在臨床牙科的牙周再生手術中，常會運用牙周再生薄膜防止傷口遭受細菌或纖維母細胞侵入，同時讓營養素和血液通過，並且引導齒槽骨(alveolar bone)再生。幾丁聚醣(CS)具有無毒性、生物相容性、抗菌性等優點。聚乙烯醇(polyvinyl alcohol，PVA)具有生物降解性、高親水性、低沾黏等優點。介孔生醫玻璃(mesoporous bioactive glass)擁有生物親和性和優異的攜藥能力，可作為奈米載體運用於牙科中的藥物輸送。
本研究第一部分先將PVA混入CS基底的熱感應性水凝膠(thermosensitive hydrogel)。結果顯示，PVA添加能夠提高薄膜的韌性、生物親和性，經由降解測試證明，PVA/CS能維持薄膜特性長達8週。第二部分再藉由溶膠凝膠法將0, 1, 2, 4 wt%生醫玻璃(bioactive glass，BG)粉末加入4% PVA/CS水凝膠，形成BG/4% PVA水凝膠薄膜。研究結果顯示，BG具有介孔結構和良好的仿生(biomimetic)能力，並且成功添加入4% PVA/CS薄膜之中，提升了薄膜的吸水性，以及增加了薄膜的抗拉強度、伸長率和韌性，還有穩定的降解速率，而且不會改變薄膜的厚度和結構。
結合BG與PVA/CS基底的水凝膠可吸收性牙周再生薄膜，擁有良好的生物親和性，若將此材料應用於牙科再生手術，可防止細菌感染手術傷口，以及阻隔增生過於迅速的軟組織，同時能夠提供足夠的空間讓骨組織再生、加速傷口癒合。這種三元共聚的水凝膠薄膜在牙周再生手術中，將會是極具發展潛力的牙周再生薄膜材料，或是在臨床應用上會有極大的潛力。

In periodontal regeneration surgery, periodontal regeneration membranes are often used to prevent bacteria or fibroblasts from invading while allowing nutrients and blood to pass through. Chitosan (CS) possesses non-toxicity, biodegradation, biocompatibility, antibacterial property. Polyvinyl alcohol (PVA) offers the advantages of biodegradability, high hydrophilicity, and low adhesion. Mesoporous bioactive glass (MBG) provides proper manufacturability, biocompatibility, and drug delivery ability.
The first part of this thesis, CS thermosensitive hydrogel was blending with PVA. The results indicated that PVA could enhance the toughness, biocompatibility and keep its function after 8 weeks biodegradation. In second part, 0, 1, 2, 4 wt% of nano bioactive glass (BG) had been added into 4%PVA/CS thermosensitive hydrogel by sol-gel method. The mesoporous BG was demonstrated to be biomimetic in vitro and had been successfully added into 4%PVA/CS. The addition of BG improved the swelling ability, ultimate tensile strength, elongation and toughness while remaining the structure and stable degradation rate of the BG/4% PVA film.
In conclusion, BG combining with the CS based PVA hydrogel absorbable periodontal regeneration membrane for periodontal regeneration treatment can block the invasion of bacteria or fibroblasts to prompt wound healing and accelerating bone tissue growth. PVA/CS hydrogel will be an effective material of periodontal regeneration treatment for the field of dentistry.

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