戴奧辛/呋喃已被證實為具有致癌性及致突變性之化合物，亦被稱為20世紀之世紀之毒。本研究主要目的為研究戴奧辛於台灣本土養殖魚體之累積現象，及其與環境介質間之關係外，並進一步探討台灣民眾整體的戴奧辛攝入狀態。
本研究分為兩個部份：一、研究石斑養殖場之環境介質 (水體、底泥及飼料) 中戴奧辛/呋喃及共平面多氯聯苯之濃度、魚體成長過程中之戴奧辛/呋喃及共平面多氯聯苯濃度變化、以及其在魚體裡面的累積現象。為觀察戴奧辛/呋喃及共平面多氯聯苯之累積，本研究分析石斑魚之魚苗、兩個月、十五個月、兩年以及三年之魚體中戴奧辛/呋喃及共平面多氯聯苯之濃度，並在每次魚體採樣時同步進行其他環境介質的採樣。二、分析25種台灣地區主要食物中之戴奧辛/呋喃，並研究不同年齡層及不同性別之台灣居民平均攝入之戴奧辛/呋喃總量差異，以衡量其攝食行為之安全性；此外並探討特殊族群(鴨農)對於特定食品(鴨蛋)之高攝取量行為對人體戴奧辛/呋喃攝取量所造成之影響。
第一部分研究結果顯示: 養殖池之水體、底泥之戴奧辛/呋喃及共平面多氯聯苯之濃度皆較天然水體(如河川、湖泊)濃度低，因養殖池在每次收成後皆會將養殖水體完全排乾並重新清理池底之污泥，故戴奧辛/呋喃及多氯聯苯於養殖池底泥中之累積並不如天然水體有長期累積的現象。另外養殖池環境介質中戴奧辛/呋喃濃度皆高於共平面多氯聯苯濃度，而飼料與魚體則呈現相反的趨勢，在飼料與魚體中，共平面多氯聯苯濃度皆遠高於戴奧辛/呋喃濃度，且戴奧辛/呋喃及共平面多氯聯苯在魚體中皆隨著年紀而增加，因此可以斷定飼料為魚體內含有共平面多氯聯苯之主要來源。
第二部份結果顯示，所有食物樣品中，帶殼的海鮮類以及海魚體內之戴奧辛/呋喃為最高，分別為9.82及3.60 pg WHO-TEQ/g lipid weight。台灣地區人民之戴奧辛平均攝入量最低為女性青少年(21.8 pg WHO-TEQ/day)，最高為男性老年人(37.6 pg WHO-TEQ/day)，而攝入量因飲食習慣不同而有所不同，然所有族群的平均戴奧辛/呋喃攝入量皆遠低於歐盟建議之每月攝入量的忍受值(70 pg WHO-TEQ/month)。然而有可能攝入大量受汙染鴨蛋之鴨農，當其攝取濃度大於10 pg WHO-TEQ/g lipid weight 之鴨蛋每天超過一顆就有可能超過歐盟建議之忍受值。但對台灣地區一般居民而言，受汙染的鴨蛋造成的威脅相當小。

Polychlorinated Dibenzo-p-dioxins and Dibenzofurans (PCDD/Fs) are proven as carcinogenic and mutagenic compounds, and are recognized as poisons of the century. In this study, accumulation of PCDD/Fs and dioxin-like polychlorinated biphenyls (DL-PCBs) between environmental media and fish were investigated. In addition, the dietary intake of PCDD/Fs for Taiwanese was discussed.
The first part of the study includes the PCDD/F and DL-PCB levels in environmental media (water, sediment, and feed) and in farmed fish of different age. To observe the accumulation of PCDD/Fs and DL-PCBs in farmed fish, tissue samples of hatchling, 2-month, 15-month, 24-month, and 36-month-old were collected, and the samples of all the environmental media were taken right after each time fish samples were collected.
PCDD/F levels in a total of 25 food items in Taiwan and the PCDD/F intake of Taiwanese were surveyed in the second part of this study. PCDD/F intake of some special population such as duck farmer who may ingest high quantity of contaminated duck eggs were also determined.
The results of the first part showed that PCDD/F and DL-PCB levels in water and sediment from fish farm were lower than those from natural environment such as rivers and lakes. The discharge of farm water and rearrangement of farm land each time fish were harvested may result in low levels of PCDD/Fs and DL-PCBs in water and sediment samples.
In Environmental medium, PCDD/F levels were all higher than DL-PCB levels. However, DL-PCBs were found to contribute more to the TEQ than PCDD/Fs were in all the fish samples. Both PCDD/Fs and DL-PCBs concentrations rose with the period that groupers were raised. The results in this study conclude that PCDD/Fs and DL-PCBs could accumulate in fish tissues, and diet is the main source of the accumulations.
In the second part of this study, it was observed that shellfish and saltwater fish possessed the highest PCDD/Fs levels, 9.82 and 3.60 pg WHO-TEQ/g, respectively, on the lipid basis. The dietary intakes of humans at ages of 12-18, 19-64, and over 65 were determined. The estimated intake were between 21.8 (female teenagers) and 37.6 pg (male seniors) WHO-TEQ/day; the levels varied with the dietary habits. The PCDD/F intakes for all human groups are far below the tolerable limit of 70 pg WHO-TEQ/Kg b.w./month. In addition, the daily PCDD/F intake levels for duck farmers consuming average and large amounts of PCDD/F contaminated duck eggs were examined. The result shows that consuming more than one duck egg with level higher than 10 pg WHO-TEQ/g lipid of PCDD/Fs per day could lead to a PCDD/F intake level higher than the tolerable limit. However, for normal population, there is little risk to ingest intolerable amount of PCDD/Fs because of intake of contaminated duck eggs.

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