV-2, to evaluate viral inactivation efficacy.
Results demonstrated that the optimized ZnO-AuNP composite generates reactive oxygen species (ROS) under photocatalytic conditions, effectively inactivating viruses adhering to the mask surface. When applied to masks, this material significantly enhanced viral filtration efficiency. This innovative design provides a feasible solution for improving the antibacterial performance of masks, enabling more efficient personal protection to meet demands during pandemics and other public health crises.

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