| 研究生: |
劉懿嬋 Liu, Yi-Chan |
|---|---|
| 論文名稱: |
原發性腦瘤病患認知功能與主要照顧者認知照護能力之相關 The relationship between cognitive function in patients with brain tumor and cognitive care ability of their caregivers |
| 指導教授: |
方素瓔
Fang, Su-Ying |
| 學位類別: |
碩士 Master |
| 系所名稱: |
醫學院 - 護理學系 Department of Nursing |
| 論文出版年: | 2021 |
| 畢業學年度: | 109 |
| 語文別: | 中文 |
| 論文頁數: | 74 |
| 中文關鍵詞: | 原發性腦瘤 、認知障礙 、照顧者照護能力 |
| 外文關鍵詞: | Primary brain tumor, cognitive impairment, caregiver’s care ability |
| 相關次數: | 點閱:83 下載:0 |
| 分享至: |
| 查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
研究背景:原發性腦腫瘤雖相對罕見,卻逐年增加,且因治療進步增加存活率,讓腦瘤患者的生活品質受到重視,患者有機會透過復健,改善受損的功能。原發性腦瘤病患的認知功能受損問題會影響病患的生活品質和預後,造成病患及其照顧者生活中極大的困擾,過去治療的焦點著重治療的過程或處理生理功能方面的問題,病患照顧者認知照護能力與病患認知功能影響的實證研究付之闕如。
研究目的:本研究透過問卷了解原發性腦瘤病患認知功能的現況和原發性腦腫瘤病患主要照顧者的照護能力,進一步探討原發性腦腫瘤病患主要照顧者的認知照護能力對原發性腦瘤病患認知功能的影響。
研究方法:本研究採相關性研究設計,透過橫斷式研究(Cross-sectional research),以方便取樣方式選取南部某醫學中心神經外科門診和病房病患和家屬作為研究對象,透過問卷收集包括基本資料、蒙特利爾認知評估(The Montreal Cognitive Assessment, MoCA)、照顧者能力評估表收集資料。
研究結果:研究共納入42對病患與主要照顧者,病患MoCA分數平均為23.57(±5.81),分數大於等於24分者佔66.67%;照護者照護能力分數差距大,最低為21分,最高為80分,平均為64.71;原發性腦瘤病患主要照顧者對於認知障礙在資訊收集方式、處理經驗與分享能力的部分較低;病患年齡、病患教育程度、腫瘤大小、主要照顧者照護時數、主要照顧者照顧型態與病患認知功能有關(p<.05)。分層羅輯式回歸分析結果顯示,腫瘤大於等於三公分之病患,主要照顧者認知照護能力影響病患認知功能(p=0.01)。
結論:腦瘤病患主要照顧者對腦瘤病患認知改變的識別能力不足,未來可以增進臨床上醫療人員對於主要照顧者認知功能相關資訊的提供,特別是腫瘤較大患者之主要照顧者,進而協助主要照顧者提供病患居家認知復健活動,增進患者和其主要照顧者對疾病的調適。
Primary brain tumors are relatively rare tumors, and increased gradually. Most health professionals usually focus on treatments to improve physiological function. In addition, research on cognitive care ability of caregivers and the impact to patients' cognitive function is lacking. The purpose of this study was to understand the impact of the cognitive care ability of caregivers on cognitive function of patients with primary brain tumors. We used correlation, cross-sectional and convenience sampling to investigate the status of cognitive function in primary brain tumor patients in this study. The data analyzes by chi- square test, linear regression and logistic regression. Forty-two patients and their caregivers were recruited. Caregivers have lower levels of information collection, processing experience, and lack of ability on sharing experience about patients’ cognitive impairment. Patient’s age, patient’s education, tumor size, caregiver's care hours and caregiver's type of care were related to the patient's cognitive functions. As for the patients with tumor size larger than 3cm, their caregivers’ cognitive care ability affected patients’ cognitive function. In the future, providing caregivers information about cognitive function in clinical scenarios is suggested.
