本研究欲設計合成一雙親水性嵌段高分子(double-hydrophilic block copolymer)聚(乙烯醇-乙醯胺)(Poly(VA-b-VAm))。首先利用鈷觸媒活性自由基聚合(Cobalt-Mediated radical Polymerization, CMRP)法，在氧化起始系統(BPO/Na3CA)下以乙醯丙酮鈷(Cobalt(II) acetylacetonate, Co(acac)2)作為觸媒控制聚合乙酸乙烯酯(VAc)，再將合成之PVAc高分子鏈末端乙醯丙酮鈷置換成鏈轉移劑(CTA)以得到PVAc macroCTA，最後以可逆加成-斷裂鏈轉移聚合(Reversible Addition-Fragmentation Chain Transfer, RAFT)將PVAc macroCTA與乙烯丙醯胺(NVF)單體反應得到聚(乙酸乙烯酯-乙烯丙醯胺)嵌段共聚物(Poly(VAc-b-NVF)。將聚(乙酸乙烯酯-乙烯丙醯胺)嵌段共聚物在鹼性條件下水解即可得到聚(乙烯醇-乙醯胺)嵌段共聚物(Poly(VA-b-VAm))。另外，本研究以聚乙烯胺與水楊醛(Salicylaldehyde)及吡咯-2-甲醛(Pyrrole-2-caroboxaldehyde)反應合成聚乙烯胺希夫鹼(Schiff base)，以甲醇/水共溶劑或純水為反應溶劑，並調整不同進料莫爾比例得到不同希夫鹼百分比之聚乙烯胺希夫鹼。

First, Poly(vinyl acetate)-block-Poly(vinyl formamide) (PVAc-b-PNVF) block copolymers were successfully synthesis by a combination of cobalt-mediated radical polymerization (CMRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. PVAc were first synthesized via CMRP with cobalt(Ⅱ) acetylacetonate in redox system. The cobalt complexes attached to chain end were modified into a xanthate group chain transfer agent by reacting with dimethyl sulfoxide at 50℃,producing PVAc macro chain transfer agents (PVAc macroCTA). The RAFT polymerization of vinylformamide (NVF) with PVAc macroCTA was conducted in dimethyl sulfoxide at 90℃ to obtain PVAc-b-PNVF block copolymers. The PVAc-b-PNVF copolymer was hydrolyzed to double hydrophilic Poly(vinyl alcohol)-block-Poly(vinyl amine) (PVA-b-PVAm) copolymer under basic condition.Well-defined PVA-b-PVAm block copolymer were confirmed by aqueous GPC and 1H NMR.
Second, Schiff base of polyvinyl amine were synthesized by the reaction with salicylaldehyde and pyrrole-2-carboxaldehyde. Different mol% polymeric Schiff base can be controlled by different inlet ratio. And eco-friendly reaction or called “green synthesis” of Schiff base also be synthesized by stirring PVAm with different aldehydes in water as solvent. The product is purified by centrifugation and filtration followed by washing with water and dried in vacuum.

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