骨質疏鬆症為老年人常見疾病之ㄧ，目前要暸解是否患有骨質疏鬆症，只能至醫院經由昂貴的量測儀器，如雙能量X射線吸收測量(DEXA)和超音波骨密度儀等設備來量測，才能確知骨質疏鬆程度，可謂耗時且不便，因此本研究的目的是發展一套攜帶方便、低價格和操作容易的超音波骨密度儀，其主要是量測波衰減(BUA)和波速(SOS)兩種參數，依此診斷骨質疏鬆程度。
　　本研究的設計，分為硬體和軟體兩方面，硬體方面主要有四個部份，分別為(1) 超音波發射器(Pulser) 以MOSFET為主要的發射開關，藉此產生脈波至探頭；(2) 超音波接收器(Receiver)利用TL071的低雜訊、低失真的運算放大器(Operational Amplifier)和AD811的高增益頻寬的運算放大器，來接收超音波訊號並作放大處理；(3) 控制器(Controller)使用單晶片(8051)來控制其他硬體動作並與電腦之間作資料傳輸；(4) 資料擷取(DAQ)部分將超音波訊號轉換成數位資料，並儲存在記憶體。軟體方面分為兩個部份，第一個部份為撰寫Controller(8051)所使用的組合語言程式來控制硬體動作；第二個部份為使用VB(Visual Basic)撰寫具有SOS和BUA功能的操作介面。
　　本研究結果，首先是已完成電壓300V的超音波Pulser/Receiver系統；在DAQ部分擷取速度最高15M Hz。在SOS參數方面，利用本系統對假體和腳跟骨所作的測試，誤差結果的都在2.1%以內。在BUA參數方面，利用本系統對假體量測，可區別正常骨和疏鬆骨假體；對腳跟骨的量測則無法確定，是否能有效判別骨質疏鬆。

　　Since osteoporosis is common disease for old people, it can only examine by expensive instrument in hospital, such as dual-energy X-ray absorptiometry (DEXA) and ultrasound densitometry system in hospital for evaluating the degree of osteoporosis. The purpose of this research is implementation of a portable ultrasound densitometry system. Two kinds of BUA parameter and SOS parameter by ultrasound measurement diagnose the osteoporosis degree.
　　The design of this research is divided into hardware and software. The hardware has four parts: (1) Pulser: using MOSFET as switch to generate the pulse. (2) Receiver: using the low noise, low distortion operational amplifier (TL071), and the high performance video operational amplifier (AD811) to receive ultrasound signal. (3) Controller: single chip (8051) control the hardware; (4) DAQ: acquire ultrasound signal and store data in RAM. The software has two parts: (1) writing the assemble language on Controller (8051) for controlling the hardware; (2) operation interface for with SOS and BUA function using for Visual Basic.
　　In this result, we have finished the system of ultrasonic Pulser/Receiver (300V) which can be sampled at 15MHz in DAQ part. In SOS measurement, errors are all less than 2.1% when utilize this system to test phantom and calcaneum. In BUA measurement, we can distinguish normal bone phantom and osteoporosis bone phantom; but the examination for calcaneum is not confirmed whether our system can differentiate the osteoporosis effectively.

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