內政部統計處(2018).內政統計通報.Retrieved from https://www.moi.gov.tw/files/news_file/107%e5%b9%b4%e7%ac%ac9%e9%80%b1%e5%85%a7%e6%94%bf%e7%b5%b1%e8%a8%88%e9%80%9a%e5%a0%b1_15%e6%ad%b2%e4%bb%a5%e4%b8%8a%e4%ba%ba%e5%8f%a3%e6%95%99%e8%82%b2%e7%a8%8b%e5%ba%a6.pdf
吳孟純、王亭貴、張權維(2002).腦瘤患者與中風患者復健成效之比較.中華 民國復健醫學會雜誌,30(1),19-26。
張美玉、徐莞雲、徐倩儀、林麗英(2016).新診斷癌症病人生活品質之相關因素探討.榮總護理,33(3),293-302。
張慈君、徐亞瑛、陳明岐、邱逸榛、黃惠玲(2012).失智症家庭照顧者問題處理能力預測因子之探討.護理雜誌,59(6),25-35。
黃惠玲、徐亞瑛(2003).照顧者訓練方案對改善失智症照顧者能力之探討.長期照護雜誌,7(2),121-134。
劉雅芬、黃子珍、張維琴、穆佩芬、溫美蓉(2015).建立初次診斷原發性膠質惡性腦瘤成年病人之臨床照護指引(Establishing Clinical Care Guidelines for Adult Patients Initially Diagnosed with Glioma).腫瘤護理雜誌,15(2),51-67。
劉雅菁、薄喬萍、葉淑惠、利怡慧、郭美玲、黃翠媛(2013).腦中風病人主要照顧者之照護需求及其相關因素探討.長庚護理,24(3),239-251。
衛生福利部(2015).第三期國家癌症防治計畫(103-107年).衛生福利部。
衛生福利部國民健康署(2020).癌症登記報告.衛生福利部國民健康署。
鄭玉欣、劉安祥、劉怡、陳幸眉(2016).腦瘤手術前病人的主要照顧者之照護需求及相關因素之探討.護理雜誌, 63(3),31-41。
謝佳容(2003).老年人認知功能的指標測量與應用醫護科技學刊,5(4), 387-395。
Akeret, K., Serra, C., Rafi, O., Staartjes, V. E., Fierstra, J., Bellut, D., . . . Poryazova, R. (2019). Anatomical features of primary brain tumors affect seizure risk and semiology. NeuroImage: Clinical, 22, 101688.
Archibald, B., Solomon, K., & Stephenson, G. (1994). Estimating pirimicarb exposure to greenhouse workers using video imaging. Archives of environmental contamination and toxicology, 27(1), 126-129.
Association, A. B. T. (2017). Brain Tumor Education. Retrieved from https://www.abta.org/about-brain-tumors/brain-tumor-education/#statistics
Association, A. P. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub.
Awad, A.-W., Karsy, M., Sanai, N., Spetzler, R., Zhang, Y., Xu, Y., & Mahan, M. A. (2017). Impact of removed tumor volume and location on patient outcome in glioblastoma. Journal of neuro-oncology, 135(1), 161-171.
Bergo, E., Lombardi, G., Guglieri, I., Capovilla, E., Pambuku, A., & Zagone, V. (2019). Neurocognitive functions and health-related quality of life in glioblastoma patients: a concise review of the literature. European Journal of Cancer Care, 28(1), e12410. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1111/ecc.12410. doi:https://doi.org/10.1111/ecc.12410
Bergo, E., Lombardi, G., Pambuku, A., Della Puppa, A., Bellu, L., D’Avella, D., & Zagonel, V. (2016). Cognitive rehabilitation in patients with gliomas and other brain tumors: state of the art. BioMed Research International, 2016.
Boele, F. W., Grant, R., & Sherwood, P. (2017). Challenges and support for family caregivers of glioma patients. British Journal of Neuroscience Nursing, 13(1), 8-16.
Bommakanti, K., Somayajula, S., Suvarna, A., Purohit, A. K., Mekala, S., Chadalawadi, S. K., & Gaddamanugu, P. (2016). Pre-operative and post-operative cognitive deficits in patients with supratentorial meningiomas. Clinical neurology and neurosurgery, 143, 150-158.
