本研究之目的旨在探討一週的落地訓練之刺激對骨骼發展的影響。本研究中，實驗動物（大鼠）分為10次落地組（10L）、30次落地組(L30)及控制組（CON），其中落地組每日接受10次與30次自40公分的高處落下之訓練，共五天，於第一次訓練與第五次訓練架設測力板以取得地面反作用力作為運動強度探討。實驗動物訓練一週後犧牲，並採集其骨骼組織樣本進行動態與靜態骨骼組織型態學分析、骨骼組織生物力學壓斷測試分析。結果顯示：地面反作用力方面，大鼠在第一天落地時的地面反作用力與第五天者達顯著差異(p＜0.05)。動態組織型態學分析方面，訓練一週後，L10組於尺骨骨外膜的MAR與BFR/BS顯著高於控制組，L30組則是在骨外膜的BFR/BS和骨內膜的MAR顯著高於控制組。在骨骼組織生物力學壓斷測試分析方面，運動組的股骨各項指標皆小於控制，其中最大應力所能吸收的能量達顯著差異（p< 0.05），其餘各項分析與尺骨方面皆未達顯著差異，這有可能導因於受刺激之骨骼仍處於再塑作用階段，因而使得骨骼生物力學特性較差或無優於控制組的原因。結論：一週的落地訓練對成長中之大鼠骨骼而言，會增加尺骨部位的骨生成作用，另外，本研究未發現受刺激部位骨骼的織網骨生成，這顯示落地模型較貼接近人體運動模式，且可供未來從事局部性的機械性負荷對於骨代謝影響之研究。

The purpose of this study is to investigate the effects of free fall landing on local bone metabolism in growing female rats. In the present study, animals were randomly assigned into three groups, which were L30 group (n=11), L10 group (n=11) and control (CON) group (n=10). Animals of the L30 and L10 groups were subjected to 40cm high free fall landing for thirty times and ten times per day, respectively. Additionally, we acquired ground reaction force data form force plate on day 1 and day 5. Animals were sacrificed after a 5-day landing training. We used methods of dynamic histomorphometry, static histomorphometry and tissue biomechanical tests to estimate the effects of free fall landing on bone. In ground reaction force (GRF) measurement, peak GRF of day 5 were significantly lower than day 1 (p＜0.05). In static bone histomorphometry, all parameters showed no significantly difference among groups. In dynamic histomorphometry, total mineral apposition rate (MAR) and bone formation rate (BFR/BS, %) of periosteal of ulna were significantly higher in the L10 and L30 groups as compared to the CON group (p＜0.05). In addition, MAR of endosteal of ulna was also significantly higher in landing groups. In the biomechanical test of femur, max stress energy absorption was significantly lower in two landing groups, suggesting short-term landing training may induced a bone remodeling, which cause a transient weaker bone material. In conclusion, a 5-day landing training would produce a bone formation to ulna of rats without showing any woven bone as revealed by other animal mechanical loading model, suggesting the landing model would be more appropriate as a model for investigating the effects of local mechanical load on local bone metabolism.

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