硫化銅具有良好的生物相容性與光熱轉換效率，近年來陸續發表了許多硫化銅結合診斷與治療的相關文獻。卻鮮少有結合硫化銅奈米粒子與超音波影像的研究。超音波具有及時偵測、非侵入性、風險低且治療過程不會使病人感到不舒服等優點，且已被廣泛地使用於臨床診斷。大部分的超音波顯影劑可藉由裝載易揮發性的液體或者是氣體微泡的方式增強超音波影像，但親水性的中空硫化銅奈米粒子不適合裝載此類疏水性的液體或氣體。故本篇研究中，我們以金屬-配位子的配位方式，使親水性的中空硫化銅奈米粒子具有氣體產生的能力，進而產生超音波影像。首先，先合成實心的氧化亞銅奈米粒子，藉由非典型的克肯達效應 (modified-Kirkendall effect)，使實心結構的氧化亞銅經硫化後，產生中空的硫化銅奈米粒子。接著再以三價鐵離子做為金屬配位中心，將3,4-二羥基苯甲醛 (3, 4-dihydroxybenzaldehyde) 與碳酸氫根 (bicarbonate) 分別以雙配位和單配位的方式與三價鐵離子配位在一起。此配位的硫化銅奈米粒子經由近紅外光照射所產生的高溫可使碳酸氫根分解成二氧化碳，使得材料除了有效的光熱治療，可抑制腫瘤成長與腫瘤的消除，也具有超音波顯影的特性。

In this study, we provide a strategy of the metal ion-ligand coordination feature for the hydrophilic hollow nanostructures showing the capability of gas release to fulfill the echogenicity for the ultrasound imaging. We began with solid Cu2O nanoparticles, followed by a modified Kirkendall process to convert solid Cu2O into hollow porous CuS. The ferric ion (Fe3+) was used as the coordination center to bridge both dopamine and bicarbonate. The dopamine served as the bidentate ligand to coordinate Fe3+, while the bicarbonate coordinated to Fe3+ in a monodentate manner. The coordinated CuS nanoparticles revealing NIR light-induced hyperthermia resulted in the decomposition of bicarbonate into CO2 serving as echogenic source and the performance in inhibition of the tumor growth.

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