Boone, W., & Piccinini, G. (2016). The cognitive neuroscience revolution. Synthese, 193(5), 1509-1534.
Brauer, S. (2013). Brain injury rehabilitation. Journal of physiotherapy, 59(4), 278-278.
Bunevicius, A., Tamasauskas, S., Deltuva, V., Tamasauskas, A., Radziunas, A., & Bunevicius, R. (2014). Predictors of health-related quality of life in neurosurgical brain tumor patients: focus on patient-centered perspective. Acta neurochirurgica, 156(2), 367-374.
Carlozzi, N. E., Sherman, C. W., Angers, K., Belanger, M. P., Austin, A. M., & Ryan, K. A. (2018). Caring for an individual with mild cognitive impairment: a qualitative perspective of health-related quality of life from caregivers. Aging & mental health, 22(9), 1196-1204.
Carnevale, G. J., Anselmi, V., Busichio, K., & Millis, S. R. (2002). Changes in ratings of caregiver burden following a community-based behavior management program for persons with traumatic brain injury. The Journal of head trauma rehabilitation, 17(2), 83-95.
Cicerone, K. D., Langenbahn, D. M., Braden, C., Malec, J. F., Kalmar, K., Fraas, M., . . . Bergquist, T. (2011). Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Archives of physical medicine and rehabilitation, 92(4), 519-530.
Cohen, J. (1988). Statistical power analysis for the behavioral sciences, 2nd edn. Á/L. In: Erbaum Press, Hillsdale, NJ, USA.
Cornwell, P., Dicks, B., Fleming, J., Haines, T. P., & Olson, S. (2012). Care and support needs of patients and carers early post-discharge following treatment for non-malignant brain tumour: establishing a new reality. Supportive Care in Cancer, 20(10), 2595-2610.
Day, J., Gillespie, D. C., Rooney, A. G., Bulbeck, H. J., Zienius, K., Boele, F., & Grant, R. (2016). Neurocognitive deficits and neurocognitive rehabilitation in adult brain tumors. Current treatment options in neurology, 18(5), 22.
Diansari, Y., Harun, Y., Marisdina, S., & Felistia, Y. (2019). P05. 01 the efficacy of donepezil on cognitive function in postoperative brain tumor patients. Neuro-oncology, 21(Suppl 3), iii33.
Englot, D. J., Chang, E. F., & Vecht, C. J. (2016). Epilepsy and brain tumors. In Handbook of clinical neurology (Vol. 134, pp. 267-285): Elsevier.
Finocchiaro, C. Y., Petruzzi, A., Lamperti, E., Botturi, A., Gaviani, P., Silvani, A., . . . Salmaggi, A. (2012). The burden of brain tumor: a single-institution study on psychological patterns in caregivers. Journal of neuro-oncology, 107(1), 175-181.
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research, 12(3), 189-198.
Ganguli, M., Snitz, B. E., Lee, C.-W., Vanderbilt, J., Saxton, J. A., & Chang, C.-C. H. (2010). Age and education effects and norms on a cognitive test battery from a population-based cohort: The Monongahela–Youghiogheny Healthy Aging Team. Aging and Mental Health, 14(1), 100-107.
Gareau, M. (2016). Cognitive function and the microbiome. In International review of neurobiology (Vol. 131, pp. 227-246): Elsevier.
Gehrke, A. K., Baisley, M. C., Sonck, A. L., Wronski, S. L., & Feuerstein, M. (2013). Neurocognitive deficits following primary brain tumor treatment: systematic review of a decade of comparative studies. Journal of neuro-oncology, 115(2), 135-142.
Gorsuch, R. L. (1997). Exploratory factor analysis: Its role in item analysis. Journal of personality assessment, 68(3), 532-560.
Heckel, M., Hoser, B., & Stiel, S. (2018). Caring for patients with brain tumors compared to patients with non-brain tumors: Experiences and needs of informal caregivers in home care settings. Journal of psychosocial oncology, 36(2), 189-202.
