本篇研究為二氧化矽/氧化鐵/金奈米管之合成與其生物醫學之應用以及製備Gd2O(CO3)2‧H2O/二氧化矽/金複合粒子。
二氧化矽/氧化鐵/金奈米管以水溶性硫酸鈉奈米線作為模板，利用溶膠-凝膠法包覆上二氧化矽，以水移去模板，得二氧化矽奈米管，接著加入氧化鐵，繼而將表面修飾上氨基，利用靜電吸引力及共價鍵結與做為晶種之金奈米粒子結合，最後加入金鹽成長液，並以甲醛作還原劑，形成於近紅外光區具有吸收之金殼層。其中氧化鐵可做為MRI顯影劑，其測得之r2值為34.30 s-1mM-1，並以WST-1方法測試二氧化矽/氧化鐵/金奈米管對人類肺癌細胞（A549）之毒性，證實其具有相當良好之生物相容性，將抗體（anti-EGFR）修飾於二氧化矽/氧化鐵/金奈米管表面，將其分別和過度表現EGFR抗原之A549與無過度表現EGFR抗原之CL1-0兩株細胞做光熱治療，由於抗原抗體之專一辨識性，過度表現EGFR之A549將具有較良好之治療效果。
Gd2O(CO3)2‧H2O/二氧化矽/金複合粒子以本實驗室所發展之釓顯影劑Gd2O(CO3)2‧H2O粒子做為核，以溶膠-凝膠法包覆上二氧化矽，並以3-丙胺三乙氧基矽烷使得氨基為主要之官能基，並與金晶種結合，最後加入金鹽成長液，並以甲醛作為還原劑，將形成完整而緊密的金殼層，可藉由調控金殼層厚度改變其吸收光譜位置。

In this study, we fabricated silica/iron oxide/gold nanotubes and Gd2O(CO3)2.H2O/silica/gold hybrid particles as bifunctional materials for simultaneous MR imaging and photothermal therapy.
Silica/iron oxide/gold nanotubes have been prepared by firstly using water-soluble Na2SO4 nanowires as a soft template to obtain silica nanotubes, then incorporating iron oxide nanoparticles and Au seeds with the surface of silica nanotubes, and finally growing of gold shell. As can be observed in UV-vis spectra, these materials can absorb the near infrared (NIR) radiation due to the existence of gold shells. Because of combining superparamagnetic iron oxide nanoparticles, the materials were served as MRI contrast agents. The results showed the value of relaxivity r2 is 34.30 s-1mM-1. The cytotoxicity of the Silica/iron oxide/gold nanotubes were also examined with A549 lung cancer cells which overexpress EGFR by using WST-1 assay, and the results showed their good biocompatibility. The performance on photothermal cancer destroying has been demonstrated on A549 cells with a NIR laser after targeting anti-EGFR antibody-conjugated Silica/iron oxide/gold nanotubes. The selectivity targeting leads to different photothermal destruction between A549 and CL1-0 cells, while A549 can be readily destructed by photothermal method compared to CL1-0 with less EGFR expression.
Another multifunctional Gd2O(CO3)2.H2O/silica/gold hybrid particles with a core/shell structure have been designed and synthesized. Silica shells could be synthesized by hydrolysis and condensation of tetraethoxysilan (TEOS) on the surface of Gd2O(CO3)2.H2O nanoparticles. The amino functional groups on the surface of Gd2O(CO3)2.H2O/silica were functionalized with 3-aminopropyl-triethoxysilane(APS). For further shell-growth on the gold seeds, gold seeds were previously decorated on the silica layer in gold growth solution, and formaldehyde was added into solution to reduce gold ions on the seeds. The thickness of Au shell on the Gd2O(CO3)2.H2O/silica particles can be systematically tuned by tailoring the amount of HAuCl4 in growth solution. We found the significant variations in UV-vis spectra and the absorbance peaks were depended on the thickness of Au shells.

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