本論文利用奈微米技術對於奈米光學生醫感測器進行一系列全面性理論模擬分析與實驗研究，針對不同型式的奈米粒子與陣列結構之表面電漿子誘導之光學增益特性，從單一奈米粒子到成對奈米粒子對、以至於特殊奈米結構陣列，作奈米粒子與奈米結構之尺寸、間距、形狀及入射光場激發偏振方向相關之光場分佈與強化特性探討。本研究利用近場光學掃描式顯微鏡直接觀察單一與成對奈米粒子所產生之區域電磁場強化及其近場分佈狀態，並利用三維有限時域差分法針對對稱及非對稱奈米結構陣列進行一系列特定極化電磁場強模擬計算，同時搭配螢光分子Rhodamine 6G (R6G) 做表面強化拉曼散射光譜量測，並計算出特定激發波段之陣列相對拉曼強化因子，以驗證模擬計算結果。文中也對於使用不同奈米粒子與陣列結構的製備方法及其生醫感測應用潛力做詳盡分析與討論。

This dissertation gives an overall study of the size-, interparticle distance-, shape-, and incident polarization-dependent optical field enhancements from a single nanoparticle and nanoparticle pairs to nanostructure arrays. The localized optical properties and electromagnetic (EM) field distributions of a nanoparticle and nanoparticle pairs are directly investigated by the near-field scanning optical microscope (NSOM). The field enhancements and relative enhancement factors of isotropic and anisotropic nanostructure arrays are individually studied via the three-dimensional (3D) finite-difference time-domain (FDTD) simulation and surface-enhanced Raman spectroscopy (SERS) with the probe of Rhodamine 6G (R6G) molecules. Different fabrication methods of nanoparticle substrates and nanostructure arrays are also presented in detail. Finally, the importance of size-, interparticle distance-, shape-, and incident polarization-dependent surface plasmon resonances associated with optical field enhancements and potential roles of periodic SERS-active substrates in biomedical sensing applications are summarized.

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