Hendrix, P., Hans, E., Griessenauer, C. J., Simgen, A., Oertel, J., & Karbach, J. (2017). Neurocognitive status in patients with newly-diagnosed brain tumors in good neurological condition: the impact of tumor type, volume, and location. Clinical neurology and neurosurgery, 156, 55-62.
Janda, M., Steginga, S., Dunn, J., Langbecker, D., Walker, D., & Eakin, E. (2008). Unmet supportive care needs and interest in services among patients with a brain tumour and their carers. Patient education and counseling, 71(2), 251-258.
Kabuba, N., Menon, J. A., Franklin Jr, D. R., Lydersen, S., Heaton, R. K., & Hestad, K. A. (2018). Effect of age and level of education on neurocognitive impairment in HIV positive Zambian adults. Neuropsychology, 32(5), 519.
Kajiwara, K., Kako, J., Noto, H., Oosono, Y., & Kobayashi, M. (2020). The benefits of support groups for caregivers of patients with brain tumors. Supportive Care in Cancer, 28(9), 3979-3980.
Kesler, S. R., Noll, K., Cahill, D. P., Rao, G., & Wefel, J. S. (2017). The effect of IDH1 mutation on the structural connectome in malignant astrocytoma. Journal of neuro-oncology, 131(3), 565-574.
Kosberg, J. I., & Cairl, R. E. (1992). Burden and competence in caregivers of Alzheimer's disease patients: Research and practice implications. Journal of Gerontological Social Work, 18(1-2), 85-96.
Langenbahn, D. M., Ashman, T., Cantor, J., & Trott, C. (2013). An evidence-based review of cognitive rehabilitation in medical conditions affecting cognitive function. Archives of physical medicine and rehabilitation, 94(2), 271-286.
Levisohn, L., Cronin-Golomb, A., & Schmahmann, J. D. (2000). Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. Brain, 123(5), 1041-1050.
Lezak, E., Kulinski, Z., Masirek, R., Piorkowska, E., Pracella, M., & Gadzinowska, K. (2008). Mechanical and thermal properties of green polylactide composites with natural fillers. Macromolecular bioscience, 8(12), 1190-1200.
Lin, K.-N., Wang, P.-N., Liu, H.-C., & Teng, E. L. (2012). Cognitive abilities screening instrument, Chinese version 2.0 (CASI C-2.0): administration and clinical application. Acta Neurol Taiwan, 21(4), 180-189.
Liouta, E., Koutsarnakis, C., Liakos, F., & Stranjalis, G. (2016). Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study. Journal of Neurosurgery, 124(6), 1578-1584.
Liu, H.-C., Chou, P., Lin, K., Wang, S., Fuh, J., Lin, H., . . . White, L. (1994). Assessing cognitive abilities and dementia in a predominantly illiterate population of older individuals in Kinmen. Psychological medicine, 24(3), 763-770.
Locke, D. E., Cerhan, J. H., Wu, W., Malec, J. F., Clark, M. M., Rummans, T. A., & Brown, P. D. (2008). Cognitive rehabilitation and problem-solving to improve quality of life of patients with primary brain tumors: a pilot study. J Support Oncol, 6(8), 383-391.
Meskal, I., Gehring, K., Rutten, G.-J. M., & Sitskoorn, M. M. (2016). Cognitive functioning in meningioma patients: a systematic review. Journal of neuro-oncology, 128(2), 195-205.
Meyers, C. A., & Brown, P. D. (2006). Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. Journal of Clinical Oncology, 24(8), 1305-1309.
Meyers, C. A., & Hess, K. R. (2003). Multifaceted end points in brain tumor clinical trials: cognitive deterioration precedes MRI progression. Neuro-oncology, 5(2), 89-95.
Meyers, C. A., Hess, K. R., Yung, W. A., & Levin, V. A. (2000). Cognitive function as a predictor of survival in patients with recurrent malignant glioma. Journal of Clinical Oncology, 18(3), 646-646.
Mitchell, T., & Turton, P. (2011). ‘Chemobrain’: concentration and memory effects in people receiving chemotherapy–a descriptive phenomenological study. European Journal of Cancer Care, 20(4), 539-548.
