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研究生： 楊翔甯
Yang, Shiang-Ning
論文名稱： 雙邊不對稱球體的異質自組裝行為與螢光能量共振轉移
Fӧrster Resonance Energy Transfer in the Heterogeneous Assembly of Janus particles
指導教授： 郭昌恕
Kuo, Chang-Shu
學位類別： 碩士
Master
系所名稱： 工學院 - 材料科學及工程學系
Department of Materials Science and Engineering
論文出版年： 2017
畢業學年度： 105
語文別： 中文
論文頁數： 91
中文關鍵詞： 雙邊不對稱球體 、共同自組裝 、螢光共振能量轉移
外文關鍵詞： Janus particles, FRET, co-assembly
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    • 在本研究中，合成次微米雙邊不對稱球體並與100nm聚苯乙烯顆粒利用表面靜電力行共同自組裝。理想的共同自組裝是由四顆500nm雙邊不對稱球體排列成四面體，四面體的中心為聚苯乙烯顆粒組成。而共同自組裝的結構是由雙邊不對稱球體及聚苯乙烯顆粒間的顆粒比和顆粒大小所控制，此系統下的共同自組裝可形成多種不同的結構``。
    雙邊不對稱球體是進行共同自組裝的主要顆粒，雙邊不對稱球體是由500nm的氧化矽顆粒作為核心，且其中三分之一表面帶有胺基並接上AB或NBDHA。另一種參與共同自組裝且較小的顆粒是由廠商提供的100nm聚苯乙烯顆粒，其表面帶有醋酸根的官能基。AB和NBDHA 分別代表螢光共振能量轉移的供體與受體。由於螢光能量共振轉移的特性，需要供體分子與受體分子之間非常靠近才能觸發螢光共振能量轉移，利用此特性可以去觀察共同共組裝的現象與形成。利用動態光散射光譜儀去觀察粒徑的增加以及螢光共振能量轉移所產生的螢光訊號可以明確的證明雙邊不對稱球體與聚苯乙烯顆粒的共同自組裝行為。藉由共軛聚焦顯微鏡觀察共組裝的團簇及其放出的螢光，確保供體與受體的雙邊不對稱體均有參與共組裝行為而觸發螢光共振能量轉移。穩定的共同自組裝和螢光共振能量轉移的訊號可以做為感測器機器與平台。

    Asymmetric submicron Janus particles were fabricated and co-assembled with 100 nm polystyrene (PS) particles by surface electrostatic force interaction. The ideal co-assembled structure was a tetramer where four 500 nm Janus particles assembled as tetrahedron arrangement with one 100 nm PS particle in the center. The co-assembled structure with different morphologies were mainly determined by the sizes and the ratios of two particles. The co-assembled structure also included the different morphologies.
    The particle co-assembly was carried out by Janus particles cored with 500 nm silica particles and functionalized with amino-silane in one of their hemispheric surfaces, followed by their conjugation with Atlantic Blue dye or NBDHA. And, the second particles with smaller diameters in the co-assembly were commercially-available PS particles, which were 100 nm polystyrene (PS) particles with carboxylated surface. Two fluorescent dyes, Atlantic Blue and NBDHA, were employed as the FRET donor and acceptor, respectively. Since the FRET took place only when the distance between the donor and acceptor objects was very close, the successful FRET signals indicated the cluster formation from the particle co-assembly. Well-defined particle co-assembly simultaneously initiated the cluster diameter increase as shown in the DLS measurement, as well as the FRET emission from their photoluminescence outputs. Observed the fluorescence color of combination type of co-assembled clusters by confocal microscope to make sure the co-assembled clusters at least included one donor and one acceptor JPs to trigger the FRET effect. Steady particle co-assembly and the related FRET responses realized the sensor mechanism and platform.

    中文摘要 I Abstract II 致謝 III Table of Contents IV List of Illustrations VI List of Table VIII Chapter1 Introduction 1 1.1. Janus particles 1 1.1.1. Different type of Janus particles 2 1.1.2. Summary of fabrications Janus particles 2 1.1.3. Janus Characterizations 15 1.2. Particles assembly behavior 19 1.2.1. Introduction to self-assembly 19 1.2.2. Field-induced self-assembly 24 1.2.3. Application of self-assembly 25 1.3. Förster resonance energy transfer 28 1.3.1. Mechanism 29 1.3.2. Applications 32 Chapter2 Research Motivations 34 Chapter3 Experimental 35 3.1. Chemicals 35 3.2. Instruments used in material fabrication 38 3.3. Experiment process 39 3.3.1. Electrospinning of P4VP/PMMA blend fiber 39 3.3.2. Preparation of 500 nm magnetic silica nanoparticles 40 3.3.3. Dipping process of silica colloid adsorption 40 3.3.4. Thermal-induced embedding 40 3.3.5. CVD process of amino-modified 41 3.3.6. Dissolve P4VP/PMMA fiber 41 3.3.7. Dye-functionalized 41 3.4. Analytical instruments 43 3.4.1. Particle size distribution (dynamic light scattering) 43 3.4.2. Zeta potential 43 3.4.3. Dark field optical microscopy 44 3.4.4. UV-vis spectrometer (UV-vis) 45 3.4.5. Photoluminescence spectroscopy (PL) 45 3.4.6. Photoluminescence optical system 45 3.4.7. Scanning electron microscopy (SEM) 46 Chapter4 Results and Discussion 47 4.1. Dye characterization 47 4.1.1. The spectra and calibration curve of the NBDHA dye 47 4.1.2. AB, NBDHA and their FRET 50 4.1.3. The FRET effect on dye solutions 52 4.2. Fabrication of dye-functionalized Janus 61 4.2.1. Fabrication of NBDHA-modified Janus particles 61 4.2.2. Fabrication of NBDHA-modified Janus particles 62 4.2.3. Fabrication of AB-modified Janus particles 63 4.2.4. Quantify remain amino group of fabrication of NBDHA-modified Janus 63 4.2.5. Zeta potential analysis 64 4.3. The co-assembly behavior of Janus particles and 100nm PS particles 68 4.3.1. Electrostatic interaction and reversible dynamic co-assembly 68 4.4. The FRET effect of heterogeneous assembly 74 Chapter5 Conclusion 83 Chapter6 Reference 85

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