經皮冠狀動脈介入治療 (PCI) 是治療血管栓塞的主要方法，可透過於患部植入心血管支架來重建堵塞的血管。生物可降解的心血管支架材料包括純鐵 (Fe)、鎂 (Mg) 和鋅 (Zn)。在近年的研究中，由於鋅優異的生物相容性與生物降解性，具備發展為新一代心血管支架的潛力。然而，純鋅在植入血管後的局部腐蝕和鋅離子累積可能導致支架徑向力的損失和產生不利於血管修復的環境。為了有效解決這些缺點，本研究使用微波輔助化學轉化方法在純鋅上製備磷酸鋅 (ZnP) 塗層。ZnP塗層的微結構主要由磷酸鋅 (Zn3(PO4)2) 和磷酸鋅鈉 (NaZn2(PO)4) 所組成。不同比例的微觀結構可形成不同表面粗糙度與降解模式。在電化學測試與體外浸泡實驗中，磷酸鋅鈉的出現可以改善純鋅的腐蝕行為。在體外生物相容性中，ZnP 塗層具備可接受的細胞毒性和有利於細胞貼附的降解表面。在血液相容性中，ZnP 塗層表現非溶血性的結果和抑制血小板貼附的作用。總結來說，ZnP 塗層可以表現出均勻的降解行為和有助於血管重塑的生物效應，是作為鋅心血管支架塗覆層的良好材料。

Percutaneous coronary intervention (PCI) is a primary treatment for cardiovascular diseases. The materials of the bioresorbable cardiovascular stent include iron (Fe), magnesium (Mg), and zinc (Zn). Zn has been discovered as a potential material of stents due to its intrinsic physiological relevance, biocompatibility, biodegradability, and pro-regeneration properties. However, localized corrosion and burst release of zinc ions might cause an early implant failure and a harmful environment for vascular remodeling. To efficiency solving these drawbacks, a zinc phosphate (ZnP) coating was prepared with a microwave-assisted chemical conversion method on pure zinc in this study. The microstructures of ZnP groups are mainly composed of zinc phosphate (Zn3(PO4)2) and sodium zinc phosphate (NaZn2(PO)4). These compounds altered the surface roughness, and the corrosion behavior could improve by the appearance of sodium zinc phosphate. The in vitro biocompatibility of ZnP coatings shows acceptable cell viability and a stable and smoother degradation surface for cell adhesion. Furthermore, the hemocompatibility of ZnP exhibited nonhemolytic results and inhibitions to the adhesion of platelets. In conclusion, ZnP coatings could exhibit a uniform degradation behavior and a positive biological effect for vascular remodeling.

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