Monje, M. L., Mizumatsu, S., Fike, J. R., & Palmer, T. D. (2002). Irradiation induces neural precursor-cell dysfunction. Nature medicine, 8(9), 955-962.
Monje, M. L., Vogel, H., Masek, M., Ligon, K. L., Fisher, P. G., & Palmer, T. D. (2007). Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 62(5), 515-520.
Mukand, J. A., Blackinton, D. D., Crincoli, M. G., Lee, J. J., & Santos, B. B. (2001). Incidence of neurologic deficits and rehabilitation of patients with brain tumors. American journal of physical medicine & rehabilitation, 80(5), 346-350.
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., . . . Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695-699.
Noggle, C. A., & Dean, R. S. (2013). Neuropsychology and cancer: An emerging focus.
Olson, R. A., Chhanabhai, T., & McKenzie, M. (2008). Feasibility study of the Montreal Cognitive Assessment (MoCA) in patients with brain metastases. Supportive Care in Cancer, 16(11), 1273-1278.
Ostrom, Q. T., Cioffi, G., Gittleman, H., Patil, N., Waite, K., Kruchko, C., & Barnholtz-Sloan, J. S. (2019). CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro-oncology, 21(Supplement_5), v1-v100.
Parvataneni, R., Polley, M.-Y., Freeman, T., Lamborn, K., Prados, M., Butowski, N., . . . Rabbitt, J. (2011). Identifying the needs of brain tumor patients and their caregivers. Journal of neuro-oncology, 104(3), 737-744.
Petruzzi, A., Finocchiaro, C. Y., Lamperti, E., & Salmaggi, A. (2013). Living with a brain tumor. Supportive Care in Cancer, 21(4), 1105-1111.
Pranckeviciene, A., Tamasauskas, S., Deltuva, V. P., Bunevicius, R., Tamasauskas, A., & Bunevicius, A. (2016). Suicidal ideation in patients undergoing brain tumor surgery: prevalence and risk factors. Supportive Care in Cancer, 24(7), 2963-2970.
Rahman, Z., Wong, C., Dexter, M., Olsson, G., Wong, M., Gebsky, V., . . . King, M. (2015). Epilepsy in patients with primary brain tumors: the impact on mood, cognition, and HRQOL. Epilepsy & Behavior, 48, 88-95.
Renovanz, M., Reitzug, L., Messing, L., Scheurich, A., Grüninger, S., Ringel, F., & Coburger, J. (2018). Patient reported feasibility and acceptance of Montreal cognitive assessment (MoCA) screening pre-and postoperatively in brain tumour patients. Journal of Clinical Neuroscience, 53, 79-84.
Rudà, R., Trevisan, E., & Soffietti, R. (2010). Epilepsy and brain tumors. Current opinion in oncology, 22(6), 611-620.
Sacks-Zimmerman, A., Duggal, D., & Liberta, T. (2015). Cognitive remediation therapy for brain tumor survivors with cognitive deficits. Cureus, 7(10).
Salazar, A. M., Warden, D. L., Schwab, K., Spector, J., Braverman, S., Walter, J., . . . Ecklund, J. (2000). Cognitive rehabilitation for traumatic brain injury: A randomized trial. Jama, 283(23), 3075-3081.
Schubart, J. R., Kinzie, M. B., & Farace, E. (2008). Caring for the brain tumor patient: family caregiver burden and unmet needs. Neuro-oncology, 10(1), 61-72.
Schubert, C. C., Boustani, M., Callahan, C. M., Perkins, A. J., Carney, C. P., Fox, C., . . . Hendrie, H. C. (2006). Comorbidity profile of dementia patients in primary care: are they sicker? Journal of the American Geriatrics Society, 54(1), 104-109.
Sheline, G. E., Wara, W. M., & Smith, V. (1980). Therapeutic irradiation and brain injury. International Journal of Radiation Oncology* Biology* Physics, 6(9), 1215-1228.
Smith, L. M., & Godfrey, H. P. (1995). Family support programs and rehabilitation: A cognitive-behavioral approach to traumatic brain injury: Springer Science & Business Media.
