由於癌症已蟬聯國人十大死因之首26年，因此癌症治療的研究ㄧ直都是生醫技術相當重要的方向，尤其是副作用低、溫和而有效的治療方法。而熱治療是近年來相當受重視的一種療法，本研究希望結合磁性微脂粒、核殼結構、藥物標的釋放等技術來製備出複合功能的磁性微脂粒作為熱治療的藥劑，期望能提供熱治療技術一個有益的方向。
本研究以共沉澱法製備磁性氧化鐵奈米粒子，並以十二碳酸修飾避免磁性奈米粒子的聚集。利用熱重分析儀(TGA)、傅立葉紅外光分析儀(FT-IR)、X-ray繞射儀(XRD)與超導量子干涉震動磁量儀(SQUID)分析結構與特性，以穿透式電子顯微鏡(TEM)、奈米粒徑電位分析儀 (Zeta-Sizer)分析粒徑大小，由測試結果知道修飾後氧化鐵奈米粒子粒徑較小而飽和磁化強度下降。
核殼結構磁性微脂粒的核種材料有三種： PMMA、生物相容的二氧化矽與作為藥物替代物的甲殼素(Chitosan)奈米粒子，分別進行測試，以深入討論製備影響因素。以薄膜水合法包覆磁性氧化鐵奈米粒子與核奈米粒子，成為核殼結構的磁性微脂粒。利用TEM影像分析微脂粒的包覆結果與分散性，以確認較佳製備條件。接著以高週波電感應加熱機模擬熱治療環境測試微脂粒的加熱效果，在15分鐘的測試時間內觀察樣本的最大溫度變化，測試結果發現氧化鐵含量越高，包覆情形越好的微脂粒，升溫速率越高。而以PMMA奈米粒子與二氧化矽奈米粒子做核心粒子的核殼結構磁性微脂粒有較好的包覆結果，並在15分鐘內達到大於5 (℃/4ml待測溶液)的溫度變化；以甲殼素奈米粒子做核心粒子做核殼結構磁性微脂粒，因包覆成果不好而升溫速率不佳。

Cancer has been at the head of the top ten causes of death for last two decades. Therefore, cancer therapy was always the most important thing in biotechnologic researches, especially in lowing side effect, and more effective and mild therapys. Because cancer therapy was recently focoused on hyperthermia, the aim of this research was to synthesize the magnetic liposomes with complex function by combining the technology of magnetic core-shell liposome and targeting drug delivery. This magnetic core-shell liposome would be used in hyperthermia and provided a useful way for hyperthermia technology.
In this study, magnetic ferric oxide nanoparticles were firstly synthesized by coprecipitation method, and then the surface was modified by lauric acid to prevent the aggregation of magnetic nanoparticles. The structure and properties of magnetic nanoparticles were analyzed by TGA, FT-IR, XRD, and SQUID. The particle size was analyzed by TEM and Zeta-Sizer. The results indicated that modified ferric oxide nanoparticles had lower particle size and saturation magnetization than unmodified nanoparticles.
PMMA, biocompatible silica, and chitosan were used as core materials in magnetic core-shell liposome. PMMA, and biocompatible silica, were used to study preparing condition and affecting factors of synthesis, respectively. Chitosan was used as a substitute of drug. Core nanoparticles were encapsulated with lipid film that attached magnetic ferric oxide nanoparticles by thin film hydration method. In order to obtain the better condition of synthesis, encapsulating result and dispersion of liposomes were analysized by TEM. In hyperthermia, heating efficiency of liposomes were simulate by high frequency machine. The experiment could get maximum difference of temperature in fifteen minutes. The higher amount of iron oxide nanoparticles and better encapsulation would cause higher heating rate. In the study of encapsulation, PMMA and silica nanoparticles used as core materials of magnetic core-shell liposome showed better encapsulated result. The temperature changes which PMMA and silica nanoparticles used as core of over 5℃ per 4 milliliter could be reached in fifteen minutes. Nevertheless, the magnetic core-shell liposome using chitosan as a core had bad heating efficiency because of bad encapsulation.

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