本論文主要目的在於開發一套以外差式干涉術(heterodyne interferometry)為基礎之量測系統，輔以自行推導的計算公式來同步量測一對掌性(chiral)物質之光學旋光性(optical rotatory dispersion，ORD) 與圓二色性(circular dichroism，CD)的橢圓率資訊。藉由以此外差式干涉架構中所得的兩通道訊號間的相位差(phase difference)與振幅的比值，來同時求得出我們所要的ORD與CD資訊，也因如此，雷射相位與光強的穩定與否對所求的資訊解析度就顯得非常重要。
相位穩定問題部分，由於量測架構以兩通道訊號間的相位差為計算基準，因此，雷射本身的相位穩定較不是問題，而周邊環境因素為主要關鍵。本論文除了於對雷射經過的區域做隔離控制外，也對樣本做溫度控制，將所有熱源包含雷射造成的部分與量測系統隔絕，來加以改善其訊號穩定度。實驗中發現其相位穩定度由0.47 rad改善至0.01 rad，經計算所得到的光學旋轉角解析度約為8.3×10^-5 度，其對應的葡萄糖濃度解析能力可達到1.8×10^-5(g/ml) 。至於雷射光強的部分，實驗中在雷射出射處直接引出一道作為正規化作用，來提高雷射光強訊號的量測穩定度，用以提升其振幅訊號的訊噪比(signal-to-noise ratio，SNR)，可得之CD橢圓率解析度約為2.4×10^-4 rad。

The main purpose of this thesis is to develop a heterodyne interferometry-based detection system with in-lab developed algorithm to measure the optical rotatory dispersion (ORD) and the circular dichroism (CD) of the ellipticity information of chiral materials simultaneously. According to the phase difference and the magnitude ratio between the two channel signals of the heterodyne interferometry detection system, the ORD and CD can be obtained, respectively. Hence, the stabilities of the phase and intensity of the light source will affect the detection resolution.
Regarding the phase stability issue, the measurement framework based on the phase difference of the two-channel signals will eliminate the laser’s phase instability; hence, the measurement environment will dominate the stability of the phase measurement. To resolve the problem, the temperature of the sample is controlled and the heating sources are isolated from the detection system. The experimental results demonstrate that the phase stability is improved from 0.47 rad down to 0.01 rad in root mean square error. The corresponding detection resolution at the rotation angle of glucose solution is about 8.3×10^-5 rad and the corresponding concentration is 1.8×10^-5 (g/ml) . About the intensity stability, the measurement intensity signal is normalized with a reference beam signal to achieve the intensity signal stability better than 1 %, so the signal-to-noise ratio (SNR) of the amplitude ratio measurement is improved. Currently, the detection resolution of the CD ellipticity is about 2.4×10^-4 rad.

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