Stanca, D., Crăiţoiu, S., Zaharia, C., Tudorica, V., Albu, C., Alexandru, O., . . . Trifan, F. (2011). Prospective study on the presence of cognitive impairments in patients with brain tumors. Romanian Journal of Neurology/ Revista Romana de Neurologie, 10, 131-135. doi:10.37897/RJN.2011.3.5
Stupp, R., Brada, M., Van Den Bent, M., Tonn, J.-C., & Pentheroudakis, G. (2014). High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology, 25(suppl_3), iii93-iii101.
Stupp, R., Hegi, M. E., Mason, W. P., Van Den Bent, M. J., Taphoorn, M. J., Janzer, R. C., . . . Belanger, K. (2009). Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. The lancet oncology, 10(5), 459-466.
Stupp, R., Tonn, J.-C., Brada, M., Pentheroudakis, G., & Group, E. G. W. (2010). High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of oncology, 21(suppl_5), v190-v193.
Tang, V., Rathbone, M., Dorsay, J. P., Jiang, S., & Harvey, D. (2008). Rehabilitation in primary and metastatic brain tumours. Journal of neurology, 255(6), 820-827.
Taphoorn, M. J., & Klein, M. (2004). Cognitive deficits in adult patients with brain tumours. The Lancet Neurology, 3(3), 159-168.
Teixidor, P., Gatignol, P., Leroy, M., Masuet-Aumatell, C., Capelle, L., & Duffau, H. (2007). Assessment of verbal working memory before and after surgery for low-grade glioma. Journal of neuro-oncology, 81(3), 305-313.
Teng, E. L., Hasegawa, K., Homma, A., Imai, Y., Larson, E., Graves, A., . . . Chiu, D. (1994). The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. International psychogeriatrics, 6(1), 45-58.
Tremont‐Lukats, I. W., Ratilal, B. O., Armstrong, T., & Gilbert, M. R. (2008). Antiepileptic drugs for preventing seizures in people with brain tumors. Cochrane database of systematic reviews(2).
Tsai, C.-F., Lee, W.-J., Wang, S.-J., Shia, B.-C., Nasreddine, Z., & Fuh, J.-L. (2012). Psychometrics of the Montreal Cognitive Assessment (MoCA) and its subscales: validation of the Taiwanese version of the MoCA and an item response theory analysis. International psychogeriatrics, 24(4), 651.
Tucha, O., Smely, C., Preier, M., & Lange, K. W. (2000). Cognitive deficits before treatment among patients with brain tumors. Neurosurgery, 47(2), 324-334.
Wefel, J. S., Noll, K. R., & Scheurer, M. E. (2016). Neurocognitive functioning and genetic variation in patients with primary brain tumours. The lancet oncology, 17(3), e97-e108.
Weitzner, M. A., & Meyers, C. A. (1997). Cognitive functioning and quality of life in malignant glioma patients: a review of the literature. Psycho‐Oncology: Journal of the Psychological, Social and Behavioral Dimensions of Cancer, 6(3), 169-177.
Witte, O. W. (1988). Lesion‐induced plasticity as a potential mechanism for recovery and rehabilitative training. Current opinion in neurology, 11(6), 655-662.
Yang, Y., Rushton, S., Park, H. K., Son, H., Woodward, A., Mcconnell, E., & Hendrix, C. C. (2020). Understanding the Associations between Caregiver Characteristics and Cognitive Function of Adults with Cancer: A Scoping Review. Asia-Pacific Journal of Oncology Nursing, 7(2), 115.
Zucchella, C., Bartolo, M., Di Lorenzo, C., Villani, V., & Pace, A. (2013). Cognitive impairment in primary brain tumors outpatients: a prospective cross-sectional survey. Journal of neuro-oncology, 112(3), 455-460.
Zucchella, C., Capone, A., Codella, V., De Nunzio, A. M., Vecchione, C., Sandrini, G., . . . Bartolo, M. (2013). Cognitive rehabilitation for early post-surgery inpatients affected by primary brain tumor: a randomized, controlled trial. Journal of neuro-oncology, 114(1), 93-100.