此論文針對一系列新穎雙親性嵌段共聚高分子poly(triethylene glycol methacrylate)-b-poly(o-nitrobenzyl methacrylate) (PTEGMA-b-PNBMA, P0)與Poly(triethylene glycol methacrylate)-b-Poly[2-nitrobenzyl methacrylate-co-2- (1,2,3,4,5-pentaphenyl-1H-silol-1-yloxy)ethyl methacrylate] (PTEGMA-b- P[NBMA-co-AIE], P1,P2)所自組裝形成的高分子微胞之奈米結構與光物理性質進行探討。將具有Aggregation-Induced Emission (AIE)性質之螢光單體引入P1及P2之疏水鏈段，則其自組裝形成微胞具螢光性質，可運用在追蹤微胞位置做為細胞標記之應用。P0, P1, P2之疏水鏈段為具光敏性高分子PNBMA，其照光會裂解並由疏水性轉為親水性。P0, P1, P2之親水段為具溫感性質之高分子PTEGMA，當其溫度低於最低臨界溶解溫度(lower critical solution temperature, LCST)時，PTEGMA為親水性；當溫度高於LCST時，PTEGMA則由親水性轉為疏水性。利用此環境應答的特性造成高分子奈米載體之崩解，以達到控制藥物釋放的目的。

PPS-HEMA螢光基團在微胞核心狀態時之螢光強度較溶於有機溶劑中強，證明PPS-HEMA具有AIE的性質，利用此特性可測量P1及P2之臨界微胞濃度(Critical Micelle Concentration, CMC)分別為3.9 nM與 2.2nM。測量高分子微胞水溶液在不同溫度下之穿透度來求得LCST為41 ~ 42℃；藉由DLS測量高分子微胞粒徑約42.59 ~ 50.22 nm。含PPS-HEMA螢光基團之高分子P2運用於包覆藥物Doxorubincin(Dox)上，由於PPS-HEMA之螢光放射波長與Dox之吸收光譜重疊，當兩者距離小於10 nm時會產生Förster Resonance Energy Transfer (FRET)，可利用此效應確認Dox是否成功包覆於高分子微胞之核心。利用不同環境響應條件進行藥物釋放，實驗結果顯示，藥物載體經照光及提高溫度皆可促進P2/Dox微胞之Dox釋放。

In this study, we successfully synthesize a series of amphiphilic block copolymers PTEGMA-b-P(NBMA-co-AIE), containing thermo- and photo-responsive moieties and fluorophores with aggregation induced emission. These amphiphilic block copolymers could self-assemble in aqueous solution to form micelles due to their amphiphilic characteristic. The hydrophobic segments form the core and the hydrophilic segments form the corona of the micelles. Herein, the polymeric micelles are utilized as nanocarriers for the chemotherapy drug, doxorubicin (Dox), encapsulated by the oil-in-water emulsion procedure. The successful encapsulation and subsequent release of drug could be monitored by the occurrence and absence of Förster Resonance Energy Transfer (FRET) from micelles to drug. The controlled drug release is triggered either by UV irradiation or higher temperature.

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